scholarly journals A Case of COVID-19-Related Thrombocytopenia and Leukopenia in an Adolescent with Mild Symptoms

Children ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 509
Author(s):  
Lydia Kossiva ◽  
Athanasios Thirios ◽  
Eleni Panagouli ◽  
Alexandros Panos ◽  
Stavroula Lampidi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Viral Infection ◽  
Nasal Congestion ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Bone Marrow Aspiration ◽  
White Blood Count ◽  
Chronic Obstructive ◽  
First Case ◽  
The Impact

Since the beginning of the COVID-19 pandemic, there have been numerous reports and reviews on the complications caused by the disease, analyzing the acute and chronic consequences. The main symptoms of SARS-CoV-2 are dry cough, fever, and fatigue. COVID-19 appears to affect all systems, including renal, cardiovascular, circulatory, and respiratory systems, causing chronic obstructive pulmonary disease. We report on a 14-year-old male adolescent, who presented with thrombocytopenia (platelet count 92 × 109 /L) and leukopenia (white blood count 4.2 × 103 /μL) that was observed two months ago. Ten days before the first blood test, a viral infection with nasal congestion and runny nose was reported, without other accompanying symptoms. Viral antibodies screening revealed positivity for all the three specific COVID-19 antibodies. Further haematological evaluation with bone marrow aspiration revealed non-specific dysplastic features of the red cell and megakaryocyte progenitors. Although haematological alterations due to COVID-19 infection are available from adult patients’ reports, the effect of COVID-19 infection in the pediatric population is underestimated and this is the first case with such haematological involvement. Noteworthy, in the current case, the impact of the COVID-19 infection was not related to the severity of the disease, as the symptoms were mild. In similar cases, bone marrow aspiration would not be performed as a part of routine work-up. Thus, it is important when evaluating pediatric patients with COVID-19 infection to search and report those alterations in order to better understand the impact and the spectrum of clinical manifestations of the specific viral infection in children and adolescents.

scholarly journals Conditioning with Fludarabine-Busulfan versus Busulfan-Cyclophosphamide Is Associated with Lower aGVHD and Higher Survival but More Extensive and Long Standing Bone Marrow Damage

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Xin He ◽  
YongBin Ye ◽  
XiaoJun Xu ◽  
Jing Wang ◽  
YuXian Huang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Conditioning Regimen ◽  
Clinical Manifestations ◽  
Major Complication ◽  
Clinical Situation ◽  
Hematopoietic Stem ◽  
T Cell Infiltration ◽  
Bone Marrow Damage ◽  
The Impact

Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a major cause of nonrelapse mortality after allo-HSCT. A conditioning regimen plays a pivotal role in the development of aGVHD. To provide a platform for studying aGVHD and evaluating the impact of different conditioning regimens, we established a murine aGVHD model that simulates the clinical situation and can be conditioned with Busulfan-Cyclophosphamide (Bu-Cy) and Fludarabine-Busulfan (Flu-Bu). In our study, BALB/c mice were conditioned with Bu-Cy or Flu-Bu and transplanted with 2×107 bone marrow cells and 2×107 splenocytes from either allogeneic (C57BL/6) or syngeneic (BALB/c) donors. The allogeneic recipients conditioned with Bu-Cy had shorter survivals (P<0.05), more severe clinical manifestations, and higher hepatic and intestinal pathology scores, associated with increased INF-γ expression and diminished IL-4 expression in serum, compared to allogeneic recipients conditioned with Flu-Bu. Moreover, higher donor-derived T-cell infiltration and severely impaired B-cell development were seen in the bone marrow of mice, exhibiting aGVHD and conditioned with Flu-Bu. Our study showed that the conditioning regimen with Bu-Cy resulted in more severe aGVHD while the Flu-Bu regimen was associated with more extensive and long standing bone marrow damage.

scholarly journals Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Samin Alavi ◽  
Maryam Ebadi ◽  
Alireza Jenabzadeh ◽  
M. T. Arzanian ◽  
Sh. Shamsian
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Chromosomal Abnormalities ◽  
Bone Marrow Aspiration ◽  
Review Of The Literature ◽  
Monosomy 7 ◽  
Persistent Fever ◽  
First Case ◽  
Erythroid Precursors

Herein, the first case of childhood erythrophagocytosis following chemotherapy for erythroleukemia in a child with monosomy 7 is reported. A 5-year-old boy presented with anemia, thrombocytopenia, and hepatosplenomegaly in whom erythroleukemia was diagnosed. Prolonged pancytopenia accompanied by persistent fever and huge splenomegaly and hepatomegaly became evident after 2 courses of chemotherapy. On bone marrow aspiration, macrophages phagocytosing erythroid precursors were observed and the diagnosis of HLH was established; additionally, monosomy 7 was detected on bone marrow cytogenetic examination. In conclusion, monosomy 7 can lead to erythrophagocytosis associated with erythroid leukemia and should be considered among the chromosomal abnormalities contributing to the association.

