Robotic Donor Hysterectomy Results in Technical Success and Live Births After Uterus Transplantation

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
LIZA JOHANNESSON ◽  
ANJI WALL ◽  
JOHANNA BAYER ◽  
GREG J. MCKENNA ◽  
MATTHEW ROSENZWEIG ◽  
...  
Keyword(s):  
Technical Success ◽  
Uterus Transplantation ◽  
Live Births

scholarly journals Fetal Cardiac Interventions—Polish Experience from “Zero” to the Third World Largest Program

2020 ◽  
Vol 9 (9) ◽  
pp. 2888
Author(s):  
Marzena Debska ◽  
Adam Kolesnik ◽  
Beata Rebizant ◽  
Agnieszka Sekowska ◽  
Agnieszka Grzyb ◽  
...  
Keyword(s):  
Death Rate ◽  
Third World ◽  
Technical Success ◽  
Technical Aspects ◽  
Technical Success Rate ◽  
Live Births ◽  
The Third ◽  
Polish Experience ◽  
Gestational Age At Delivery ◽  
The Third World

This article presents the technical aspects of the Polish fetal cardiac interventions (FCI) program, including preparation of the team and modifications in the technique of the procedure that aim to increase its safety for the mother and the fetus. Over 9 years, 128 FCI in 113 fetuses have been performed: 94 balloon aortic valvuloplasties (fBAV), 14 balloon atrioseptoplasties (fBAS) with stent (BAS+), 5 balloon atrioseptoplasties without stent placement (BAS−), and 15 fetal pulmonary valvuloplasties (fBPS). The technical success rate ranged from 80% (BAS−) to 89% (fBAV), while the procedure-related death rate (defined as death within 72 hours following the procedure) ranged from 7% (fBAV and fBPV) to 20% (BAS). There were 98 live births after all FCI (3 pregnancies continue). Median gestational age at delivery was 39 weeks in our center and 38 weeks in other centers.

scholarly journals Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success

2017 ◽  
Vol 17 (11) ◽  
pp. 2901-2910 ◽  
Author(s):  
G. Testa ◽  
E. C. Koon ◽  
L. Johannesson ◽  
G. J. McKenna ◽  
T. Anthony ◽  
...  
Keyword(s):  
Living Donor ◽  
Lessons Learned ◽  
Technical Success ◽  
Uterus Transplantation

scholarly journals 612 Uterus Transplantation: An Overview

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
S L Yao ◽  
N Hammond-Browning
Keyword(s):  
Ethical Issues ◽  
Graft Thrombosis ◽  
Uterus Transplantation ◽  
Medical Databases ◽  
Live Births ◽  
Biological Children ◽  
Uterine Transplantation ◽  
History Of ◽  
Vessel Thrombosis

Abstract Introduction Uterine transplantation (UTx) allows women with abnormal uterine factor infertility (AUFI) to have their own biological children. UTx use both living and deceased donations (LD and DD), and once transplanted, embryos fertilised through IVF are implanted. The aims of this review are to summarise the history of UTx and discuss the ethical issues surrounding immunosuppression and living donations for a ‘life enhancing’ transplant. Method Data on UTx, clinical trials and resulting births was found by conducting a literature search on PubMed and other medical databases. Additionally, newspaper articles, institutional press releases and conference proceedings were used as some of the data is yet to be published. Results 72 UTx have been performed which have resulted in 29 live births. The first LD UTx was performed in 2000 but was removed due to graft thrombosis. The first live births from LD and DD UTx were achieved in 2014 and 2017 respectively. Conclusions Live births provide proofs of concept of UTx. Graft rejection, vessel thrombosis and infection are amongst reasons for graft failure. Development of an international registry for UTx is important to monitor the progress of all transplants in the long term to determine its medical and ethical feasibility as a treatment for AUFI.

LIVE BIRTHS AFTER UTERUS TRANSPLANTATION: REPORT OF THE FIRST SIX DELIVERIES AT A SINGLE CENTER—DUETS (DALLAS UTERUS TRANSPLANT STUDY)

2020 ◽  
Vol 114 (3) ◽  
pp. e261-e262
Author(s):  
Liza Johannesson ◽  
J. Michael Putman ◽  
Lilly Zhang ◽  
E. Colin Koon ◽  
Zachary S. Rubeo ◽  
...  
Keyword(s):  
Single Center ◽  
Uterus Transplantation ◽  
Live Births

Twelve Live Births After Uterus Transplantation in the Dallas UtErus Transplant Study

2021 ◽  
Vol 137 (2) ◽  
pp. 241-249
Author(s):  
Liza Johannesson ◽  
Giuliano Testa ◽  
J. Michael Putman ◽  
Gregory J. McKenna ◽  
E. Colin Koon ◽  
...  
Keyword(s):  
Uterus Transplantation ◽  
Live Births

scholarly journals Human Uterus Transplantation from Living and Deceased Donors: The Interim Results of the First 10 Cases of the Czech Trial

2021 ◽  
Vol 10 (4) ◽  
pp. 586
Author(s):  
Jiri Fronek ◽  
Jakub Kristek ◽  
Jaroslav Chlupac ◽  
Libor Janousek ◽  
Michael Olausson
Keyword(s):  
Herpes Simplex ◽  
Acute Rejection ◽  
Live Donor ◽  
Human Uterus ◽  
Uterus Transplantation ◽  
Live Births ◽  
Live Donors ◽  
Simplex Infection ◽  
Deceased Donors ◽  
One Year

Introduction: Uterus transplantation (UTx) is a rapidly evolving treatment of uterine-factor infertility. We report the results of the first 10 UTx procedures performed at our institution. Methods: The program started in April 2016 as a two-arm study comparing the efficacy of UTx from live donors (LD) and deceased donors (DD). Results: Between April 2016 and April 2018, we performed five DD UTx and five LD UTx. Two grafts had to be removed early due to thrombosis. One graft was removed due to chronic rejection and previous herpes simplex infection at month 7. Graft survival is 70% at one year. Recipient survival is 100% at two years. Live donor survival is 100% at three years. Three live-births have been achieved, two from a LD and one from a graft from a nulliparous DD. Vaginal anastomotic stenosis occurred in 63% (5/8) of grafts. Self-expanding stents have shown preliminary suitability for the treatment of vaginal stenosis. Three recipients developed severe acute rejection. Conclusion: The interim results of our study demonstrate mid-term viability in 70% of grafts. The LD UTx produced two live births and the DD UTx produced one live birth. Nulliparous donors should be considered for donation.

Research outcomes following uterus transplantation at Royal Prince Alfred Hospital

2020 ◽  
Vol 29 (3) ◽  
Author(s):  
Dana Georgevsky ◽  
Ying Li ◽  
Kate Wyburn ◽  
Selvan Pather ◽  
Trevor TejadaBerges ◽  
...  
Keyword(s):  
Uterus Transplantation ◽  
Royal Prince Alfred Hospital ◽  
Research Outcomes ◽  
Alfred Hospital
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