scholarly journals Potential Intussusception Risk Versus Benefits of Rotavirus Vaccination in the United States

2013 ◽  
Vol 32 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Rishi Desai ◽  
Margaret M. Cortese ◽  
Martin I. Meltzer ◽  
Manjunath Shankar ◽  
Jacqueline E. Tate ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Rotavirus Vaccination

Continued Evidence of the Impact of Rotavirus Vaccine in Children Less Than 3 Years of Age From the United States New Vaccine Surveillance Network: A Multisite Active Surveillance Program, 2006–2016

2020 ◽  
Author(s):  
Mary Allen Staat ◽  
Daniel C Payne ◽  
Natasha Halasa ◽  
Geoffrey A Weinberg ◽  
Stephanie Donauer ◽  
...  
Keyword(s):  
United States ◽  
Disease Burden ◽  
The United States ◽  
Population Based ◽  
Surveillance Program ◽  
Surveillance Network ◽  
Rotavirus Vaccination ◽  
Ed Visits ◽  
The Impact ◽  
Vaccine Surveillance

Abstract Background Since 2006, the New Vaccine Surveillance Network has conducted active, population-based surveillance for acute gastroenteritis (AGE) hospitalizations and emergency department (ED) visits in 3 United States counties. Trends in the epidemiology and disease burden of rotavirus hospitalizations and ED visits were examined from 2006 to 2016. Methods Children < 3 years of age hospitalized or visiting the ED with AGE were enrolled from January 2006 through June 2016. Bulk stool specimens were collected and tested for rotavirus. Rotavirus-associated hospitalization and ED visit rates were calculated annually with 2006–2007 defined as the prevaccine period and 2008–2016 as the postvaccine period. Rotavirus genotype trends were compared over time. Results Over 11 seasons, 6954 children with AGE were enrolled and submitted a stool specimen (2187 hospitalized and 4767 in the ED). Comparing pre- and postvaccine periods, the proportion of children with rotavirus dramatically declined for hospitalization (49% vs 10%) and ED visits (49% vs 8%). In the postvaccine era, a biennial pattern of rotavirus rates was observed, with a trend toward an older median age. G1P[8] (63%) was the predominant genotype in the prevaccine period with a significantly lower proportion (7%) in the postvaccine period (P < .001). G2P[4] remained stable (8% to 14%) in both periods, whereas G3P[8] and G12P[8] increased in proportion from pre- to postvaccine periods (1% to 25% and 17% to 40%), respectively. Conclusions The epidemiology and disease burden of rotavirus has been altered by rotavirus vaccination with a biennial disease pattern, sustained low rates of rotavirus in children < 3 years of age, and a shift in the residual genotypes from G1P[8] to other genotypes.

scholarly journals Infant Rotavirus Vaccination May Provide Indirect Protection to Older Children and Adults in the United States

2011 ◽  
Vol 204 (7) ◽  
pp. 980-986 ◽  
Author(s):  
Ben A. Lopman ◽  
Aaron T. Curns ◽  
Catherine Yen ◽  
Umesh D. Parashar
Keyword(s):  
United States ◽  
The United States ◽  
Older Children ◽  
Rotavirus Vaccination ◽  
Indirect Protection

Uptake, Impact, and Effectiveness of Rotavirus Vaccination in the United States

2011 ◽  
Vol 30 ◽  
pp. S56-S60 ◽  
Author(s):  
Jacqueline E. Tate ◽  
Margaret M. Cortese ◽  
Daniel C. Payne ◽  
Aaron T. Curns ◽  
Catherine Yen ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Rotavirus Vaccination

scholarly journals 93. Trends in the Laboratory Detection of Rotavirus Before and After Implementation of Routine Rotavirus Vaccination: the United States, 2000–2018

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S8-S8
Author(s):  
Benjamin D Hallowell ◽  
Umesh D Parashar ◽  
Aaron Curns ◽  
Nicholas DeGroote ◽  
Jacqueline Tate
Keyword(s):  
United States ◽  
Disease Burden ◽  
National Laboratory ◽  
The United States ◽  
Rotavirus Vaccine ◽  
Vaccine Introduction ◽  
Rotavirus Vaccination ◽  
Annual Peak ◽  
Before And After ◽  
Long Term Impact

Abstract Background Before the introduction of rotavirus vaccine in the United States in 2006, rotavirus infection was the leading cause of severe gastroenteritis among US children. Methods To evaluate the long-term impact of rotavirus vaccination on disease burden in the United States, CDC analyzed national laboratory testing data for rotavirus from laboratories participating in CDC’s National Respiratory and Enteric Viruses Surveillance System (NREVSS) during the pre- (2000–2006) and post-vaccine (2007–2018) periods. Results Nationally, the median annual percentage of positive rotavirus tests declined from 25.6% (range: 25.2–29.4%) in the pre-vaccine era to 6.1% (range: 2.6–11.1%) in the post-vaccine period. When comparing the pre- and post-vaccine era, the annual peak in rotavirus positivity declined from a median of 43.1% (range: 43.8–56.3%) to a median 14.0% (range: 4.8–27.3%) while the season duration was reduced from a median of 26 weeks (range: 23–27 weeks) to 9 weeks (range: 0–18 weeks). In the post-vaccine period, a biennial pattern emerged with alternating years of low and high rotavirus activity. Conclusion The implementation of rotavirus vaccine has dramatically reduced the disease burden and altered seasonal patterns of rotavirus in the United States; these changes have been sustained over 11 post-vaccine introduction seasons. Disclosures All Authors: No reported Disclosures.

Gastroenteritis Hospitalizations in Older Children and Adults in the United States Before and After Implementation of Infant Rotavirus Vaccination

JAMA ◽  
2013 ◽  
Vol 310 (8) ◽  
pp. 851 ◽  
Author(s):  
Paul A. Gastañaduy ◽  
Aaron T. Curns ◽  
Umesh D. Parashar ◽  
Ben A. Lopman
Keyword(s):  
United States ◽  
The United States ◽  
Older Children ◽  
Rotavirus Vaccination ◽  
Before And After

Cost-effectiveness and Potential Impact of Rotavirus Vaccination in the United States

PEDIATRICS ◽  
2007 ◽  
Vol 119 (4) ◽  
pp. 684-697 ◽  
Author(s):  
M.-A. Widdowson ◽  
M. I. Meltzer ◽  
X. Zhang ◽  
J. S. Bresee ◽  
U. D. Parashar ◽  
...  
Keyword(s):  
United States ◽  
Cost Effectiveness ◽  
The United States ◽  
Rotavirus Vaccination ◽  
Potential Impact
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