IATROGENIC OCCLUSION OF THE OPHTHALMIC ARTERY AFTER SODIUM TETRADECYL SULFATE INJECTION IN THE FOREHEAD

Retinoblastoma is the most frequent ocular malignancy in the pediatric population and intra-arterial chemotherapy has emerged as the first-line treatment of this entity with cure rates ranging from 33–100%, depending on the severity of the disease. We present the case of an advanced retinoblastoma in a pediatric patient who underwent intra-arterial chemotherapy through a contralateral route due to unsuccessful catheterization of the ophthalmic artery. The patient was diagnosed with a class D retinoblastoma which underwent the catheterization of the ophthalmic artery through the contralateral internal carotid and through the anterior communicating artery. In this case, intra-arterial chemotherapy administration was successfully delivered without complications. Contralateral routes for intra-arterial chemotherapy are safe and allow adequate penetration of the chemotherapeutic drugs in cases where a well-developed anterior communicating artery is present.

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Successful Treatment of Massive Choroidal Invasion in Retinoblastoma with Intraarterial Chemotherapy (Ophthalmic Artery Chemosurgery)

Ophthalmology Retina ◽

10.1016/j.oret.2020.12.018 ◽

2020 ◽

Author(s):

David H. Abramson ◽

Y. Pierre Gobin ◽

Ira J. Dunkel ◽

Jasmine H. Francis

Keyword(s):

Successful Treatment ◽

Ophthalmic Artery ◽

Intraarterial Chemotherapy ◽

Choroidal Invasion

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BRTO vs PARTO for gastric variceal bleeding using sodium tetradecyl sulfate (STS) in a single U.S. medical center

Journal of Vascular and Interventional Radiology ◽

10.1016/j.jvir.2016.12.1005 ◽

2017 ◽

Vol 28 (2) ◽

pp. S165-S166

Author(s):

R Charalel ◽

N Saad ◽

S Kim

Keyword(s):

Variceal Bleeding ◽

Medical Center ◽

Sodium Tetradecyl Sulfate

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Sclerotherapy of telangiectasias: A prospective, randomized, comparative clinical trial of hypertonic glucose versus sodium tetradecyl sulfate

Vascular Medicine ◽

10.1177/1358863x21992853 ◽

2021 ◽

pp. 1358863X2199285

Author(s):

Oksana Vasilyevna Bukina ◽

Aleksander Aleksandrovich Sinitsyn ◽

Andrey Viktorovich Pelevin

Keyword(s):

Clinical Trial ◽

Sodium Tetradecyl Sulfate ◽

Median Score ◽

Primary Efficacy ◽

Point Scale ◽

Prospective Randomized Clinical Trial ◽

Hypertonic Glucose ◽

Venous Diseases ◽

Group 3

To compare the disappearance of the telangiectasias after sclerotherapy with 75% glucose (HG) versus 0.2% sodium tetradecyl sulfate (STS). This prospective, randomized clinical trial compared the results of sclerotherapy of the telangiectasias with HG and STS. The primary efficacy end point was telangiectasia disappearance within 14, 28, 42, and 56 days following treatment. The clearing of the vessels was assessed using a six-point scale (from 0 to 5). A total of 159 women were treated (81 in the STS group; 78 in the HG group). The median score of the vessels clearing (IQR) was significantly lower in the STS group than in the HG group: 3 (2–4) versus 4 (3–5) after 56 days, p < 0.001. Pigmentation was frequently observed in the STS group (38.3% vs 2.6%; p < 0.001). In conclusion, throughout the entire follow-up period, sclerotherapy of telangiectasias with glucose was significantly superior to that with STS. Moreover, pigmentation and intravascular clots frequently occurred with STS treatment. Registered at the Russian Registry of Treatment of Chronic Venous Diseases (RRT CVD); ID: VRCVD 1.005.

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Risk factors for ophthalmic artery stenosis and occlusion in patients with retinoblastoma treated with intra-arterial chemotherapy

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2021-319118 ◽

2021 ◽

pp. bjophthalmol-2021-319118

Author(s):

Min Zhou ◽

Xuyang Wen ◽

Shichong Jia ◽

Yanping Han ◽

Xiaoyu He ◽

...

Keyword(s):

Risk Factors ◽

Ophthalmic Artery ◽

Cox Regression ◽

Median Number ◽

Disease Stage ◽

Orifice Diameter ◽

Clinical Predictors ◽

Total Incidence ◽

Intraocular Retinoblastoma ◽

Stenosis And Occlusion

PurposeTo explore the risk factors for ophthalmic artery (OA) stenosis and occlusion after intra-arterial chemotherapy (IAC) with selective ophthalmic artery catheterisation (OAC) in the treatment of retinoblastoma.DesignRetrospective, single centre case-control study.MethodsThe study was conducted including consecutive patients with unilateral or bilateral intraocular retinoblastoma undergoing IAC between June 2016 and June 2019 with a follow-up time of 4 years. Main outcomes are rate of IAC-induced OA occlusion and OA diameter.Results346 attempted OAC infusions were successful. The total incidence of OA occlusion was 15.89%. The occlusion and control groups were similar in patients’ age, sex and disease stage. Median OA diameter was 0.49 mm in those with OA occlusion, and 0.66 mm in those without occlusion. In the occlusion group, the OA diameter difference was significantly larger between the first IAC and the final IAC (0.22mm vs 0.12mm, p=0.001). In both groups, the median number of IAC treatments was 3. Multivariate Cox regression models included initial OA diameter (OR: 0.005, p=0.001), ratio of OA orifice diameter differences between first and last IAC to the initial OA orifice diameter (OR: 4.661, p=0.003), and number of IAC (OR: 1.538, p=0.042) as clinical features significantly associated with OA occlusion.ConclusionsThe OA diameter at first IAC treatment, the ratio of OA orifice diameter differences between first and last IAC to the initial OA orifice diameter and total number of IAC treatments may be three main clinical predictors for OA occlusion after IAC for retinoblastoma.

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