scholarly journals LOW DOSE (4.5 MG/KG) OF THYMOGLOBULIN IS EFFECTIVE TO CONTROL T CELLS BUT NOT B CELLS AND CD56DIMCD57+, CD56DIMNKG2A+ NATURAL KILLER CELLS RESULTING IN DE NOVO DONOR-SPECIFIC ANTIBODY FORMATION AND ACUTE REJECTION IN NON-SENSITIZED LIVING DONOR KIDNEY RECIPIENTS WITH EARLY STEROID WITHDRAWAL

2020 ◽  
Vol 104 (S3) ◽  
pp. S616-S616
Author(s):  
Youngmin Ko ◽  
Hey Rim Jung ◽  
Mi Joung Kim ◽  
Yu-Mee Wee ◽  
Monica Young Choi ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Rejection ◽  
Antibody Formation ◽  
Living Donor ◽  
Low Dose ◽  
De Novo ◽  
Steroid Withdrawal ◽  
Donor Kidney ◽  
Kidney Recipients ◽  
Living Donor Kidney

scholarly journals Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hye Ryoun Jang ◽  
Minjung Kim ◽  
Sungjun Hong ◽  
Kyungho Lee ◽  
Mee Yeon Park ◽  
...  
Keyword(s):  
T Cells ◽  
Cohort Study ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Prospective Cohort ◽  
Living Donor ◽  
Validation Cohort ◽  
Donor Kidney ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

AbstractWe investigated the clinical relevance of urinary cytokines/chemokines reflecting intrarenal immunologic micromilieu as prognostic markers and the optimal measurement timing after living donor kidney transplantation (LDKT). This prospective cohort study included 77 LDKT patients who were followed for ≥ 5 years. Patients were divided into control (n = 42) or acute rejection (AR, n = 35) group. Early AR was defined as AR occurring within 3 months. Serum and urine cytokines/chemokines were measured serially as follows: intraoperative, 8/24/72 h, 1 week, 3 months, and 1 year after LDKT. Intrarenal total leukocytes, T cells, and B cells were analyzed with immunohistochemistry followed by tissueFAXS. Urinary MCP-1 and fractalkine were also analyzed in a validation cohort. Urinary MCP-1 after one week was higher in the AR group. Urinary MCP-1, fractalkine, TNF-α, RANTES, and IL-6 after one week were significantly higher in the early AR group. Intrarenal total leukocytes and T cells were elevated in the AR group compared with the control group. Urinary fractalkine, MCP-1, and IL-10 showed positive correlation with intrarenal leukocyte infiltration. Post-KT 1 week urinary MCP-1 showed predictive value in the validation cohort. One-week post-KT urinary MCP-1 may be used as a noninvasive diagnostic marker for predicting AR after LDKT.

COMPARISON OF OUTCOME WITH LOW-DOSE ANTI- THYMOCYTE GLOBULIN, BASILIXIMAB OR NO ANTIBODY INDUCTION THERAPY IN ADULT LIVING DONOR KIDNEY RECIPIENTS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 644
Author(s):  
P W. Baron ◽  
J Weissman ◽  
R Ben-Youssef ◽  
E Franco ◽  
A Kore ◽  
...  
Keyword(s):  
Induction Therapy ◽  
Living Donor ◽  
Low Dose ◽  
Donor Kidney ◽  
Kidney Recipients ◽  
Antibody Induction ◽  
Living Donor Kidney

scholarly journals Outcome Comparison between Low-Dose Rabbit Anti-Thymocyte Globulin and Basiliximab in Low-Risk Living Donor Kidney Transplantation

2020 ◽  
Vol 9 (5) ◽  
pp. 1320
Author(s):  
Sang Jin Kim ◽  
Jinsoo Rhu ◽  
Heejin Yoo ◽  
Kyunga Kim ◽  
Kyo Won Lee ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Failure ◽  
Living Donor ◽  
Low Dose ◽  
De Novo ◽  
Donor Kidney ◽  
Living Donor Kidney Transplantation ◽  
Donor Kidney Transplantation ◽  
Cmv Antigenemia ◽  
Living Donor Kidney

