Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children

Background. Pitted keratolysis (PK) is a superficial bacterial infection diagnosed mainly by clinical manifestations. Current data on its dermoscopic and histopathological findings, and the correlation of those findings, are limited. Objectives. To evaluate the clinical manifestations, dermoscopic, and histopathological findings of PK and to determine the correlations. Methods. Forty naval cadets with PK and five cadets with normal feet were enrolled this cohort study and provided informed consent. Dermoscopy was independently applied and evaluated by 2 dermatologists. Shave biopsies were performed on 37 patients with PK. Results. Pits were the most common dermoscopic finding (88.1%). The dermoscope had more sensitivity for the detection of PK than the naked eye examinations. Apart from the pits and the presence of bacteria, the most common histopathological finding for PK was color alteration of keratin. The presence of bacteria correlated with interrupted dermatoglyphic lines and the color alteration of keratin. Moreover, the presence of bacteria at the base of pits was related to worse treatment outcomes. Conclusions. Dermoscopy is a useful tool for PK diagnosis. Color alteration of keratin is another histopathological finding for PK. The presence of bacteria is associated with worse treatment outcomes.

Download Full-text

Clinical Manifestations and Treatment Outcomes of Metastatic Melanoma With Bone Marrow Infiltration

American Journal of Therapeutics ◽

10.1097/mjt.0000000000001384 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Venkata R. P. Rokkam ◽

Gurusaravanan Kutti Sridharan ◽

Theresa N. Thai ◽

Akshay Amaraneni ◽

Srinath Sundararajan

Keyword(s):

Bone Marrow ◽

Treatment Outcomes ◽

Metastatic Melanoma ◽

Clinical Manifestations ◽

Bone Marrow Infiltration

Download Full-text

Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population

Journal of Ophthalmology ◽

10.1155/2016/2797028 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Rui Zhang ◽

Jiang Qian ◽

Jie Guo ◽

Yifei Yuan ◽

Kang Xue ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Treatment Outcomes ◽

Chinese Population ◽

Retinal Vasculitis ◽

Clinical Manifestations ◽

Case Series ◽

Posterior Uveitis ◽

Retrospective Case ◽

Serological Tests ◽

Immunodeficiency Virus

Purpose. To describe the clinical manifestations and treatment outcomes of syphilitic uveitis in a Chinese population.Methods. This is a retrospective case series of 15 consecutive patients with syphilitic uveitis treated at a uveitis referral center between 2012 and 2015.Results. Fifteen patients were diagnosed with syphilitic uveitis based on positive serological tests. Nine patients were male. Coinfection with human immunodeficiency virus was detected in two patients. Twenty eyes presented with panuveitis and all patients had posterior involvement. The most frequent manifestations were retinal vasculitis and papillitis, while syphilitic posterior placoid chorioretinitis was only found in three eyes. All patients received systemic penicillin therapy according to CDC guidelines. Nine patients were misdiagnosed before presenting to our center and the delay in treatment with penicillin was associated with poor final visual outcomes (P<0.05).Conclusions. In our series, both male and female were almost equally affected and coinfection of syphilis with human immunodeficiency virus was uncommon. All patients in this study had posterior involvement and the most common manifestations were retinal vasculitis and papillitis. Syphilis should be considered as an important differential diagnosis especially for posterior uveitis and panuveitis. Early diagnosis and appropriate treatment are important for visual prognosis.

Download Full-text

Epidemiology of tuberculosis and treatment outcomes among children in Pakistan: a 5 year retrospective study

PeerJ ◽

10.7717/peerj.5253 ◽

2018 ◽

Vol 6 ◽

pp. e5253 ◽

Cited By ~ 4

Author(s):

Madeeha Laghari ◽

Syed Azhar Syed Sulaiman ◽

Amer Hayat Khan ◽

Naheed Memon

Keyword(s):

