Clinical Manifestations and Treatment Outcomes of Metastatic Melanoma With Bone Marrow Infiltration

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Venkata R. P. Rokkam ◽  
Gurusaravanan Kutti Sridharan ◽  
Theresa N. Thai ◽  
Akshay Amaraneni ◽  
Srinath Sundararajan
Keyword(s):  
Bone Marrow ◽  
Treatment Outcomes ◽  
Metastatic Melanoma ◽  
Clinical Manifestations ◽  
Bone Marrow Infiltration

scholarly journals A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms

Children ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 509
Author(s):  
Lydia Kossiva ◽  
Athanasios Thirios ◽  
Eleni Panagouli ◽  
Alexandros Panos ◽  
Stavroula Lampidi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Viral Infection ◽  
Nasal Congestion ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Bone Marrow Aspiration ◽  
White Blood Count ◽  
Chronic Obstructive ◽  
First Case ◽  
The Impact

Since the beginning of the COVID-19 pandemic, there have been numerous reports and reviews on the complications caused by the disease, analyzing the acute and chronic consequences. The main symptoms of SARS-CoV-2 are dry cough, fever, and fatigue. COVID-19 appears to affect all systems, including renal, cardiovascular, circulatory, and respiratory systems, causing chronic obstructive pulmonary disease. We report on a 14-year-old male adolescent, who presented with thrombocytopenia (platelet count 92 × 109 /L) and leukopenia (white blood count 4.2 × 103 /μL) that was observed two months ago. Ten days before the first blood test, a viral infection with nasal congestion and runny nose was reported, without other accompanying symptoms. Viral antibodies screening revealed positivity for all the three specific COVID-19 antibodies. Further haematological evaluation with bone marrow aspiration revealed non-specific dysplastic features of the red cell and megakaryocyte progenitors. Although haematological alterations due to COVID-19 infection are available from adult patients’ reports, the effect of COVID-19 infection in the pediatric population is underestimated and this is the first case with such haematological involvement. Noteworthy, in the current case, the impact of the COVID-19 infection was not related to the severity of the disease, as the symptoms were mild. In similar cases, bone marrow aspiration would not be performed as a part of routine work-up. Thus, it is important when evaluating pediatric patients with COVID-19 infection to search and report those alterations in order to better understand the impact and the spectrum of clinical manifestations of the specific viral infection in children and adolescents.

scholarly journals Conditioning with Fludarabine-Busulfan versus Busulfan-Cyclophosphamide Is Associated with Lower aGVHD and Higher Survival but More Extensive and Long Standing Bone Marrow Damage

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Xin He ◽  
YongBin Ye ◽  
XiaoJun Xu ◽  
Jing Wang ◽  
YuXian Huang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Conditioning Regimen ◽  
Clinical Manifestations ◽  
Major Complication ◽  
Clinical Situation ◽  
Hematopoietic Stem ◽  
T Cell Infiltration ◽  
Bone Marrow Damage ◽  
The Impact

Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a major cause of nonrelapse mortality after allo-HSCT. A conditioning regimen plays a pivotal role in the development of aGVHD. To provide a platform for studying aGVHD and evaluating the impact of different conditioning regimens, we established a murine aGVHD model that simulates the clinical situation and can be conditioned with Busulfan-Cyclophosphamide (Bu-Cy) and Fludarabine-Busulfan (Flu-Bu). In our study, BALB/c mice were conditioned with Bu-Cy or Flu-Bu and transplanted with 2×107 bone marrow cells and 2×107 splenocytes from either allogeneic (C57BL/6) or syngeneic (BALB/c) donors. The allogeneic recipients conditioned with Bu-Cy had shorter survivals (P<0.05), more severe clinical manifestations, and higher hepatic and intestinal pathology scores, associated with increased INF-γ expression and diminished IL-4 expression in serum, compared to allogeneic recipients conditioned with Flu-Bu. Moreover, higher donor-derived T-cell infiltration and severely impaired B-cell development were seen in the bone marrow of mice, exhibiting aGVHD and conditioned with Flu-Bu. Our study showed that the conditioning regimen with Bu-Cy resulted in more severe aGVHD while the Flu-Bu regimen was associated with more extensive and long standing bone marrow damage.

scholarly journals Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children

2015 ◽  
Vol 18 (4) ◽  
pp. 253 ◽  
Author(s):  
Jong Sub Choi ◽  
Shin Jie Choi ◽  
Kyung Jae Lee ◽  
Ahlee Kim ◽  
Jung Kyung Yoo ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Clinical Manifestations ◽  
Eosinophilic Gastroenteritis

No Correlation of Tyrosinase mRNA in Bone Marrow with Prognosis of Metastatic Melanoma

Dermatology ◽  
2000 ◽  
Vol 201 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Volker Waldmann ◽  
Jörg Wacker ◽  
Martin Deichmann ◽  
Helmut Näher
Keyword(s):  
Bone Marrow ◽  
Metastatic Melanoma

scholarly journals The Correlations between Clinical Features, Dermoscopic and Histopathological Findings, and Treatment Outcomes of Patients with Pitted Keratolysis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Penvadee Pattanaprichakul ◽  
Kanokvalai Kulthanan ◽  
Sumanas Bunyaratavej ◽  
Sasima Eimpunth ◽  
Thanaporn Rungruang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Informed Consent ◽  
Bacterial Infection ◽  
Treatment Outcomes ◽  
Clinical Manifestations ◽  
Current Data ◽  
Histopathological Finding ◽  
Histopathological Findings ◽  
Naked Eye ◽  
Color Alteration

Background. Pitted keratolysis (PK) is a superficial bacterial infection diagnosed mainly by clinical manifestations. Current data on its dermoscopic and histopathological findings, and the correlation of those findings, are limited. Objectives. To evaluate the clinical manifestations, dermoscopic, and histopathological findings of PK and to determine the correlations. Methods. Forty naval cadets with PK and five cadets with normal feet were enrolled this cohort study and provided informed consent. Dermoscopy was independently applied and evaluated by 2 dermatologists. Shave biopsies were performed on 37 patients with PK. Results. Pits were the most common dermoscopic finding (88.1%). The dermoscope had more sensitivity for the detection of PK than the naked eye examinations. Apart from the pits and the presence of bacteria, the most common histopathological finding for PK was color alteration of keratin. The presence of bacteria correlated with interrupted dermatoglyphic lines and the color alteration of keratin. Moreover, the presence of bacteria at the base of pits was related to worse treatment outcomes. Conclusions. Dermoscopy is a useful tool for PK diagnosis. Color alteration of keratin is another histopathological finding for PK. The presence of bacteria is associated with worse treatment outcomes.

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