The Quantitative Measurements of Vascular Density and Flow Area of Optic Nerve Head Using Optical Coherence Tomography Angiography

Abstract Purpose To measure optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) at various stages of diabetic retinopathy (DR). Methods One hundred seventy six eyes of 94 patients included in this retrospective single-centre cross-sectional study. The subjects were studied in normal, no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative retinopathy (PDR) groups. The eyes were subjected to AngioDisc ONH imaging using OCTA for papillary (Disc) and peripapillary (RPC) vascular density (VD) evaluation. Results The mean age of the participants was 56.08 ± 8.87 years and 34 (36.2 percent) were male. With increased DR severity, a statistically significant decrease in peripapillary VD was found. The study showed that only VD of the whole RPC (W-RPC) could be a valid biomarker in the staging assessment. VD of RPC, in all subsections, was considerably different from normal cases in the PDR group. Visual acuity was correlated with whole image ONH VD. The duration of DM, FBS, hyperlipidemia and DME had no effect on the ONH perfusion. Conclusions The study showed that only the W-RPC VD could be a reasonable marker in the staging assessment. VDs assessed by OCTA can be useful for assessing and tracking early ONH changes in DR patients.

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Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes

Journal of Glaucoma ◽

10.1097/ijg.0000000000000768 ◽

2017 ◽

Vol 26 (10) ◽

pp. 851-859 ◽

Cited By ~ 49

Author(s):

Patricia I.C. Manalastas ◽

Linda M. Zangwill ◽

Luke J. Saunders ◽

Kaweh Mansouri ◽

Akram Belghith ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optic Nerve Head ◽

Optical Coherence Tomography Angiography ◽

Vascular Density ◽

Optical Coherence ◽

Healthy Eyes

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Optic Nerve Head Optical Coherence Tomography Angiography Findings in Patients with Coronavirus Disease 2019

10.21203/rs.3.rs-181445/v1 ◽

2021 ◽

Author(s):

Mojtaba Abrishami ◽

Ramin Daneshvar ◽

Zahra Emamverdian ◽

Naser Shoeibi ◽

Shima Sedighi ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optic Nerve Head ◽

Optical Coherence Tomography Angiography ◽

Vascular Complications ◽

Control Group ◽

Vascular Density ◽

Optical Coherence ◽

Cross Sectional ◽

Normal Controls

Abstract Purpose: To quantify the microvasculature density of the optic nerve head (ONH) using optical coherence tomography angiography (OCTA) analysis.in patients recovered from Coronavirus Disease 2019 (COVID-19) Methods: In a comparative cross-sectional, observational study patients recovered from COVID-19, whom diagnosis of COVID-19 was confirmed by a positive reverse transcription-polymerase chain reaction of a nasopharyngeal sample were included in this study. The. OCTA of ONH was performed at least 2 weeks after recovery from systemic COVID-19. Vascular density (VD) of the all vessels (AV) and small vessels (SV) inside the disc and radial peripapillary capillary (RPC) network density were measured in COVID-19 recovered patients and compared with similar parameters in an age-matched group of normal controls.Results: Twenty-five COVID-19 patients and 22 age-matched normal controls were enrolled in the study and one eye per participant was evaluated. Mean whole image SV VD in the COVID-19 group (49.94 ± 2.22) was not statistically significantly different from that in the control group (49.31 ± 1.93; p-value= 0.308). An increase in RPC VD was found in all AV and SV VD measured, which became statistically significant in whole peripapillary SV VD, peripapillary inferior nasal SV VD, peripapillary inferior temporal SV VD, peripapillary superior nasal SV VD and grid-based AV VD inferior sector (p<0.05 for all comparisons).Conclusion: Unremarkable increase was found in ONH microvasculature in patients who had recovered from COVID-19. These patients may be at risk of ONH vascular complications.

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Assessment of optic nerve head parameters using optical coherence tomography angiography in behçet uveitis patients with healthy controls

Journal of Retina-Vitreous ◽

10.37845/ret.vit.2020.29.23 ◽

2020 ◽

Vol 29 (2) ◽

pp. 131

Author(s):

Melike BALIKOGLU ◽

Erdinc AYDIN ◽

Pinar NALCACIOGLU ◽

Nur DOGANAY KUMCU ◽

Seher SARITEPE IMREL ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optic Nerve Head ◽

Optical Coherence Tomography Angiography ◽

Healthy Controls ◽

Optical Coherence

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Study of peripapillary vascular flow using optical coherence tomography angiography in optic nerve head drusen

Clinical and Experimental Ophthalmology ◽

10.1111/ceo.13783 ◽

2020 ◽

Vol 48 (6) ◽

pp. 775-782 ◽

Cited By ~ 1

Author(s):

Mercedes Leal‐González ◽

Filipa Pessanha ◽

Martim Azevedo González‐Oliva ◽

Elia Pérez‐Fernández ◽

Pablo Gili

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optic Nerve Head ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Vascular Flow ◽

Optic Nerve Head Drusen

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Morphological and vascular characteristics of the optic nerve head in normal guinea pigs

10.21203/rs.3.rs-770084/v1 ◽

2021 ◽

Author(s):

