Successful Surgical Treatment of Severe Burn in an Immunocompromised Patient Under Long-Term Treatment for Frequently Relapsing Nephrotic Syndrome

Diffuse toxic goiter (DTG) is an autoimmune disease, to which there is a genetic predisposition. In children DTG is less common than in adults. Manifestation of graves‘ disease in childhood has a number of peculiarities. During the DTG in children is usually manifested thyrotoxicosis, requiring long-term treatment to achieve euthyroid, tendency to relapse and more frequently than adults, accompanied by ophthalmopathy and the large size of goiter. Diagnosis of graves‘ disease is based on the clinical picture of thyrotoxicosis, the existence of which is confirmed by the level of thyroid hormones and TSH in the blood. There are three types of treatment of patients DTG: medical, radioactive iodine therapy and surgery. There is no а single glance at the choice of the volume of operations in children.

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Oral bisacodyl is effective and safe for short term treatment of chronic constipation

Clinical Research in Practice The Journal of Team Hippocrates ◽

10.22237/crp/1622160780 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Akanksha Vaishnav

Keyword(s):

Surgical Treatment ◽

Chronic Constipation ◽

Clinical Decision ◽

Term Treatment ◽

Short Term ◽

Short Term Treatment ◽

Long Term Treatment ◽

History Of ◽

Non Surgical Treatment

A clinical decision report using: Kamm MA, Mueller-Lissner S, Wald A, Richter E, Swallow R, Gessner U. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol. 2011;9(7):577-583. https://doi.org/10.1016/j.cgh.2011.03.026 to evaluate potential long term treatment with oral Bisacodyl in a patient with a history of chronic constipation and recent non-surgical treatment of ischemic colitis.

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Potentialities and Principles of Low-Invasive Osteosynthesis at Bones Fractures Treatment

N.N. Priorov Journal of Traumatology and Orthopedics ◽

10.17816/vto20111825-11 ◽

2011 ◽

Vol 18 (2) ◽

pp. 5-11

Author(s):

A F Lazarev ◽

Eduard Ivanovich Solod ◽

A A Lazarev ◽

A F Lazarev ◽

E I Solod ◽

...

Keyword(s):

Comparative Analysis ◽

Surgical Treatment ◽

Treatment Outcomes ◽

Bone Fractures ◽

Term Treatment ◽

Long Term Treatment ◽

Osteosynthesis Techniques ◽

Percutaneous Osteosynthesis

Experience in surgical treatment of 519 patients with bone fractures of different localization been treated during 2000 - 2009 was analyzed. In 335 patients low-invasive percutaneous osteosynthesis with application of original and known low-invasive technologies was performed. In 184 patients with similar fractures osteosynthesis by standard conventional techniques was performed during the period from 2000 to 2004. Comparative analysis of early and long-term treatment outcomes showed the advantage of low-invasive osteosynthesis techniques at treatment of fractures with different localization. Main principles and peculiarities of low-invasive osteosynthesis were determined.

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Successful Long-Term Treatment of Cerebral Nocardiosis with Unexpectedly Low Doses of Linezolid in an Immunocompromised Patient Receiving Complex Polytherapy

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00135-12 ◽

2012 ◽

Vol 56 (6) ◽

pp. 3438-3440 ◽

Cited By ~ 14

Author(s):

Federico Pea ◽

Piergiorgio Cojutti ◽

Alberto Pagotto ◽

Francesco Cristini ◽

Mario Furlanut ◽

...

Keyword(s):

Mortality Rate ◽

Therapeutic Drug Monitoring ◽

Immunocompromised Patient ◽

Severe Infection ◽

Term Treatment ◽

Therapeutic Drug ◽

Low Doses ◽

Long Term Treatment ◽

Cerebral Nocardiosis

ABSTRACTCerebral nocardiosis is a severe infection that carries the highest mortality rate among all bacterial cerebral abscesses. We report on a case in an immunocompromised patient which was successfully treated with unexpectedly low doses of linezolid. Therapeutic drug monitoring was very helpful in highlighting issues of poor compliance and of drug-drug interactions.

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Surgical treatment of urinary stress incontinence nowadays

Medicina ◽

10.3390/medicina43080086 ◽

2006 ◽

Vol 43 (8) ◽

pp. 671

Author(s):

Sonata Barilienė ◽

Rosita Aniulienė

Keyword(s):

Surgical Treatment ◽

Stress Incontinence ◽

American Association ◽

Urinary Stress Incontinence ◽

Term Treatment ◽

Suburethral Sling ◽

First Year ◽

Surgical Methods ◽

Long Term Treatment

There are various surgical methods for the treatment of female urinary stress incontinence. According to the opinion of American Association of Urologists, anterior colpoplasty is supposed to be the least effective for the long-term treatment out of four surgical treatment categories (anterior colpoplasty, suburethral sling, colposuspension, and long-needle sling). Nowadays, the open retropubic colposuspension (Burch operation) is considered the most effective and long-term treatment of the female urinary stress incontinence. A first-year postsurgical effectiveness is 85–90% for this operation. Tension-free vaginal tape (suburethral sling) operations are considered as much effective as the above-mentioned surgeries and tend to be very perspective. However, these operations require to be evaluated for their long-term systematic results.

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Rituximab in childhood steroid-sensitive nephrotic syndrome: are multiple subsequent courses safe and effective?

Archives of Disease in Childhood ◽

10.1136/archdischild-2020-319609 ◽

2020 ◽

pp. archdischild-2020-319609

Author(s):

Chantida Subun ◽

Picha Suwannahitatorn ◽

Hazel Webb ◽

Kjell Tullus

Keyword(s):

Nephrotic Syndrome ◽

Side Effects ◽

Age Groups ◽

Term Treatment ◽

Street Hospital ◽

Steroid Dependency ◽

Great Ormond Street Hospital ◽

Steroid Dependent ◽

Long Term Treatment

IntroductionIdiopathic nephrotic syndrome is the most common glomerular disease in children. The majority of patients respond well to steroids. However, the relapse rate is high and many develop steroid dependency. Although other immunosuppressive medicines are successfully used as steroid-sparing agents, some children still have frequent relapsing episodes. Rituximab (RTX), a chimeric anti-CD20 monoclonal antibody, has shown to be effective in treating difficult frequently relapsing/steroid-dependent nephrotic syndrome (FR/SDNS). Data on the effectiveness and long-term treatment outcomes of repeated courses of RTX are, however, scarce.Material and methodsChildren and young people with FR/SDNS, aged 1–18 years, who received RTX at Great Ormond Street Hospital (GOSH) from 2006 to 2018 were reviewed.ResultsDuring these 12 years, 103 children with FR/SDNS received RTX infusions at GOSH. Among these, 58 cases needed repeated courses of RTX: 2, 3, 4, 5, 6 and 7 repeated courses were given to 21, 21, 7, 5, 1 and 3 patients, respectively. The overall median time to relapse post-RTX was 11 months (range 1–53 months). There was no change in relapse-free interval with subsequent courses of RTX. No difference was found between age groups, genders and ethnicities. No severe side effects were noted.ConclusionsRTX seems to be safe even after several repeated courses. However, long-term follow-up and further studies are needed, with a focus on side-effects in particular.

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