The objective of this study was to compare outcomes between basiliximab and low-dose r-ATG in living donor kidney transplantation recipients with low immunological risk. Patients in the low-dose r-ATG group received 1.5 mg/kg of r-ATG for 3 days (total 4.5 mg/kg). Graft survival, patient survival, acute rejection, de novo donor specific antibody (DSA), estimated glomerular filtration rate (e-GFR) changes, and infection status were compared. Among 268 patients, 37 received r-ATG, and 231 received basiliximab. There was no noticeable difference in the graft failure rate (r-ATG vs. basiliximab: 2.7% vs. 4.8%) or rejection (51.4% vs. 45.9%). de novo DSA was more frequent in the r-ATG group (11.4% vs. 2.4%, p = 0.017). e-GFR changes did not differ noticeably between groups. Although most infections showed no noticeable differences between groups, more patients in the r-ATG group had cytomegalovirus (CMV) antigenemia and serum polyomavirus (BK virus) (73.0% vs. 51.9%, p = 0.032 in CMV; 37.8% vs. 15.6%, p = 0.002 in BK), which did not aggravate graft failure. Living donor kidney transplantation patients who received low-dose r-ATG and patients who received basiliximab showed comparable outcomes in terms of graft survival, function, and overall infections. Although CMV antigenemia, BK viremia were more frequent in the r-ATG group, those factors didn’t change the graft outcomes.

Optimal blood levels of (extended-release) tacrolimus in living donor kidney transplantation to prevent de novo donor-specific antibody production: A retrospective cohort study

2021 ◽  
Vol 91 ◽  
pp. 107038
Author(s):  
Takahisa Hiramitsu ◽  
Toshihide Tomosugi ◽  
Kenta Futamura ◽  
Manabu Okada ◽  
Morikuni Nishihira ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort ◽  
Living Donor ◽  
Extended Release ◽  
De Novo ◽  
Blood Levels ◽  
Donor Kidney ◽  
Specific Antibody Production ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

FoxP3 Positive T Cells in Graft Biopsies From Living Donor Kidney Transplants After Donor-Specific Transfusions

2009 ◽  
Vol 87 (1) ◽  
pp. 138-142 ◽  
Author(s):  
Ute Eisenberger ◽  
Andrea Seifried ◽  
Natacha Patey ◽  
Andreas Kappeler ◽  
Laure-Hélène Noel ◽  
...  
Keyword(s):  
T Cells ◽  
Living Donor ◽  
Kidney Transplants ◽  
Donor Kidney ◽  
Living Donor Kidney

Pre-transplant immune state defined by serum markers and alloreactivity predicts acute rejection after living donor kidney transplantation

2014 ◽  
Vol 28 (9) ◽  
pp. 968-979 ◽  
Author(s):  
Florian W.R. Vondran ◽  
Kai Timrott ◽  
Sonja Kollrich ◽  
Ann-Kristin Steinhoff ◽  
Alexander Kaltenborn ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Acute Rejection ◽  
Living Donor ◽  
Serum Markers ◽  
Donor Kidney ◽  
Living Donor Kidney Transplantation ◽  
Immune State ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

A Transient Increase of Calcineurin Phosphatase Activity in Living-Donor Kidney Transplant Recipients with Acute Rejection

2010 ◽  
Vol 25 (5) ◽  
pp. 411-417 ◽  
Author(s):  
Masahide Fukudo ◽  
Ikuko Yano ◽  
Toshiya Katsura ◽  
Noriyuki Ito ◽  
Shingo Yamamoto ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Phosphatase Activity ◽  
Kidney Transplant ◽  
Living Donor ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Donor Kidney ◽  
Calcineurin Phosphatase ◽  
Living Donor Kidney Transplant ◽  
Living Donor Kidney

Late Steroid Withdrawal After ABO Blood Group-Incompatible Living Donor Kidney Transplantation: High Rate of Mild Cellular Rejection

2010 ◽  
Vol 89 (6) ◽  
pp. 702-706 ◽  
Author(s):  
Tobias Oettl ◽  
Eugenia Zuliani ◽  
Ariana Gaspert ◽  
Helmut Hopfer ◽  
Michael Dickenmann ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Blood Group ◽  
Living Donor ◽  
High Rate ◽  
Abo Blood Group ◽  
Steroid Withdrawal ◽  
Donor Kidney ◽  
Donor Kidney Transplantation ◽  
Cellular Rejection ◽  
Living Donor Kidney
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