Lesion detection in 18F-sodium fluoride bone imaging

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Natalie Anne Bebbington ◽  
Helle Damgaard Zacho ◽  
Paw Christian Holdgaard
Keyword(s):  
Sodium Fluoride ◽  
Lesion Detection ◽  
Bone Imaging

18F-labeled bisphosphonate as an alternative candidate to the gold standard [18F]sodium fluoride ([18F]NaF) for PET bone imaging

2021 ◽  
Vol 17 ◽  
Author(s):  
Hishar Hassan ◽  
Muhammad Faiz Othman ◽  
Hairil Rashmizal Abdul Razak
Keyword(s):  
Bone Metastases ◽  
Sodium Fluoride ◽  
Drug Targets ◽  
Bone Cancer ◽  
Common Source ◽  
Bone Imaging ◽  
Positron Emission ◽  
Early Markers ◽  
Primary Bone ◽  
Novel Drug

: Bone metastases are a common source of malignancy in the skeleton and occur much more often than primary bone cancer. Several works were ongoing to identify early markers for bone metastasis and novel drug targets to improve patients' quality of life. As some concerns exist with the [18F]sodium fluoride in positron emission tomography (PET) bone imaging, there has been an increase in the number of targeted radiopharmaceutical markers for bone metastases imaging in its competitor, 68Ga. Since 18F properties are superior to those of 68Ga, there is a distinct motivation for developing 18F radiopharmaceuticals for bone metastases imaging.

scholarly journals Optimization of radiation exposure in18F-sodium fluoride positron emission tomography-computed tomography in bone imaging: Quo vadis

2019 ◽  
Vol 34 (2) ◽  
pp. 157
Author(s):  
Rashid Rasheed ◽  
Sharjeel Usmani ◽  
SyedAli Raza Naqvi ◽  
Fareeda Alkandari ◽  
FahadA Marafi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Radiation Exposure ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Bone Imaging ◽  
Positron Emission ◽  
Quo Vadis

scholarly journals [18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tomography ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 843-854
Author(s):  
Tanuj Puri ◽  
Michelle L. Frost ◽  
Gary J. Cook ◽  
Glen M. Blake
Keyword(s):  
Kinetic Parameters ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Imaging Biomarker ◽  
Bone Imaging ◽  
Positron Emission ◽  
Novel Drugs ◽  
Early Phase Clinical Trials ◽  
Pet Scans ◽  
Bone Physiology

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

scholarly journals Bone Imaging with F-18 Sodium Fluoride Positron Emission Tomography

RADIOISOTOPES ◽  
2009 ◽  
Vol 58 (9) ◽  
pp. 629-635
Author(s):  
Masashi KAWAGUCHI ◽  
Kazuya SHIZUKUISHI ◽  
Tomio INOUE
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Bone Imaging ◽  
Positron Emission

Kinetics and mechanism of the reduction of selenium (IV) by iron (II) in presence of sodium fluoride

1973 ◽  
Vol 70 ◽  
pp. 918-922 ◽  
Author(s):  
R. K. Srivastava ◽  
V. K. Srivastava ◽  
M. N. Srivastava ◽  
B. B. L. Saxena
Keyword(s):  
Sodium Fluoride ◽  
Kinetics And Mechanism

18F-sodium fluoride bone deposition quantitation with PET in Mice: Variation with age, sex, and circadian rhythm

2020 ◽  
Vol 59 (06) ◽  
pp. 428-437
Author(s):  
Viktoria Dorau-Rutke ◽  
Kai Huang ◽  
Mathias Lukas ◽  
Marc O. Schulze ◽  
Christian Rosner ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Sodium Fluoride ◽  
Bone Growth ◽  
Bone Volume ◽  
Sleep Phase ◽  
Median Percentage ◽  
Bone Uptake ◽  
Pooled Data ◽  
Uptake Studies ◽  
Bone Deposition

