Role of selective V1a receptor agonism in ovine septic shock*

2011 ◽  
Vol 39 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Sebastian Rehberg ◽  
Christian Ertmer ◽  
Jean-L. Vincent ◽  
Andrea Morelli ◽  
Mareike Schneider ◽  
...  
Keyword(s):  
Septic Shock ◽  
V1a Receptor

The Role of IL-1, IL-6, TNF-α and MIF in Relative Adrenal Insufficiency in Septic Shock: A Study in Piglet Model

2018 ◽  
Author(s):  
Bina Akura ◽  
Jose Batubara ◽  
Zakiudin Munasir ◽  
Gunati unknown ◽  
Joedo Prihartono ◽  
...  
Keyword(s):  
Septic Shock ◽  
Adrenal Insufficiency ◽  
Relative Adrenal Insufficiency ◽  
Tnf Α

The Role of Histones and Heparin in Sepsis: A Review

2021 ◽  
pp. 088506662199232
Author(s):  
Xiaojuan Zhang ◽  
Xin Li
Keyword(s):  
Septic Shock ◽  
Multiple Organ ◽  
Clinical Settings ◽  
The Past ◽  
Life Saving ◽  
Extracellular Histones ◽  
Sepsis And Septic Shock ◽  
Development And Management ◽  
Made In

Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into the extracellular space. Heparin, a commonly used anti-coagulant, has been shown to possess life-saving capabilities for septic patients, but the potential interplay between heparin and extracellular histones has not been investigated. In this review, we summarize the pathogenic roles of extracellular histones and the therapeutic roles of heparin in the development and management of sepsis and septic shock.

The role of corticosteroid in septic shock patients

2018 ◽  
Vol 43 ◽  
pp. 386
Author(s):  
Chen-Tse Lee ◽  
Yu-Chang Yeh
Keyword(s):  
Septic Shock

scholarly journals Reevaluating the Role of Corticosteroids in Septic Shock: An Updated Meta-Analysis of Randomized Controlled Trials

2018 ◽  
Author(s):  
Xingji Lian ◽  
Daozheng Huang ◽  
Yinshu Cao ◽  
Yanxing Wei ◽  
Zhiwen Lian ◽  
...  
Keyword(s):  
Septic Shock ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals THE ROLE OF MOFS IN OUTCOME IN PATIENTS WITH SEPTIC SHOCK

2018 ◽  
Vol 7 (06) ◽  
pp. 729-732
Author(s):  
Vikas Garg ◽  
Anju Bhagtana ◽  
Jyoti Garg ◽  
Nain P S
Keyword(s):  
Septic Shock
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