Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion

Cornea ◽  
2015 ◽  
Vol 34 (10) ◽  
pp. 1259-1265 ◽  
Author(s):  
Rosalind C. Vo ◽  
Judy L. Chen ◽  
P. James Sanchez ◽  
Fei Yu ◽  
Anthony J. Aldave
2018 ◽  
Vol 15 (2) ◽  
pp. 176-181 ◽  
Author(s):  
S. V. Trufanov ◽  
A. A. Fedorov ◽  
V. R. Mamikonyan ◽  
L. Yu. Tekeeva ◽  
S. A. Malozhen ◽  
...  

Purpose: to develop the optimal (safe and effective) method of diamond burr polishing of Bowman’s membrane (DBPBM) for the possible use it in the treatment of the recurrent corneal erosion syndrome (RCES) in the experiment.Material and methods. DBPBM in different modifications of the  method and the mechanical deepithelization were performed in  experiment on 19 human cadaver eyes. We use system Ophtho-Burr  for DBPBM that includes a tip and ophthalmic burrs with diameter  1mm, 2.5 mm, 5 mm, varying the speed of rotation of burr. For 3  eyes — polishing with the application of burr with a diameter of 5  mm, the rotation frequency of 4000 rpm using 2 passes over the  surface of the cornea. For 3 eyes — burr with a diameter of 2.5 mm,  rotation frequency of 4000 rpm in 2 perpendicular passes. For 3 eyes — diameter burr 1 mm at speed of 8000 rpm in 2 perpendicular  passes. For 3 eyes — diameter burr 1 mm at speed 4000 rpm with 4  passes along the surface of the cornea. For 4 eyes — diameter was 1 mm at speed of 4000 rpm in 2 perpendicular passes. For 3 the eyes  was conducted mechanical deepithelization. Subsequent histopathological investigation of the cornea was  performed by method of semi-thin section, with polychrome staining.Results. The obtained results of histological studies of DBPBM in  different versions on cadaver cornea is allowed to choose the optimal variant of surgical intervention for use in clinical conditions. It  consisted in a selection of burr with a diameter of 1 mm, the rotation frequency of the 4000 rpm and 2 perpendicular passes with a  moderate compression of the cornea. The abovementioned technique of intervention allows removing completely the corneal epithelium  with a basal membrane and save uniform in thickness, fully  deepitelizationed Bowman’s membrane.Conclusion.Careful and accurate removal of dysplastic corneal epithelium in cases of the recurrent corneal erosion syndrome using  proposed method in clinical conditions should contribute to the  creation optimal environments for adequate reepithelization with  steady epithelial-stromal adhesion. The remaining nearly intact  Bowman’s membrane after procedure can prevent some postoperative complications such as haze and induced refractive disorders.


2019 ◽  
Vol 103 (9) ◽  
pp. 1204-1208 ◽  
Author(s):  
Shawn Rong Lin ◽  
Anthony J Aldave ◽  
James Chodosh

Recurrent corneal erosion syndrome (RCES) is a disorder characterised by a dysfunctional epithelial ecosystem. It often begins after trauma, or in the setting of epithelial basement membrane degeneration or dystrophy. Historically, RCES has been understood as a structural derangement of the anterior corneal architecture. More recently, studies have demonstrated the important role of neuropeptides in corneal homoeostasis. Thus, RCES may also be understood as a disorder of corneal epithelial cell biology. Management of RCES can be challenging, but newer therapies have demonstrated improved efficacy for this condition. This review examines the aetiology and pathogenesis of RCES, and provides an update on current and emerging treatment modalities for the management of this disorder.


2018 ◽  
Vol 134 (5) ◽  
pp. 162
Author(s):  
V. R. Mamikonyan ◽  
S. V. Trufanov ◽  
L. Yu. Tekeeva ◽  
S. A. Malozhen ◽  
A. M. Subbot ◽  
...  

Author(s):  
Oscar D. Guillamondegui

Traumatic brain injury (TBI) is a serious epidemic in the United States. It affects patients of all ages, race, and socioeconomic status (SES). The current care of these patients typically manifests after sequelae have been identified after discharge from the hospital, long after the inciting event. The purpose of this article is to introduce the concept of identification and management of the TBI patient from the moment of injury through long-term care as a multidisciplinary approach. By promoting an awareness of the issues that develop around the acutely injured brain and linking them to long-term outcomes, the trauma team can initiate care early to alter the effect on the patient, family, and community. Hopefully, by describing the care afforded at a trauma center and by a multidisciplinary team, we can bring a better understanding to the armamentarium of methods utilized to treat the difficult population of TBI patients.


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