scholarly journals MP29-06 USE OF AUTOLOGOUS RENAL CELLS FROM DISEASED KIDNEYS FOR THE TREATMENT OF RENAL FAILURE

2021 ◽  
Vol 206 (Supplement 3) ◽  
Author(s):  
Sunil George ◽  
Mehran Albolbashari ◽  
John Jackson ◽  
Tamer Aboushwareb ◽  
Anthony Atala ◽  
...  
Keyword(s):  
2019 ◽  
Vol 229 (4) ◽  
pp. e217
Author(s):  
Sunil George ◽  
John D. Jackson ◽  
Anthony Atala ◽  
James J. Yoo

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0164997 ◽  
Author(s):  
Sunil K. George ◽  
Mehran Abolbashari ◽  
John D. Jackson ◽  
Tamer Aboushwareb ◽  
Anthony Atala ◽  
...  

Author(s):  
B. N. Gadve ◽  
Sejal A. Patil

Chronic renal failure (CRF) is a threat to global health in general and for developing countries in particular. Globally CRF is the 12th highest cause of death. CRF is a progressive loss in renal function taking place over a period of months or years. This initially manifests only as a biochemical abnormality. CRF is considered when glomerular filtration rate (GFR) falls below 30ml/min. The conventional approach of management includes dialysis and renal transplantation, which are not affordable. Therefore, exploration of a safe and alternative therapy is needed. In Ayurveda, the disease can be consider as complication arising from various urinary disorders. A hampering of the function of basti, i.e. urine formation, results in the accumulation of several noxious products in circulation which need excreted management is aimed at eliminating these toxins, to protect the accessible renal cells rejuvenate the quiet cells. In Ayurveda several drugs are used as nephroprotective and this group of drug acts as good non- specific cytoprotectives. In this regard Ayurveda provides leads through its holistic line of management by in co-operative dietary and lifestyle invention and bio-balancing effects of Ayurvedic drugs.  


2012 ◽  
Vol 303 (3) ◽  
pp. F357-F365 ◽  
Author(s):  
Katherine J. Kelly ◽  
Jizhong Zhang ◽  
Mingsheng Wang ◽  
Shaobo Zhang ◽  
Jesus H. Dominguez

Acute kidney injury (AKI) and chronic renal failure (CKD) are the most challenging problems in nephrology. Multiple therapies have been attempted but these interventions have minimal effects on the eventual outcomes, and all too often the result is end-stage renal disease (ESRD). The only effective therapy for ESRD is renal transplantation but only a small fraction of patients receive transplants. In this work we introduce a novel approach to transplantation designed to regenerate kidneys afflicted by severe AKI or CKD: intravenous renal cell transplantation (IRCT) with adult rat primary renal cells reprogrammed to express the SAA gene localized and engrafted in kidneys of rat recipients that had severe AKI or CKD. IRCT significantly resolved renal dysfunction and limited kidney damage, inflammation, and fibrosis. Severe CKD was successfully improved by IRCT using kidney cells from donor rats or by renal cell self-donation in a form of autotransplantation. We propose that IRCT with adult primary renal cells reprogrammed to express the SAA gene can be used to effectively treat AKI and CKD.


2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Sharon C Presnell ◽  
Andrew Bruce ◽  
Shay M Wallace ◽  
Sumana Choudhury ◽  
Russell W Kelley ◽  
...  

2012 ◽  
Vol 188 (5) ◽  
pp. 2000-2006 ◽  
Author(s):  
Kenneth Gyabaah ◽  
Tamer Aboushwareb ◽  
Nadia Guimaraes Souza ◽  
Liliya Yamaleyeva ◽  
Adam Varner ◽  
...  
Keyword(s):  

2018 ◽  
Author(s):  
Yen-Chung Lin ◽  
Mai-Szu Wu ◽  
Chang-Rong Chen ◽  
Chang-Yu Chen ◽  
Chang-Jui Chen ◽  
...  

The hypothesis being tested Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, and lipotoxicity occurring in kidney can be considered to be a surrogate marker for renal failure or renal fibrosis. Nifedipine-induced lipotoxicity in kidney has never been cited, although a few literature had shown that Nifedipine inhibited lipogenesis via activation of the LKB1-AMPK pathway. Previously, we had recognized in our laboratory some events that seemingly were associated with lipogenesis affected by administration of Nifedipine.


2000 ◽  
Vol 15 (12) ◽  
pp. H2-H2
Author(s):  
IS Mertasudira ◽  
JR Saketi ◽  
A. Djumhana ◽  
J. Widjojo ◽  
SA Abdurachman

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