New Innovations for Deep Partial-Thickness Burn Treatment with ACell MatriStem Matrix

Partial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified), collagen hydrogel, or silver sulfadiazine (SSD). Digital images of each wound were taken for area measurements immediately prior to cleaning and dressing changes. Wound tissue was collected and assessed histologically at several time points. Wound area showed a significant difference between hydrogels and SSD groups, and rates of reepithelialization at early time points showed an increase when keratin treatment was used compared to both collagen and SSD. A linear regression model predicted a time to wound closure of approximately 25 days for keratin hydrogel while SSD treatment required 35 days. There appeared to be no measurable differences between the modified and unmodified formulations of keratin hydrogels.

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Randomized Controlled Trial of Polyhexanide/Betaine Gel Versus Silver Sulfadiazine for Partial-Thickness Burn Treatment

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734617690949 ◽

2017 ◽

Vol 16 (1) ◽

pp. 45-50 ◽

Cited By ~ 6

Author(s):

Saruta Wattanaploy ◽

Kusuma Chinaroonchai ◽

Nantaporn Namviriyachote ◽

Pornprom Muangman

Keyword(s):

Wound Healing ◽

Bacterial Colonization ◽

Controlled Trial ◽

Total Body Surface Area ◽

Silver Sulfadiazine ◽

P Value ◽

Full Potential ◽

Burn Treatment ◽

Partial Thickness ◽

Partial Thickness Burn

Silver sulfadiazine is commonly used in the treatment of partial-thickness burns, but it sometimes forms pseudo-eschar and delays wound healing. Polyhexanide/betaine gel, a new wound cleansing and moisturizing product, has some advantages in removing biofilm and promotes wound healing. This study was designed to compare clinical efficacy of polyhexanide/betaine gel with silver sulfadiazine in partial-thickness burn treatment. From September 2013 to May 2015, 46 adult patients with partial-thickness burn ≥10% total body surface area that were admitted to the Burn Unit of Siriraj Hospital within 48 hours after injury were randomly allocated into 2 groups. One group was treated with polyhexanide/betaine gel, and the other group was treated with silver sulfadiazine. Both groups received daily dressing changes and the same standard care given to patients with burns in this center. Healing times in the polyhexanide/betaine gel group and silver sulfadiazine group were 17.8 ± 2.2 days and 18.8 ± 2.1 days, respectively ( P value .13). There were no significant differences in healing times, infection rates, bacterial colonization rates, and treatment cost in both groups. The pain score of the polyhexanide/betaine gel group was significantly less than the silver sulfadiazine group at 4 to 9 days after treatment ( P < .001). The satisfactory assessment result of the polyhexanide/betaine gel group was better than that in the silver sulfadiazine group. These data indicate the need for adequately designed studies to elicit the full potential of polyhexanide gel as a wound dressing for partial-thickness burn wounds.

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Cost-Effectiveness Comparison Between Biobrane and Suprathel for Partial Thickness Burn Treatment for Austria

Value in Health ◽

10.1016/j.jval.2017.08.2389 ◽

2017 ◽

Vol 20 (9) ◽

pp. A802 ◽

Cited By ~ 1

Author(s):

S Wahler ◽

P Wurzer ◽

L Kamolz ◽

A Müller

Keyword(s):

Cost Effectiveness ◽

Burn Treatment ◽

Partial Thickness ◽

Partial Thickness Burn

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Use of Tilapia Skin as a Xenograft for Pediatric Burn Treatment: A Case Report

Journal of Burn Care & Research ◽

10.1093/jbcr/irz085 ◽

2019 ◽

Vol 40 (5) ◽

pp. 714-717 ◽

Cited By ~ 9

Author(s):

Bruno Almeida Costa ◽

Edmar Maciel Lima Júnior ◽

Manoel Odorico de Moraes Filho ◽

Francisco Vagnaldo Fechine ◽

Maria Elisabete Amaral de Moraes ◽

...

Keyword(s):

Low Cost ◽

Total Body Surface Area ◽

Morphological Structure ◽

Treatment Center ◽

Burn Treatment ◽

Partial Thickness ◽

Institutional Review ◽

Partial Thickness Burn ◽

The Face ◽

Pediatric Burns

Abstract Burns represent the fifth most common cause of nonfatal childhood injuries in the world. The Nile tilapia skin (Oreochromis niloticus) is widely available in Brazil and demonstrated, in previous studies, noninfectious microbiota, morphological structure similar to that of human skin, and good outcomes when used as a xenograft for treatment of experimental burns in rats. A 3-year-old boy was admitted to a burn treatment center in Fortaleza, Brazil, with scalds in the left side of the face, neck, anterior thorax, abdomen, and left arm. Involvement of 18% of total body surface area with superficial partial thickness burns was calculated. After local Institutional Review Board approval and written permission from the patient’s legal caregiver were obtained, application of tilapia skin as an occlusive dressing was performed. Good adherence of tilapia skin to the wound bed was detected. The patient was discharged from the hospital with a total of 10 days required for the complete re-epithelialization of his superficial partial thickness burn. No adverse effects were noted. We believe that further studies conducted by our researchers will allow this innovative, low-cost, widely available and easy to apply biomaterial to firm itself as a relevant option in the therapeutic arsenal of pediatric burns, producing significant social and financial impact for the health system.

