V13-09 HOLMIUM LASER RESECTION OF LARGE BLADDER TUMORS: TECHNIQUE DESCRIPTION, FEASIBILITY, AND HISTOPATHOLOGICAL QUALITY ANALYSIS

Introduction: The thulium laser resection of bladder tumors (TmLRBT) was increasingly used in the treatment of non-muscle-invasive bladder cancer (NMIBC) recently, and here we report the relevant outcomes of our institution to evaluate its efficacy and safety. Methods: We retrospectively collected the data of NMIBC patients who underwent either TmLRBT or transurethral resection of bladder tumor (TURBT). The baseline characteristics and perioperative outcomes were compared in these 2 groups. Results: The TmLRBT had a higher rate of detrusor identification than TURBT (97.4 vs. 87.6%, p = 0.001). After screening, 134 patients who underwent TmLRBT and 152 patients who received TURBT were enrolled in the analysis, and their baseline characteristics were similar. During the TURBT, 24 (15.8%) obturator nerve reflexes and 9 (5.9%) bladder perforations occurred, while none happened during the TmLRBT. After surgery, TmLRBT patients had fewer postoperative gross hematuria (38.1 vs. 96.7%, p < 0.001) and postoperative irrigation (27.6 vs. 92.7%, p < 0.001), and its irrigation duration was significantly shorter (2.3 vs. 3.3 day, p < 0.001). During the follow-up, no significant difference in the recurrence rate was detected (p = 0.315). Conclusions: TmLRBT is a safer technique than conventional TURBT in the treatment of NMIBC, and it could offer better specimens for pathologic assessment while the cancer control was not compromised.

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Observation and mechanism study of bladder wound healing after transurethral holmium laser resection of bladder tumor

Lasers in Medical Science ◽

10.1007/s10103-018-02713-0 ◽

2019 ◽

Vol 34 (6) ◽

pp. 1217-1227

Author(s):

Sha Han ◽

Kai Dong ◽

Mengjun Shen ◽

Xingjie Wang ◽

Wanzi Jiang ◽

...

Keyword(s):

Wound Healing ◽

Bladder Tumor ◽

Holmium Laser ◽

Mechanism Study ◽

Laser Resection

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RE: TRANSURETHRAL HOLMIUM LASER RESECTION OF THE PROSTATE

The Journal of Urology ◽

10.1097/00005392-200010000-00058 ◽

2000 ◽

pp. 1320-1321

Author(s):

K. Matsuoka ◽

S. Iida ◽

K. Tomiyasu ◽

A. Shimada ◽

S. Noda

Keyword(s):

Holmium Laser ◽

Laser Resection

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Randomized controlled trial comparing holmium laser en-bloc resection with monopolar transurethral resection in patients with large bladder tumors

European Urology ◽

10.1016/s0302-2838(21)01242-2 ◽

2021 ◽

Vol 79 ◽

pp. S1216

Author(s):

A. Iscaife ◽

L.A. Ribeiro Filho ◽

M.W. Aparecido Pereira ◽

F. Pescarmona Gallucci ◽

D. Chade ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Transurethral Resection ◽

Controlled Trial ◽

En Bloc Resection ◽

Bloc Resection ◽

Holmium Laser ◽

Bladder Tumors ◽

En Bloc ◽

Randomized Controlled

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Holmium laser resection of the prostate: Preliminary results of a new method for the treatment of benign prostatic hyperplasia

Urology ◽

10.1016/s0090-4295(99)80381-1 ◽

1996 ◽

Vol 47 (1) ◽

pp. 48-51 ◽

Cited By ~ 169

Author(s):

Peter J. Gilling ◽

Carol B. Cass ◽

Michael D. Cresswell ◽

Mark R. Fraundorfer

Keyword(s):

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia ◽

New Method ◽

Holmium Laser ◽

Laser Resection ◽

Preliminary Results

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Bladder paraganglioma managed with transurethral holmium laser resection

Medicine ◽

10.1097/md.0000000000026909 ◽

2021 ◽

Vol 100 (34) ◽

pp. e26909

Author(s):

Xin Zhu ◽

Mi Zhou ◽

Haitao Yu ◽

Youlin Kuang ◽

Yong Chen ◽

...

Keyword(s):

Holmium Laser ◽

Laser Resection

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Thulium Laser Resection of Bladder Tumors vs. Conventional Transurethral Resection of Bladder Tumors for Intermediate and High Risk Non-Muscle-Invasive Bladder Cancer Followed by Intravesical BCG Immunotherapy

Frontiers in Surgery ◽

10.3389/fsurg.2021.759487 ◽

2021 ◽

Vol 8 ◽

Author(s):

Zheng Liu ◽

Gongwei Long ◽

Yucong Zhang ◽

Guoliang Sun ◽

Wei Ouyang ◽

...

Keyword(s):

Transurethral Resection ◽

Cox Regression ◽

Recurrence Risk ◽

Perioperative Outcomes ◽

Thulium Laser ◽

Bladder Tumors ◽

Laser Resection ◽

Bcg Immunotherapy ◽

Intravesical Bcg ◽

Muscle Invasive

Background: Thulium laser resection of bladder tumors (TmLRBT) is recently considered as a common treatment option for non-muscle-invasive bladder cancers (NMIBC), but whether it is superior to Transurethral resection of bladder tumors (TURBT) are still undetermined.Materials and Methods: We retrospectively screened our institution database to identify patients who were treated by conventional TURBT or TmLRBT for NMIBC and followed by intravesical bacillus Calmette-Guérin (BCG) immunotherapy. The preoperative characteristics, perioperative outcomes, and recurrence-free survival were compared to assess the safety and efficacy of the two procedures.Results: Eventually, 90 patients who underwent TmLRBT (n = 37) or TURBT (n = 53) followed by intravesical BCG immunotherapy were included. Two groups were similar in baseline characteristics except for the smaller tumor size of the TmLRBT group(1.7 cm vs. 2.2 cm; P = 0.036). Obturator nerve reflex occurred in eight patients in the TURBT group and 3 of them suffered from bladder perforation while none happened in the TmLRBT group. The TmLRBT also had a shorter irrigation duration. In the multivariate Cox regression, the TmLRBT was related to less recurrence risk (HR: 0.268; 95% CI, 0.095–0.759; P = 0.013).Conclusion: Our results suggested that TmLRBT is safer than conventional TURBT with fewer perioperative complications, and it offers better cancer control, therefore might be a superior option for NMIBC patients with intermediate and high recurrence risk.

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