Vaginal progesterone suppositories did not boost the number of live births in women with recurrent miscarriage

2016 ◽  
Author(s):  
Keyword(s):  
Recurrent Miscarriage ◽  
Live Births ◽  
Vaginal Progesterone

Increased live births among patients using intamuscular versus vaginal progesterone for luteal phase support during frozen blastocyst transfer

2013 ◽  
Vol 100 (3) ◽  
pp. S459-S460 ◽  
Author(s):  
R.J. Heitmann ◽  
K.S. Richter ◽  
K. Devine ◽  
J. McKeeby ◽  
A.H. DeCherney ◽  
...  
Keyword(s):  
Luteal Phase ◽  
Blastocyst Transfer ◽  
Luteal Phase Support ◽  
Live Births ◽  
Vaginal Progesterone

scholarly journals Live Birth Rates after Active Immunization with Partner Lymphocytes

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1350
Author(s):  
Veronika Günther ◽  
Ibrahim Alkatout ◽  
Lisa Meyerholz ◽  
Nicolai Maass ◽  
Siegfried Görg ◽  
...  
Keyword(s):  
Live Birth ◽  
Recurrent Miscarriage ◽  
Active Immunization ◽  
Birth Rates ◽  
Live Births ◽  
Live Birth Rates ◽  
History Of ◽  
The Difference ◽  
Immunological Risk Factors ◽  
Routine Therapy

Although many potential causes have been established for recurrent implantation failure (RIF) and recurrent miscarriage (RM), about 50% of these remain idiopathic. Scientific research is focused on immunological risk factors. In the present study, we aim to evaluate live birth rates after immunization with paternal lymphocytes (lymphocyte immunotherapy (LIT)). This retrospective study consisted of 148 couples with a history of RM and/or RIF. The women underwent immunization with lymphocytes of their respective partners from November 2017 to August 2019. Fifty-five patients (43%) had live births. Stratified by indication (RM, RIF, combined), live birth rates in the RM and the combined group were significantly higher than that in the RIF group (53%, 59% and 33%, respectively, p = 0.02). The difference was especially noticeable during the first 90 days after immunization (conception rate leading to live births: 31%, 23% and 8% for RM, the combined group and RIF, respectively; p = 0.005), while there was no difference between groups during the later follow-up. LIT was associated with high live birth rates, especially in women with recurrent miscarriage. In view of the limited data from randomized studies, LIT cannot be recommended as routine therapy. However, it may be considered in individual cases.

Parental karyotype and subsequent live births in recurrent miscarriage

2004 ◽  
Vol 81 (5) ◽  
pp. 1296-1301 ◽  
Author(s):  
Howard Carp ◽  
Baruch Feldman ◽  
Gabriel Oelsner ◽  
Eyal Schiff
Keyword(s):  
Recurrent Miscarriage ◽  
Live Births

scholarly journals H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births

2010 ◽  
Vol 25 (11) ◽  
pp. 2745-2752 ◽  
Author(s):  
H. S. Nielsen ◽  
F. Wu ◽  
Z. Aghai ◽  
R. Steffensen ◽  
A. G. van Halteren ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Female Ratio ◽  
Live Births ◽  
Male Female Ratio ◽  
Antibody Titers

scholarly journals Recurrent pregnancy loss: challenge to obstetricians

2017 ◽  
Vol 6 (8) ◽  
pp. 3376
Author(s):  
Mamatha B. Shetty ◽  
Mounica Malyala ◽  
Asha Swarup ◽  
Suneha Pocha ◽  
Davis Sabu Pathadan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Recurrent Miscarriage ◽  
Laboratory Data ◽  
Difficult Situation ◽  
Live Births ◽  
Medical College ◽  
Cervical Incompetence ◽  
Study Results

Background: Recurrent pregnancies loss (RPL) is physically and emotionally devastating situation for the parents, along with difficult situation for obstetrician to handle. Present study aimed at investigation of the significance of various etiology in relation to pregnancy outcome in cases of recurrent pregnancy loss.Methods: It is a retrospective analysis of patients who presented to M. S. Ramaiah Medical college with recurrent miscarriage between April 2014 and August 2015. ANA was done on the basis of clinical and laboratory data which was obtained and eventually diagnosis was made. The study results were analysed in terms of term live births, maternal and fetal complications.Results: Out of the RPL cases that were studied, 78 patients came with recurrent pregnancy loss. Out of these cases, endocrine abnormalities, like diabetes mellitus and hypothyroidism were the maximum 26.92% and 12.82% respectively. Followed by unexplained causes were 37.3%. Thrombophila and APLA positive cases constituted for 16.66% and 3.4% respectively. ANA positive and cervical incompetence were 6.4% each.Conclusions: Recurrent pregnancy loss is very difficult situation to handle. Various etiology need various specialists, and requirements, and management mainly depends on the cause for recurrent pregnancy loss.

scholarly journals Assessment of Sub-endometrial Blood Flow Parameters Following Oral Dydrogesterone versus Micronized Vaginal Progesterone in Women with Idiopathic Recurrent Miscarriage

2021 ◽  
pp. 69-83
Author(s):  
Magda I. Nasr ◽  
Mona K. Omar ◽  
Walid M. Ataallah ◽  
Amal E. Mahfouz
Keyword(s):  
Blood Flow ◽  
Pregnant Women ◽  
Recurrent Miscarriage ◽  
Study Groups ◽  
Control Group ◽  
Flow Parameters ◽  
Vaginal Progesterone ◽  
Uteroplacental Blood Flow ◽  
Group A ◽  
The Mean

Background: Recurrent pregnancy loss is an important reproductive health issue, affecting 2%–5% of couples. An unsupportive endometrium, leading to abnormal implantation, is considered to be one of the key factors contributing to idiopathic recurrent spontaneous miscarriage (IRSM). The aim of this work was to evaluate differences in uteroplacental blood flow and pregnancy outcome in women with idiopathic recurrent spontaneous miscarriage (IRSM) following administration of micronized vaginal progesterone versus oral dydrogesteron. Materials and Methods: This prospective, randomized-controlled study comprised 90 pregnant women who came to outpatient clinic of obstetrics  .All women had a singleton pregnancy with active cardiac pulsations at gestational age between 5-8 weeks Pregnant women in the study group were randomly distributed into: Group {A}: 30 pregnant women received 10 mg of oral dydrogesterone (Duphaston; Abbott Company) twice daily.Group {B}: 30 pregnant women received 200 mg micronized vaginal progesterone (Prontogest) twice-daily. Control group:30 pregnant women without history of recurrent miscarriage served as controls and they received folic acid as placebo. Results: comparing the Doppler indices before progesterone supplementation, the mean resistance index (RI) was statistically significant less in the control group compared with both study groups (A&B) (P=0.012, P=0.005 respectively) .Moreover, pulsatility index (PI) was statistically significant less in the control group compared with both study groups (A&B) (P=0.026, P=0.05 respectively) .Paralleled to that, the S/D ratio was statistically significant less in control group compared with both group A &B (P=0.43, & P=0.019respectively) .In addition, the mean PSV was significantly higher in control group  compared to group B (P=0.047) and was higher in control group than group A with nearly significant P value. Conclusion: Considerable improvement in uteroplacental blood flow parameters of pregnant women with IRSM is evident with progesterone supplementation.

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