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Porcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review

Medicina ◽

10.3390/medicina57050432 ◽

2021 ◽

Vol 57 (5) ◽

pp. 432

Author(s):

Herbert L. Haller ◽

Sigrid E. Blome-Eberwein ◽

Ludwik K. Branski ◽

Joshua S. Carson ◽

Roselle E. Crombie ◽

...

Keyword(s):

Healing Time ◽

Subsequent Treatment ◽

Skin Substitute ◽

Skin Substitutes ◽

Burn Treatment ◽

Advantages And Disadvantages ◽

Partial Thickness ◽

Partial Thickness Burn ◽

Partial Thickness Burns ◽

Porcine Xenograft

Background and Objectives: Porcine xenografts have been used successfully in partial thickness burn treatment for many years. Their disappearance from the market led to the search for effective and efficient alternatives. In this article, we examine the synthetic epidermal skin substitute Suprathel® as a substitute in the treatment of partial thickness burns. Materials and Methods: A systematic review following the PRISMA guidelines has been performed. Sixteen Suprathel® and 12 porcine xenograft studies could be included. Advantages and disadvantages between the treatments and the studies’ primary endpoints have been investigated qualitatively and quantitatively. Results: Although Suprathel had a nearly six times larger TBSA in their studies (p < 0.001), it showed a significantly lower necessity for skin grafts (p < 0.001), and we found a significantly lower infection rate (p < 0.001) than in Porcine Xenografts. Nonetheless, no significant differences in the healing time (p = 0.67) and the number of dressing changes until complete wound healing (p = 0.139) could be found. Both products reduced pain to various degrees with the impression of a better performance of Suprathel® on a qualitative level. Porcine xenograft was not recommended for donor sites or coverage of sheet-transplanted keratinocytes, while Suprathel® was used successfully in both indications. Conclusion: The investigated parameters indicate that Suprathel® to be an effective replacement for porcine xenografts with even lower subsequent treatment rates. Suprathel® appears to be usable in an extended range of indications compared to porcine xenograft. Data heterogeneity limited conclusions from the results.

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Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study

Journal of Burn Care & Research ◽

10.1093/jbcr/irz149 ◽

2019 ◽

Cited By ~ 1

Author(s):

Edmar Maciel Lima Júnior ◽

Manoel Odorico de Moraes Filho ◽

Antonio Jorge Forte ◽

Bruno Almeida Costa ◽

Francisco Vagnaldo Fechine ◽

...

Keyword(s):

Pilot Study ◽

Test Group ◽

Silver Sulfadiazine ◽

Control Group ◽

Burn Wound ◽

Open Label ◽

Burn Treatment ◽

Partial Thickness ◽

Partial Thickness Burn ◽

Partial Thickness Burns

Abstract This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial “partial-thickness” burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.

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Lubricant and razor debridement in partial thickness burn

Burns ◽

10.1016/j.burns.2005.04.010 ◽

2005 ◽

Vol 31 (7) ◽

pp. 915-917 ◽

Cited By ~ 2

Author(s):

Luca A. Dessy ◽

M. Dalvi Humzah ◽

Raul L.M. Ranno ◽

Carmine Alfano

Keyword(s):

Partial Thickness ◽

Partial Thickness Burn

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Amnion Membrane Graft Dressing in Superficial Partial Thickness Burn in Pediatric Patients

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v14i1.22875 ◽

2015 ◽

Vol 14 (1) ◽

pp. 22-25

Author(s):

Md Saif Ullah ◽

KMN Ferdous ◽

Md Mobassar Hussain Mullick ◽

Md Rashedul Alam ◽

Md Sazzaduar Rahman ◽

...

Keyword(s):

Amniotic Membrane ◽

Pediatric Patients ◽

Cost Effective ◽

Skin Substitutes ◽

Protein Loss ◽

Change Rate ◽

Partial Thickness ◽

Partial Thickness Burn ◽

Amnion Membrane ◽

Dressing Change

Objective: The aim of this study was to find out the effectiveness of amniotic membrane graft dressing in the treatment of superficial partial thickness burn in children. Methods: The retrospective study was conducted on the patients admitted with superficial partial thickness burn in the burn unit of Dhaka Shishu Hospital age 0-12 years, during the period from January 1999 to December 2011. All of them treated with amnion membrane graft dressing. Results: Total 370 patients were included in this study. Mean age was 2.76 years. Amnion dressing suppresses bacteria in the wound as well as reduced infection. Amnions have good adherent characteristics, which reduced infection as well as reduction of oozing of plasma from the wound, that become dry early. It has a role on burnt pain reduction, Frequency of dressing change, rate of healing, cost, duration hospital stay. Conclusion: Our experience showed that amniotic membrane is one of the effective biological skin substitutes used in burn wounds, with efficacy of low bacterial counts, has advantageous of reducing protein loss, electrolytes & fluids. Decreasing the risk of infection minimizing pain, accelerate of wound healing and good handling properties. It is ready available does not present immunological problem and allergies response. It is cost effective and very helpful for developing countries. DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22875 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 22-25

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