Management of vasomotor rhinitis patients

2020 ◽  
pp. 24-28
Author(s):  
Konstantin Robertovich Gulyabin
Keyword(s):  
Viral Infection ◽  
Nasal Congestion ◽  
Clinical Manifestations ◽  
Posterior Pharyngeal Wall ◽  
Respiratory Obstruction ◽  
Vasomotor Rhinitis ◽  
Respiratory Viral Infection ◽  
Pharyngeal Wall ◽  
Chronic Rhinitis ◽  
The Subject

There has been a recent obvious trend towards the increased prevalence of chronic rhinitis – 10-20% of the population experiences this disorder. Vasomotor rhinitis, sometimes also called idiopathic rhinitis, is the indisputable leader among various chronic rhinitis forms (allergic, infectious, atrophic, catarrhal and hypertrophic). The term of vasomotor rhinitis has been the subject of experts' repeated criticism because neurovisceral innervation disorders that underlie this condition are found in almost every form of chronic rhinitis. The main clinical manifestations of vasomotor rhinitis include a feeling of nasal congestion and nasal respiratory obstruction, regular abundant discharge of clear mucus and a feeling of its trickling down the posterior pharyngeal wall. A past respiratory viral infection treated by excessive quantities of vasoconstrictor drops triggers the vasomotor rhinitis onset in most cases.

scholarly journals A novel diagnostic model based on differences in clinical characteristics of influenza A and B

2021 ◽  
Author(s):  
Xiang WeiPeng ◽  
Che Li ◽  
Zhang Miao ◽  
Gao WuTong ◽  
Tian Tian ◽  
...  
Keyword(s):  
Influenza A ◽  
Clinical Characteristics ◽  
Nasal Congestion ◽  
Clinical Manifestations ◽  
Influenza B ◽  
Diagnostic Model ◽  
Lasso Regression ◽  
Laboratory Findings ◽  
Runny Nose ◽  
The Impact

The aim of this study is to construct a clinical distinction model to help determine the type of influenza by analyzing the clinical characteristics and hematological indicators of influenza patients during the influenza season. Demographic characteristics and clinical data of 726 influenza patients aged 7 years and older from September 2018 to July 2019 were collected, and logistic regression analysis was used to analyze the impact of different clinical manifestations and hematological examination indicators on the determination of the value of the flu type. The common clinical manifestations of influenza patients were fever (99.2%), pharyngeal congestion (97.1%), cough (80.4%), sore throat (57.2%), muscle aches (48.8%), and runny nose (45.2%). Those with onset of illness were 19-49 years of age (OR= 0.335, 95% CI: 0.196-0.573), nasal congestion (OR= 0.566, 95% CI: 0.349-0.919), and fever for more than 3 days (OR= 0.368, 95% CI: 0.214-0.632) tend to diagnosed as influenza B, while those with symptoms of cough (OR=2.119, 95% CI: 1.322-3.389), headache (OR=1.834, 95% CI: 1.157-2.908), muscle pain (OR=1.811, 95% CI: 1.139-2.880), and blood CPR>8mg/L (OR=2.315, 95%CI: 1.501-3.589) and the percentage of neutrophils >70% (OR=2.361, 95%CI: 1.171-4.759) are prone to have influenza A. Combining clinical manifestations and laboratory findings, we plotted a nomogram by lasso regression. The distinction model was discriminated using a C-index（0.765,95% CI 0.716-0.819) and an AUC value (0.772,95% CI 0.696-0.848), showing good prognostic accuracy and clinical applicability. This distinction model can distinguish well between the types of influenza,which can provide assistance in early treatment and prognosis of influenza.

scholarly journals Busulfan-Cyclophosphamide Worsens Peripheral Gvhd While Fludarabine-Busulfan Results in Wide Bone Marrow Involvement in a Murine Model of Acute Gvhd