Abstract Aim The aim of this study was to establish a data base for normal 18F-sodium fluoride (18F-NaF) bone uptake as a function of age, sex and circadian rhythm in mice. Methods In 12 female (F) and 12 male (M) C57BL/6N mice PET images were acquired 90 min after intravenous injection of 20 MBq 18F-NaF for 30 minutes. Each mouse was imaged in follow-up studies at 1, 3, 6, 13 and 21 months of age. In order to assess for physiologic changes related to circadian rhythm, animals were imaged during light (sleep phase) as well as during night conditions (awake phase). Bone uptake is described as the median percentage of the injected activity (%IA) and in relation to bone volume (%IA/ml). Results A significant smaller bone volume was found in F (1.79 ml) compared to M (1.99 ml; p < 0.001). In sex-pooled data, highest bone uptake occurred at an age of 1 month (61.1 %IA, 44.5 %IA/ml) with a significant reduction (p < 0.001) at age 3 months (43.6 %IA, 23.6 %IA/ml), followed by an increase between 13 (47.3 %IA, 24.5 %IA/ml) and 21 months (52.2 %IA, 28.1 %IA/ml). F had a significantly higher total uptake (F 48.2 %IA, M 43.8 %IA; p = 0.026) as well as a higher uptake per ml bone tissue (F 27.0 %IA/ml; M 22.4 %IA/ml; p < 0.001). A significant impact of circadian rhythm was only found for F at ages of 3 and 6 months with a higher uptake during the sleep phase. Conclusion Circadian rhythm had a significant impact on uptake only in F of 3 and 6 months. Regarding sex, F showed generally higher uptake rates than M. The highest uptake values were observed during bone growth at age 1 month in both sexes, a second uptake peak occurred in elderly F. Designing future bone uptake studies with M, attention must be paid to age only, while in F circadian rhythm and age must be taken into account.

F-18-FDG Positron Imaging in Oncological Patients: Gamma Camera Coincidence Detection versus Dedicated PET

1999 ◽  
Vol 38 (04) ◽  
pp. 108-114 ◽  
Author(s):  
H.-J. Kaiser ◽  
U. Cremerius ◽  
O. Sabri ◽  
M. Schreckenberger ◽  
P. Reinartz ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Spatial Resolution ◽  
Gamma Camera ◽  
Lesion Detection ◽  
Coincidence Detection ◽  
System Sensitivity ◽  
Oncological Patients ◽  
Phantom Studies ◽  
Pet System ◽  
Dedicated Pet

Summary Aim of the present study was to investigate the feasibility of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) imaging in oncological patients with a dual head gamma camera modified for coincidence detection (MCD). Methods: Phantom studies were done to determine lesion detection at various lesion-to-background ratios, system sensitivity and spatial resolution. Thirty-two patients with suspected or known malignant disease were first studied with a dedicated full-ring PET system (DPET) applying measured attenuation correction and subsequently with an MCD system without attenuation correction. MCD images were first interpreted without knowledge of the DPET findings. In a second reading, MCD and DPET were evaluated simultaneously. Results: The phantom studies revealed a comparable spatial resolution for DPET and MCD (5.9 × 6.3 × 4.2 mm vs. 5.9 × 6.5 × 6.0 mm). System sensitivity of MCD was less compared to DPET (91 cps/Bq/ml/cmF0V vs. 231 cps/ Bq/ml/cmFOv). At a lesion-to-background ratio of 4:1, DPET depicted a minimal phantom lesion of 1.0 cm in diameter, MCD a minimal lesion of 1.6 cm. With DPET, a total of 91 lesions in 27 patients were classified as malignant. MCD without knowledge of DPET results revealed increased FDG uptake in all patients with positive DPET findings. MCD detected 72 out of 91 DPET lesions (79.1 %). With knowledge of the DPET findings, 11 additional lesions were detected (+12%). MCD missed lesions in six patients with relevance for staging in two patients. All lesions with a diameter above 18 mm were detected. Conclusion: MCD FDG imaging yielded results comparable to dedicated PET in most patients. However, a considerable number of small lesions clearly detectable with DPET were not detected by MCD alone. Therefore, MCD cannot yet replace dedicated PET in all oncological FDG studies. Further technical refinement of this new method is needed to improve image quality (e.g. attenuation correction).

Top-Ten Tips for Dual-Energy CT in MSK Radiology

2019 ◽  
Vol 23 (04) ◽  
pp. 392-404 ◽  
Author(s):  
Frances E. Walstra ◽  
Jonathan Hickle ◽  
Peter Duggan ◽  
Rashid Alsharhan ◽  
Nicolas Murray ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dual Energy ◽  
Lesion Detection ◽  
Future Application ◽  
Dual Energy Ct ◽  
Ct Arthrography ◽  
Musculoskeletal Pathology ◽  
Conventional Ct ◽  
Clinical Potential ◽  
Collagen Analysis

Dual-energy computed tomography (DECT) has the potential to detect musculoskeletal pathology with greater sensitivity than conventional CT alone at no additional radiation dose to the patient. It therefore has the potential to reduce the need for further diagnostic imaging or procedures (e.g., joint aspirations in the case of gout or magnetic resonance imaging to confirm undisplaced fractures).DECT is a well-established technique for the detection of gout arthropathy. Multiple newer applications have shown clinical potential including bone marrow edema detection and metal artifact reduction. Collagen analysis, bone marrow lesion detection, and iodine mapping in CT arthrography are areas of possible future application and development.This article outlines 10 tips on the use of DECT imaging of the musculoskeletal system, explaining the technique and indications with practical suggestions to help guide the radiologist.

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