scholarly journals Associations of mid-childhood bisphenol A and bisphenol S exposure with mid-childhood and adolescent obesity

2021 ◽  
Vol 6 (1) ◽  
pp. e187
Author(s):  
Priya Gajjar ◽  
Yun Liu ◽  
Nan Li ◽  
Jessie P. Buckley ◽  
Aimin Chen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adolescent Obesity ◽  
Bisphenol S ◽  
Childhood And Adolescent Obesity

scholarly journals Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites

2017 ◽  
Vol 44 ◽  
pp. 287-302 ◽  
Author(s):  
Lalith Perera ◽  
Yin Li ◽  
Laurel A. Coons ◽  
Rene Houtman ◽  
Rinie van Beuningen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bisphenol A ◽  
Potential Interaction ◽  
Bisphenol S ◽  
Interaction Sites ◽  
Bisphenol Af ◽  
Stimulation Of

Bisphenol A, Bisphenol AF, and Bisphenol S - A comparison of pre- and postnatal endpoints

2018 ◽  
Vol 80 ◽  
pp. 32
Author(s):  
Vicki L. Sutherland ◽  
Barry McIntyre ◽  
Helen Cunny ◽  
Suramya Waidyanatha ◽  
Jui-Hua Hsieh ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Bisphenol Af

High Levels of Bisphenol A and Bisphenol S in Brazilian Thermal Paper Receipts and Estimation of Daily Exposure

2015 ◽  
Vol 78 (18) ◽  
pp. 1181-1188 ◽  
Author(s):  
Bruno Alves Rocha ◽  
Lara Ferreira Azevedo ◽  
Matheus Gallimberti ◽  
Andres Dobal Campiglia ◽  
Fernando Barbosa
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Daily Exposure ◽  
Thermal Paper

scholarly journals Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

2021 ◽  
Author(s):  
Tomas Prudencio ◽  
Luther Swift ◽  
Devon Guerrelli ◽  
Blake Cooper ◽  
Marissa Reilly ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Safety Profile ◽  
Intracellular Signaling ◽  
Cardiac Electrophysiology ◽  
Field Potential ◽  
Production Volume ◽  
Bisphenol S ◽  
Bisphenol F ◽  
Bisphenol Analogues ◽  
Whole Heart

ABSTRACTBackgroundBisphenol A (BPA) is a high-production volume chemical that is commonly used to manufacture consumer and medical-grade plastic products. Due to its ubiquity, the general population can incur daily environmental exposure to BPA, while heightened BPA exposure has been reported in intensive care patients and industrial workers. Due to health concerns, structural analogues are being explored as replacements for BPA.ObjectiveThis study aimed to examine the direct nongenomic effects of BPA on cardiac electrophysiology and compare its safety profile to recently developed alternatives, including BPS (bisphenol S) and BPF (bisphenol F).MethodsWhole-cell voltage-clamp recordings were performed on cell lines transfected with Nav1.5, hERG, or Cav1.2. Results of single channel experiments were validated by conducting electrophysiology studies on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and intact, whole heart preparations.ResultsOf the chemicals tested, BPA was the most potent inhibitor of both fast (INa-P) and late (INa-L) sodium channel (IC50 = 55.3 and 23.6 μM, respectively), L-type calcium channel (IC50 = 30.8 μM) and hERG channel current (IC50 = 127 μM). The inhibitory effects of BPA and BPF on L-type calcium channels were supported by microelectrode array recordings, which revealed shortening of the extracellular field potential (akin to QT interval). Further, BPA and BPF exposure impaired atrioventricular conduction in intact, whole heart experiments. BPS did not alter any of the cardiac electrophysiology parameters tested.DiscussionResults of this study demonstrate that BPA and BPF exert an immediate inhibitory effect on cardiac ion channels, and that BPS may be a safer alternative. Intracellular signaling or genomic effects of bisphenol analogues were not investigated; therefore, additional mechanistic studies are necessary to fully elucidate the safety profile of bisphenol analogues on the heart.

Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance

2014 ◽  
Vol 188 ◽  
pp. 21-24 ◽  
Author(s):  
Ghada M. Anwar ◽  
Gamal Yamamah ◽  
Amani Ibrahim ◽  
Dalia El-Lebedy ◽  
Tarek M. Farid ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Food Intake ◽  
Adolescent Obesity ◽  
Childhood And Adolescent Obesity
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