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5791-5791
Author(s):  
Xin He ◽  
Xiaojun Xu ◽  
Yongbin Ye ◽  
Qifa Liu
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Conflicts Of Interest ◽  
Bone Marrow Involvement ◽  
Conditioning Regimen ◽  
Clinical Manifestations ◽  
Major Complication ◽  
Clinical Situation ◽  
Hematopoietic Stem ◽  
The Impact

Abstract Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and A proper conditioning regimen is vital to stop the development of aGVHD. To provide a platform for the study of aGVHD and evaluate the impact of different conditioning regimens, we established a murine aGVHD model that simulates the clinical situation and can be conditioned with Busulfan-Cyclophosphamide (BU-Cy) and Fludarabine-BU (Flu-BU). In our study, BALB/c mice were conditioned with BU-Cy or Flu-BU and transplanted with 2×107 bone marrow cells and 2×107splenocytes from either allogeneic (C57BL/6) or syngeneic (BALB/c) donors. The allogeneic recipients conditioned with BU-Cy had shorter survival (P<0.05) and more severe hepatic and intestinal clinical manifestations and pathological changes associated with increased INF-γ expression and diminished IL-4 expression in serum compared to allogeneic recipients conditioned with Flu-BU. Meanwhile increased donor-derived T-cell infiltration and impaired bone marrow B-cell development could be seen in the aGVHD mice conditioned with Flu-BU. Our study showed that the conditioning regimen with BU-Cy resulted in more severe peripheral aGVHD, while the Flu-BU regimen was associated with aGVHD with wide bone marrow involvement. Disclosures No relevant conflicts of interest to declare.

Clinical and Infective Outcome of Parasitologicaly Confirmed Kala-Azar Patients Treated with Sodium Antimony Gluconate

1970 ◽  
Vol 11 (1) ◽  
pp. 12-16
Author(s):  
Quazi Tarikul Islam ◽  
Ahasan Habib ◽  
Azizul Haque Azad ◽  
HAM Nazmul Ahasan ◽  
Md Mahmudur Rahman Siddiqui ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Leishmania Donovani ◽  
Clinical Manifestations ◽  
Bone Marrow Aspiration ◽  
Sand Fly ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Kala Azar ◽  
Sodium Antimony Gluconate

A total of fifty consecutive cases of Kala-azar admitted in the medicine units of Rajshahi Medical College Hospital during the period from February 2006 to October 2006 were included in this study. The number of the patients clearly indicates that the burden of Kala-azar in this region is significant and expanding. Male to female ratio was 1.9:1. Fever (96%) and splenomegaly (100%) were the predominant features. Hepatomegaly was found in 82% of the cases. Other clinical manifestations were Hyperpigmentation (76%), weight loss (62%), pallor (60%), jaundice (10%), oedema (10%), cough (6%) and lymphadenopathy (4%). Fever of 75% cases subsided within one week of starting treatment. Weight of 89.6% cases increased after completion of treatment. After completion of treatment spleen size regressed in 95.8% cases and no LD (Leishmania donovani) body was seen in 46 (92%) patients splenic / bone marrow aspiration after completion of treatment. 2 (4%) patients remain LD body positive after completion of treatment and 2 (4%) patients died during treatment. Still sodium antimony gluconate (SAG) is very effective in the clinical and parasitologicaly confirmed Kala-azar patients. A combination of sand fly control, early detection and treatment of the patients is the best approach for controlling Kala-azar. Keyword: Kala-azar, Sodium Stibogluconate, LD (Leishmania donovani) body, splenic or bone marrow aspiration. DOI:10.3329/jom.v11i1.4261 J Medicine 2010: 11: 12-16

scholarly journals A novel diagnostic model based on differences in clinical characteristics of influenza A and B

2021 ◽  
Author(s):  
Xiang WeiPeng ◽  
Che Li ◽  
Zhang Miao ◽  
Gao WuTong ◽  
Tian Tian ◽  
...  
Keyword(s):  
Influenza A ◽  
Clinical Characteristics ◽  
Nasal Congestion ◽  
Clinical Manifestations ◽  
Influenza B ◽  
Diagnostic Model ◽  
Lasso Regression ◽  
Laboratory Findings ◽  
Runny Nose ◽  
The Impact