Retrospective Study ◽

Treatment Outcomes ◽

Urban Areas ◽

Demographic Data ◽

Treatment Success ◽

Clinical Manifestations ◽

Sputum Smear ◽

Unsuccessful Treatment ◽

Patients At Risk ◽

Group 2

Background Regardless of the advancement in medical technologies, the diagnosis of tuberculosis (TB) in children has remained a challenge. Childhood TB is rampant and an important cause of morbidity and mortality. The objective of this study was to determine the trend of TB and treatment outcomes in children aged ≤14 years registered for TB treatment under DOTS course in three districts of Sindh, Pakistan. Methods For this retrospective study, records of TB children (≤14 years) registered for the treatment of TB from January 2011 to December 2015 in three districts of Pakistan, were collected. Demographic data, baseline weight, clinical manifestations, radiography, histopathology results and treatment outcomes were collected from TB unit registers. Results A total of 2,167 children were treated for TB during the study period. Of these, 1,199 (55.3%) were females and 1,242 (57.3%) were from urban areas. Over three-quarter of patients (76.9%) had pulmonary TB with 13.3% of sputum smear positive cases. The overall treatment success rate was 92.4%. In multivariate analysis, rural residents (OR: 2.146, p < 0.001), sputum smear positive cases (OR: 3.409, p < 0.001) and re-treated patients (OR: 5.919, p < 0.001), were significantly associated with unsuccessful treatment outcomes. However, age group ≤2 years, male and those who were underweight were found to have the highest risk of pulmonary tuberculosis (OR: 1.953, p < 0.001; OR: 1.262, p = 0.028; OR: 1.342, p = 0.008), respectively. Conclusion Patients at risk of treatment failure must be given particular attention. Moreover, strategies are needed to further improve the diagnosis and treatment of TB among children and improve the recording system.

Download Full-text

Clinical Manifestations and Treatment Outcomes of Pyoderma Gangrenosum on Rituximab Therapy: A Systematic Review

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2021.12.028 ◽

2021 ◽

Author(s):

David Croitoru ◽

Nikki Nathanielsz ◽

Kyle Seigel ◽

Rawaan Elsawi ◽

Cathryn Sibbald ◽

...

Keyword(s):

Systematic Review ◽

Treatment Outcomes ◽

Pyoderma Gangrenosum ◽

Clinical Manifestations

Download Full-text

A retrospective study on Tuberculous Lymphadenitis; A retrospective finding from multicenters referal hospitals

10.21203/rs.3.rs-15640/v1 ◽

2020 ◽

Author(s):

Syed Ghouse Mohiuddin ◽

Siti Maisharah ◽

Orwa Albitar ◽

Muhammad Shahid Iqbal ◽

Amer Hayat Khan

Keyword(s):

Retrospective Study ◽

Treatment Outcomes ◽

Univariate Analysis ◽

Clinical Manifestations ◽

P Value ◽

Tuberculous Lymphadenitis ◽

Age Group ◽

Early Management ◽

Unsuccessful Treatment ◽

Multiple Variables

Abstract Background Extra-pulmonary tuberculosis (EPTB) represents about 14% of all cases of tuberculosis (TB) in Malaysia. The aims of the study include evaluation of socio-demographic factors, clinical manifestations, co-morbidities among patients with Tuberculous Lymphadenitis and their treatment outcomes.Methods The retrospective study was conducted from 2006 to 2008. Data on socio-demographic along with histopathological results were collected. Signs and symptoms were also recorded from TB registers, treatment cards and TB medical personal files using standard data collection tool. Among multiple variables significant factors identified by univariate analysis, were included in multivariate logistic regression to estimate the odds ratios (ORs) with the 95% confidence intervals (CIs). The statistically significant p value was considered as < 0.05.Results There were 348 (57%) males and on the other hand 262 (43%) females which shows almost equal incidence rate of Lymphadenitis in both genders. Mean age was found as 34.3 ± 14.6 years were majorly reported with positive diagnosis. 196 (32.1%) Malay was found with Tuberculous lymphadenitis followed by Chinese population of 148 (24.3%). Geographically from 386 (63.3%) urban population were found positive for lymphadenitis and over 224 (36.7%) of rural region. treatment outcome was observed 444 (72.8%) with successful treatment. WHO states the types of treatment failures and accordingly 85 (13.9%) patients were continued with the therapy that can be due to non-compliance or relapse of Tb. Among unsuccessful outcomes 194 patients of age group 26 -35 years, 65 (33.5%) were reported and 38 (29.7%) patients out of 128 between 16 – 25 years. Blood results showed erythrocyte sedimentation rate greater than 10 in 280 (45.9%) patients. Therefore, among 280 there were 115 (41.1%) patients found to have unsuccessful treatment showing strong association with p-value of <0.001.Conclusion Finding signifies that effect of weight loss on poor treatment outcomes` and active screening measures for patients with comorbidities are therefore recommended in patients with Tb lymphadenitis along with improvements in the diagnosis and early management of co-morbidities complications. As young age group were found to have poor or unsuccessful treatment outcomes and required aggressive strategy together with educating patients can further increase the treatment success rate.

Download Full-text