Synergistic Effects of Autologous Platelet-Rich Plasma and Hyaluronic Acid Injections on Facial Skin Rejuvenation

2021 ◽  
Author(s):  
Barbara Hersant ◽  
Mounia SidAhmed-Mezi ◽  
Celine Aboud ◽  
Jeremy Niddam ◽  
Samuel Levy ◽  
...  
Keyword(s):  
Synergistic Effects ◽  
Platelet Rich Plasma ◽  
Post Treatment ◽  
Facial Appearance ◽  
Skin Elasticity ◽  
Facial Skin ◽  
Skin Rejuvenation ◽  
Serious Adverse Events ◽  
Autologous Platelet Rich Plasma ◽  
Cellular Matrix

Abstract Background Many therapeutic options are currently available for facial skin rejuvenation, but little evidence exists about the efficacy of combining such procedures. Objectives To assess and investigate the synergic effect of HA and a-PRP injections on facial skin rejuvenation. Methods For this randomized controlled prospective study, 93 eligible patients were enrolled and randomized into three intervention groups to undergo a series of three treatments sessions with either a-PRP, HA or Cellular Matrix-BCT-HA (PRP-HA) injected on facial cheeks. Results A total of 93 patients were included. Treatment with Cellular Matrix BCT-HA led to a very significant improvement in the overall facial appearance compared to groups treated with a-PRP and HA alone (p<0.0001). Participants treated with Cellular Matrix showed a 20%, 24% and 17% increase in FACE-Q score at 1 month, 3 months and 6 months post-treatment, respectively. For the HA group, the improvement of FACE-Q score was 12%, 11% and 6% at 1, 3- and 6-months post-treatment, respectively, while the a-PRP group showed a 9% improvement in FACE-Q score at 1 month and 11% and 8% improvement at 3- and 6-months post-treatment, respectively.Biophysical measurements showed significantly improved skin elasticity for the group Cellular BCT-HA compared to a-PRP and HA alone. No serious adverse events were reported. Conclusions Combining a-PRP and HA seems to be a promising treatment for facial rejuvenation with a very significant improvement in facial appearance and skin elasticity compared to a-PRP or HA alone.

Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: A split face study

2017 ◽  
Vol 16 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Heba I Gawdat ◽  
Amira M Tawdy ◽  
Rehab A Hegazy ◽  
Mohga M Zakaria ◽  
Ryham S Allam
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Skin Rejuvenation ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Split Face

Irreversible Blindness Following Periocular Autologous Platelet-Rich Plasma Skin Rejuvenation Treatment

2017 ◽  
Vol 33 ◽  
pp. S12-S16 ◽  
Author(s):  
Krishnapriya Kalyam ◽  
Shaheen C. Kavoussi ◽  
Michael Ehrlich ◽  
Christopher C. Teng ◽  
Nisha Chadha ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Rejuvenation ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Irreversible Blindness

scholarly journals The Addition of Tissue Stromal Vascular Fraction To Platelet-Rich Plasma Supplemented Lipofilling Does Not Improve Facial Skin Quality: A Prospective Randomized Clinical Trial

2021 ◽  
Author(s):  
Joris A van Dongen ◽  
Joeri v Boxtel ◽  
Joep C Willemsen ◽  
Linda A Brouwer ◽  
Karin M Vermeulen ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Therapeutic Effect ◽  
Water Loss ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Transepidermal Water Loss ◽  
Skin Aging ◽  
Skin Elasticity ◽  
Facial Skin ◽  
Skin Quality

