Abstract
Background
Many therapeutic options are currently available for facial skin rejuvenation, but little evidence exists about the efficacy of combining such procedures.
Objectives
To assess and investigate the synergic effect of HA and a-PRP injections on facial skin rejuvenation.
Methods
For this randomized controlled prospective study, 93 eligible patients were enrolled and randomized into three intervention groups to undergo a series of three treatments sessions with either a-PRP, HA or Cellular Matrix-BCT-HA (PRP-HA) injected on facial cheeks.
Results
A total of 93 patients were included. Treatment with Cellular Matrix BCT-HA led to a very significant improvement in the overall facial appearance compared to groups treated with a-PRP and HA alone (p<0.0001). Participants treated with Cellular Matrix showed a 20%, 24% and 17% increase in FACE-Q score at 1 month, 3 months and 6 months post-treatment, respectively. For the HA group, the improvement of FACE-Q score was 12%, 11% and 6% at 1, 3- and 6-months post-treatment, respectively, while the a-PRP group showed a 9% improvement in FACE-Q score at 1 month and 11% and 8% improvement at 3- and 6-months post-treatment, respectively.Biophysical measurements showed significantly improved skin elasticity for the group Cellular BCT-HA compared to a-PRP and HA alone. No serious adverse events were reported.
Conclusions
Combining a-PRP and HA seems to be a promising treatment for facial rejuvenation with a very significant improvement in facial appearance and skin elasticity compared to a-PRP or HA alone.
Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation
