Chronic renal failure (CRF) is a threat to global health in general and for developing countries in particular. Globally CRF is the 12th highest cause of death. CRF is a progressive loss in renal function taking place over a period of months or years. This initially manifests only as a biochemical abnormality. CRF is considered when glomerular filtration rate (GFR) falls below 30ml/min. The conventional approach of management includes dialysis and renal transplantation, which are not affordable. Therefore, exploration of a safe and alternative therapy is needed. In Ayurveda, the disease can be consider as complication arising from various urinary disorders. A hampering of the function of basti, i.e. urine formation, results in the accumulation of several noxious products in circulation which need excreted management is aimed at eliminating these toxins, to protect the accessible renal cells rejuvenate the quiet cells. In Ayurveda several drugs are used as nephroprotective and this group of drug acts as good non- specific cytoprotectives. In this regard Ayurveda provides leads through its holistic line of management by in co-operative dietary and lifestyle invention and bio-balancing effects of Ayurvedic drugs.