Abstract Background Lipofilling has become popular as a treatment to improve aging related skin characteristics (eg, wrinkles, pigmentation spots, pores, or rosacea). Different additives such as platelet-rich plasma (PRP) or stromal vascular fraction (SVF) have been added to lipofilling to increase the therapeutic effect of adipose derived stromal cells (ASCs). Objectives In this study, we hypothesized that mechanical isolated SVF augments the therapeutic effect of PRP supplemented lipofilling to improve facial skin quality. Methods This prospective, double-blinded, placebo-controlled, randomized trial was conducted between 2016 and 2019. In total, 28 female subjects were enrolled with 25 completing the follow-up. All patients received PRP supplemented lipofilling with either mechanical isolated SVF or saline. SVF was isolated by means of the fractionation of adipose tissue (FAT) procedure (tissue-SVF). Results were evaluated by changes in skin elasticity and transepidermal water loss, changes in skin aging related features, ie, superficial spots, wrinkles, skin texture, pores, vascularity, and pigmentation as well as patient satisfaction (FACE-Q), recovery, and number of complications up to 1 year postoperative. Results The addition of tSVF to PRP supplemented lipofilling did not improve skin elasticity, transepidermal water loss nor skin aging related features. No improvement in patient satisfaction with overall facial appearance nor facial skin quality was seen when tSVF was added to PRP supplemented lipofilling. Conclusions PRP supplemented lipofilling with tSVF compared to PRP supplemented lipofilling alone does not improve facial skin quality nor patient satisfaction in a healthy population. PRP supplemented lipofilling with tSVF can be considered a safe procedure.

scholarly journals Complex Effects of Hot and Cold Procedures on Skin Elasticity in Spa & Wellness

2018 ◽  
Vol 14 (6) ◽  
pp. 1
Author(s):  
Nevenka Panovska ◽  
Antoaneta Dimitrova
Keyword(s):  
Age Groups ◽  
Skin Condition ◽  
Age Group ◽  
Skin Elasticity ◽  
Facial Skin ◽  
Skin Rejuvenation ◽  
The Third ◽  
Temperature Contrast ◽  
The Aesthetic

The purpose of this study is to evaluate the complex effects of the hot and cold procedures, practiced in modern Spa & Wellness, on skin elasticity, as that indicator is an integral factor defining the aesthetic vision of the skin. Material and Methods: The present study tracked 60 women aged 35 to 65 years. The methods included an aesthetic skin rejuvenation program that contained a complex of 12 Spa and Wellness rituals conducted in a period of one month, three times per week. Each treatment was а temperature contrast procedure through a Parafango body thermo-application and a face cryo-gel application. The facial skin condition was assessed by an A-ONE apparatus - an automatic skin diagnostic analyzer. Results: A significant improvement in the skin elasticity in the three studied age groups was observed after the procedures. This indicator increased 3.75 units (9.93%) in the 35-44 age group, 3.5 units (11.36%) in the 45-54 age-group and 1.80 units (8.22 %) in the observed individuals from 55-65 age-group. At the end of a treatment, the increase in all three age groups was statistically significant (p<0.05). Skin elasticity assessment was significantly lower for all three age-groups before the procedures, compared to the established standards. After the applied procedures, the skin elasticity was approaching the established standard (the first age group exceeded the standard, the second approached the standard and the third was slightly below the standard). Conclusion: The study reveals that the complex effects of hot and cold procedures result in improved skin elasticity.

Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation

2017 ◽  
Vol 43 (6) ◽  
pp. 826-835 ◽  
Author(s):  
Norma Cameli ◽  
Maria Mariano ◽  
Iole Cordone ◽  
Elva Abril ◽  
Serena Masi ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Facial Skin ◽  
Skin Rejuvenation

scholarly journals A pilot study: effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cheng-Yu Long ◽  
Kun-Ling Lin ◽  
Chin-Ru Shen ◽  
Chin-Ru Ker ◽  
Yi-Yin Liu ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Pilot Study ◽  
Stress Urinary Incontinence ◽  
Sexual Function ◽  
Treatment Effect ◽  
Platelet Rich Plasma ◽  
Post Treatment ◽  
Local Injection ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

AbstractThe study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effective in relieving SUI symptoms at both 1 month and 6 months post-treatment without significant adverse reactions reported. It seems to have a trend that treatment success rate with cured and improved symptoms was slightly higher in the younger group, although it did not reach statistical significance (P = 0.07). No significant changes in sexual function before and after the treatment were reported by the patients. This pilot study is the first to report A-PRP treatment effect for SUI in women. The result suggested that A-PRP is a considerable treatment option for mild to moderate SUI cases. It also opens up further research opportunities for A-PRP’s clinical applications.

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