Cost-Effectiveness Comparison Between Topical Silver Sulfadiazine and Enclosed Silver Dressing for Partial-Thickness Burn Treatment

Silver sulfadiazine is commonly used in the treatment of partial-thickness burns, but it sometimes forms pseudo-eschar and delays wound healing. Polyhexanide/betaine gel, a new wound cleansing and moisturizing product, has some advantages in removing biofilm and promotes wound healing. This study was designed to compare clinical efficacy of polyhexanide/betaine gel with silver sulfadiazine in partial-thickness burn treatment. From September 2013 to May 2015, 46 adult patients with partial-thickness burn ≥10% total body surface area that were admitted to the Burn Unit of Siriraj Hospital within 48 hours after injury were randomly allocated into 2 groups. One group was treated with polyhexanide/betaine gel, and the other group was treated with silver sulfadiazine. Both groups received daily dressing changes and the same standard care given to patients with burns in this center. Healing times in the polyhexanide/betaine gel group and silver sulfadiazine group were 17.8 ± 2.2 days and 18.8 ± 2.1 days, respectively ( P value .13). There were no significant differences in healing times, infection rates, bacterial colonization rates, and treatment cost in both groups. The pain score of the polyhexanide/betaine gel group was significantly less than the silver sulfadiazine group at 4 to 9 days after treatment ( P < .001). The satisfactory assessment result of the polyhexanide/betaine gel group was better than that in the silver sulfadiazine group. These data indicate the need for adequately designed studies to elicit the full potential of polyhexanide gel as a wound dressing for partial-thickness burn wounds.

Download Full-text

Cost-Effectiveness Comparison Between Biobrane and Suprathel for Partial Thickness Burn Treatment for Austria

Value in Health ◽

10.1016/j.jval.2017.08.2389 ◽

2017 ◽

Vol 20 (9) ◽

pp. A802 ◽

Cited By ~ 1

Author(s):

S Wahler ◽

P Wurzer ◽

L Kamolz ◽

A Müller

Keyword(s):

Cost Effectiveness ◽

Burn Treatment ◽

Partial Thickness ◽

Partial Thickness Burn

Download Full-text

Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study

Journal of Burn Care & Research ◽

10.1093/jbcr/irz149 ◽

2019 ◽

Cited By ~ 1

Author(s):

Edmar Maciel Lima Júnior ◽

Manoel Odorico de Moraes Filho ◽

Antonio Jorge Forte ◽

Bruno Almeida Costa ◽

Francisco Vagnaldo Fechine ◽

...

Keyword(s):

Pilot Study ◽

Test Group ◽

Silver Sulfadiazine ◽

Control Group ◽

Burn Wound ◽

Open Label ◽

Burn Treatment ◽

Partial Thickness ◽

Partial Thickness Burn ◽

Partial Thickness Burns

Abstract This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial “partial-thickness” burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.

Download Full-text

New Innovations for Deep Partial-Thickness Burn Treatment with ACell MatriStem Matrix

Advances in Wound Care ◽

10.1089/wound.2015.0681 ◽

2016 ◽

Vol 5 (12) ◽

pp. 546-552 ◽

Cited By ~ 16

Author(s):

Justine S. Kim ◽

Alexander J. Kaminsky ◽

J. Blair Summitt ◽

Wesley P. Thayer

Keyword(s):

Burn Treatment ◽

Partial Thickness ◽

Partial Thickness Burn

Download Full-text

The safety and efficacy of feracrylum as compared to silver sulfadiazine in the management of deep partial thickness burn: A clinical study report

Medical Journal of Indonesia ◽

10.13181/mji.v17i4.329 ◽

2008 ◽

pp. 259 ◽

Cited By ~ 4

Author(s):

Yefta Moenadjat ◽

Rianto Setiabudy ◽

Dalima A.W. Astrawinata ◽

Saukani Gumay

Keyword(s):

Clinical Study ◽

Silver Sulfadiazine ◽

Safety And Efficacy ◽

Clinical Study Report ◽

Study Report ◽

Partial Thickness ◽

Partial Thickness Burn

Download Full-text

A pirfenidone loaded spray dressing based on lyotropic liquid crystals for deep partial thickness burn treatment: healing promotion and scar prophylaxis

Journal of Materials Chemistry B ◽

10.1039/c9tb02929j ◽

2020 ◽

Vol 8 (13) ◽

pp. 2573-2588 ◽

Cited By ~ 1

Author(s):

Jintian Chen ◽

Hui Wang ◽

Liling Mei ◽

Bei Wang ◽

Ying Huang ◽

...

Keyword(s):

Wound Healing ◽

Liquid Crystal ◽

Liquid Crystals ◽

Lyotropic Liquid Crystals ◽

Lyotropic Liquid Crystal ◽

Burn Treatment ◽

Partial Thickness ◽

Partial Thickness Burn

This study develops a HA combined lyotropic liquid crystal based spray dressing loaded with pirfenidone for wound healing and scar prophylaxis.

Download Full-text

Hyaluronic acid covers in burn treatment: a systematic review

Revista da Escola de Enfermagem da USP ◽

10.1590/s0080-623420160000400020 ◽

2016 ◽

Vol 50 (3) ◽

pp. 522-528 ◽

Cited By ~ 1

Author(s):

Michel Marcos Dalmedico ◽

Marineli Joaquim Meier ◽

Jorge Vinícius Cestari Felix ◽

Franciele Soares Pott ◽

Francislene de Fátima Cordeiro Petz ◽

...

Keyword(s):

Systematic Review ◽

Hyaluronic Acid ◽

Randomized Controlled Trials ◽

Complete Healing ◽

Silver Sulfadiazine ◽

Controlled Trials ◽

Burn Treatment ◽

Randomized Controlled ◽

Partial Thickness ◽

Partial Thickness Burns

Abstract OBJECTIVE To evaluate the effectiveness of hyaluronic acid in the healing of partial thickness burns. METHOD Systematic review of randomized controlled trials on the use of hyaluronic acid for the topical treatment of skin burns, based on recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. RESULTS Two randomized controlled trials that analyzed 143 patients with partial thickness burns and/or deep partial thickness burns were selected. They compared the application of hyaluronic acid 0.2% associated to silver sulfadiazine 1% 5g/cm2 versus silver sulfadiazine 1% 5g/cm2 alone for the outcome of complete healing. CONCLUSION This review emphasizes the need for new well-designed randomized controlled trials to establish the therapeutic relevance of hyaluronic acid with respect to the healing of burns of partial thickness or deep partial thickness.

Download Full-text