The aim of this study is to construct a clinical distinction model to help determine the type of influenza by analyzing the clinical characteristics and hematological indicators of influenza patients during the influenza season. Demographic characteristics and clinical data of 726 influenza patients aged 7 years and older from September 2018 to July 2019 were collected, and logistic regression analysis was used to analyze the impact of different clinical manifestations and hematological examination indicators on the determination of the value of the flu type. The common clinical manifestations of influenza patients were fever (99.2%), pharyngeal congestion (97.1%), cough (80.4%), sore throat (57.2%), muscle aches (48.8%), and runny nose (45.2%). Those with onset of illness were 19-49 years of age (OR= 0.335, 95% CI: 0.196-0.573), nasal congestion (OR= 0.566, 95% CI: 0.349-0.919), and fever for more than 3 days (OR= 0.368, 95% CI: 0.214-0.632) tend to diagnosed as influenza B, while those with symptoms of cough (OR=2.119, 95% CI: 1.322-3.389), headache (OR=1.834, 95% CI: 1.157-2.908), muscle pain (OR=1.811, 95% CI: 1.139-2.880), and blood CPR>8mg/L (OR=2.315, 95%CI: 1.501-3.589) and the percentage of neutrophils >70% (OR=2.361, 95%CI: 1.171-4.759) are prone to have influenza A. Combining clinical manifestations and laboratory findings, we plotted a nomogram by lasso regression. The distinction model was discriminated using a C-index（0.765,95% CI 0.716-0.819) and an AUC value (0.772,95% CI 0.696-0.848), showing good prognostic accuracy and clinical applicability. This distinction model can distinguish well between the types of influenza,which can provide assistance in early treatment and prognosis of influenza.

scholarly journals Patellar Osteomyelitis in a 9-Year-Old Patient with Chronic Granulomatous Disease: A Case Report

Children ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 76
Author(s):  
Yonggeun Park ◽  
Seungjin Yoo ◽  
Yongyeon Chu ◽  
Chaemoon Lim
Keyword(s):  
Chronic Granulomatous Disease ◽  
Fungal Infections ◽  
Pediatric Population ◽  
Clinical Manifestations ◽  
Granulomatous Disease ◽  
Advanced Imaging ◽  
Hematogenous Osteomyelitis ◽  
First Case ◽  
Acute Hematogenous Osteomyelitis ◽  
High Index Of Suspicion

Hematogenous osteomyelitis is commonly reported in long tubular bones in the pediatric population. Acute osteomyelitis involving the patella is extremely uncommon in children, and its diagnosis is frequently delayed due to its rarity and variable clinical manifestations. Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency disorder characterized by severe recurrent bacterial and fungal infections. The most commonly affected sites of infection are the lungs, lymph nodes, skin, liver, and gastrointestinal tract. Acute hematogenous osteomyelitis of the patella associated with CGD has never been reported. Our report describes the first case of acute hematogenous patellar osteomyelitis in a pediatric patient with CGD. Her clinical manifestations were similar to other possible differentials such as septic arthritis; however, use of advanced imaging confirmed the diagnosis, and the patient was successfully managed surgically. Since hematogenous osteomyelitis in children is uncommon, a high index of suspicion and advanced imaging may help with its diagnosis, and in cases where antibiotic treatment proves to be insufficient, prompt surgical management is imperative.

scholarly journals Eosinophilic inflammation in chronic obstructive pulmonary disease

2019 ◽  
Vol 91 (10) ◽  
pp. 144-152
Author(s):  
S N Avdeev ◽  
N V Trushenko ◽  
Z M Merzhoeva ◽  
M S Ivanova ◽  
E V Kusraeva
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Targeted Therapy ◽  
Pulmonary Disease ◽  
Clinical Manifestations ◽  
Chronic Obstructive ◽  
Eosinophilic Inflammation ◽  
Obstructive Pulmonary Disease ◽  
Pathophysiological Mechanisms ◽  
The Impact

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that combines various clinical manifestations and pathophysiological mechanisms. It underlies the separation of patients with COPD by phenotypes, endotypes and a personalized therapy of this disease. The implementation of this approach is possible only with the use of appropriate biomarkers. One of the most important biomarkers of COPD is eosinophilia of blood and/or sputum, which is considered as a predictor of frequent exacerbations and the effectiveness of inhaled glucocorticosteroids in patients with COPD. The literature discusses the impact of eosinophilic inflammation on the prognosis, clinical and functional parameters in COPD, and the role of the targeted therapy in the treatment of eosinophilic COPD.

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