Lei Guo ◽

Jun Tao ◽

Yang Tong ◽

Shichao Chen ◽

Xin Zhao ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optic Nerve Head ◽

Refractive Error ◽

Guinea Pigs ◽

Linear Regression Analysis ◽

Vascular Density ◽

Optical Coherence ◽

Vessel Length

Abstract The morphological and vascular characteristics of the optic nerve head (ONH) in normal guinea pigs remain unknown. Therefore, we aimed to investigate these parameters using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). We measured the refractive error, axial length, and intraocular pressure (IOP), and performed OCT and OCTA of the ONH in 3- and 4-week-old tricolour guinea pigs. A total of 208 right eyes from 208 normal guinea pigs were examined. The refractive error in the 3-week group was significantly larger than that in the 4-week group (p < 0.001), the IOP in the 3-week group was significantly lower than that in the 4-week group (p = 0.014), and the circumpapillary retinal nerve fibre layer (cpRNFL) thickness in the 3-week group was significantly larger than that in 4-week group (p = 0.048). There were no significant differences in the average vessel area, vascular density, total number of junctions, total vessel length, total number of endpoints, and vascular diameter between the two groups. However, an age-adjusted linear regression analysis revealed that total vessel length was positively associated with the cpRNFL thickness (p = 0.024) and negatively associated with IOP (p = 0.016). This is the first report on morphological and vascular characteristics of the ONH in normal guinea pigs based on in vivo OCT and OCTA imaging and quantification of ONH parameters. These results may contribute to further research on myopia and glaucoma using guinea pig models.

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Vascular Abnormalities in Peripapillary and Macular Regions of Behcet's Uveitis Patients Evaluated by Optical Coherence Tomography Angiography

Frontiers in Medicine ◽

10.3389/fmed.2021.727151 ◽

2021 ◽

Vol 8 ◽

Author(s):

Chun Yan ◽

Fan Li ◽

Min Hou ◽

Xiaoyuan Ye ◽

Lishi Su ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Vascular Density ◽

Optical Coherence ◽

Flow Area ◽

Vascular Abnormalities ◽

Behçet’S Uveitis ◽

Capillary Plexus ◽

Area And Perimeter ◽

Healthy Eyes

Purpose: To investigate the involvement of peripapillary zone vascular abnormalities in Behcet's uveitis (BU) and associated visual dysfunction. We evaluated the retinal and choroidal microvascular features in both macular and peripapillary areas of BU patients to identify vascular abnormalities contributing to reduced best-corrected visual acuity (BCVA) using optical coherence tomography angiography (OCTA).Methods: A prospective, observational study was conducted in 24 eyes of 13 patients with BU and 24 eyes of 15 healthy participants as controls. They received a standard eye examination and were recorded by OCTA measurements of macular and peripapillary areas. The vascular densities of superficial capillary plexus (SCP) and deep capillary plexus (DCP), choroidal flow area, radial peripapillary capillary network (RPCN) density, foveal avascular zone (FAZ) area and perimeter, full retinal thickness (FRT), and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured.Correlations among microvascular, structural, and functional changes were assessed.Results: Our findings uncovered that the vascular density was significantly reduced in the peripapillary zone of BU eyes compared to healthy eyes, especially in the inferior subfield of the RPCN. The vascular densities of SCP and DCP quadrants within the macular zone had no significant difference between BU and control groups except for DCP density of the nasal parafoveal quadrant. Both FAZ area and perimeter were greater but without statistical significance in the BU group. Compared to healthy eyes, the choriocapillaris flow area was smaller while the FRT and pRNFLT were greater in the BU group. Notably, there was a significant correlation between the reduction in RPCN vascular density and decreased BCVA in BU patients.Conclusion: Based on OCTA, vascular changes associated with BU are more prominent in the peripapillary zone than those in the macular zone. The vascular density of the RPCN could serve as a sensitive indicator to monitoring BU pathogenic progression and treatment response using a non-invasively method of OCTA.

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Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

European Journal of Ophthalmology ◽

10.1177/1120672119834472 ◽

2019 ◽

Vol 30 (4) ◽

pp. 756-763 ◽

Cited By ~ 7

Author(s):

José Ignacio Fernández-Vigo ◽

Bachar Kudsieh ◽

Ana Macarro-Merino ◽

Pedro Arriola-Villalobos ◽

José María Martínez-de-la-Casa ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Optic Nerve Head ◽

Optical Coherence Tomography Angiography ◽

Central Zone ◽

Vessel Density ◽

Optical Coherence ◽

Outer Retina ◽

Swept Source ◽

Capillary Plexus

Purpose: To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD). Methods: Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris. Reproducibility values were summarized as intraclass correlation coefficients (ICCs) and coefficients of variations (CV). Results: ICCs for the macular VD measurements in the central zone were 0.874, 0.770, 0.575, 0.718 at the levels SCP, DCP, outer retina, and choriocapillaris, respectively, while worse ICCs were obtained for the parafoveal subfields (ICC ⩽ 0.589); CVs were 2.8%–6.7%. The reproducibility of the ONH superficial VD was ICC = 0.941 for the papillary region and was ICC = 0.499–0.853 for the peripapillary zone; CVs ranged from 4.8% to 17%. Peripapillary VD showed an ICC = 0.533–0.770 in the DCP layer, and 0.572–0.828 in the choriocapillaris. Lowest VD were obtained for the macular SCP and DCP (23% and 22%, respectively), in the foveal zone, while greatest VD were recorded in the nasal and temporal peripapillary subfields at the level of the choriocapillaris (both 68%). Conclusions: The new SS-OCTA software served to quantify macular and ONH VD with a reproducibility that was good in the central zones (foveal and papillary, respectively) and moderate in the peripheral zones (parafoveal and peripapillary).

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