The Predictive Value of the Eighth Edition of the Clinical TNM Staging System for the Likelihood of Eye Salvage for Intraocular Retinoblastoma by Systemic Chemotherapy and Focal Therapy

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yacoub A. Yousef ◽  
Mona Mohammad ◽  
Mustafa Mehyar ◽  
Iyad Sultan ◽  
Maysa Al-Hussaini ◽  
...  
Keyword(s):  
Predictive Value ◽  
Systemic Chemotherapy ◽  
Staging System ◽  
Focal Therapy ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Intraocular Retinoblastoma ◽  
Eighth Edition

New and Important Changes in the TNM Staging System for Breast Cancer

2018 ◽  
pp. 457-467 ◽  
Author(s):  
Gabriel N. Hortobagyi ◽  
Stephen B. Edge ◽  
Armando Giuliano
Keyword(s):  
Breast Cancer ◽  
Regional Lymph Node ◽  
Staging System ◽  
Distant Metastases ◽  
Tnm Staging ◽  
Pathology Report ◽  
Imaging Evaluation ◽  
Complete Surgical Excision ◽  
Tnm Staging System ◽  
Eighth Edition

Expanded understanding of biologic factors that modulate the clinical course of malignant disease have led to the gradual integration of biomarkers into staging classifications. The American Joint Committee on Cancer (AJCC) TNM staging system is universally used and has largely displaced other staging classifications for most, although not all, cancers. Many of the chapters of the eighth edition of the AJCC TNM staging system integrated biomarkers with anatomic definitions. The Breast Chapter added estrogen receptor (ER) and progesterone receptor (PR) expression, HER2 expression, and/or amplification and histologic grade to the anatomic assessment of tumor size, regional lymph node involvement, and distant metastases (known as TNM). While preserving an anatomic staging system for continuity and for regions where modern biomarkers are not always available, the eighth edition emphasizes the increased prognostic precision of the clinical prognostic stage groups and the pathologic prognostic stage groups. The clinical prognostic stage groups are applicable to all patients with primary breast cancer before any treatment has been implemented, but require a clinical and imaging evaluation as well as a biopsy with grade and available ER, PR, and HER2 results; the pathologic prognostic stage groups are applicable to all patients treated with complete surgical excision as first treatment and also require a complete pathology report, grade, and ER, PR, and HER2. Applying the pathologic prognostic stage groups to a large database of patients staged by basic TNM groupings changed the stage grouping of almost 40% of patients. Grouping by pathologic prognostic stage groups led to a better prognostic distribution of the group and more precise individual prognostication.

scholarly journals International Validation of the Eighth Edition of the American Joint Committee on Cancer (AJCC) TNM Staging System in Patients With Resected Pancreatic Cancer

JAMA Surgery ◽  
2018 ◽  
Vol 153 (12) ◽  
pp. e183617 ◽  
Author(s):  
Stijn van Roessel ◽  
Gyulnara G. Kasumova ◽  
Joanne Verheij ◽  
Robert M. Najarian ◽  
Laura Maggino ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
American Joint Committee ◽  
Tnm Staging System ◽  
Eighth Edition

scholarly journals Clinical Validation of the Prognostic Stage Groups of the Eighth-Edition TNM Staging for Medullary Thyroid Carcinoma

2018 ◽  
Vol 103 (12) ◽  
pp. 4609-4616 ◽  
Author(s):  
So Young Park ◽  
Yoon Young Cho ◽  
Hye In Kim ◽  
Jun-Ho Choe ◽  
Jung-Han Kim ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Staging System ◽  
Predictive Performance ◽  
Tnm Staging ◽  
Cancer Specific Survival ◽  
Prognostic Performance ◽  
Medullary Thyroid ◽  
Tnm Staging System ◽  
Eighth Edition

Abstract Context Despite advances in thyroid cancer staging systems, considerable controversy about the current staging system for medullary thyroid carcinoma (MTC) continues. Objective We aimed to evaluate the prognostic performance of the current eighth edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control TNM staging system (TNM-8) and the alternative proposed prognostic stage groups based on recursive partitioning analysis (TNM-RPA). Design, Setting, and Patients We retrospectively analyzed 182 patients with MTC treated at a single tertiary Korean hospital between 1995 and 2015. Interventions and Main Outcome Measures Survival analysis was conducted according to TNM-8 and TNM-RPA. The area under the receiver-operating characteristic curve (AUC), the proportion of variation explained (PVE), and the Harrell concordance index (C-index) were used to evaluate predictive performance. Results Under TNM-8, only two (1.1%) patients were downstaged compared with the seventh edition of the AJCC TNM staging system (TNM-7). The AUC at 10 years, PVE, and C-index were 0.679, 8.7%, and 0.744 for TNM-7 and 0.681, 8.9%, and 0.747 for TNM-8, respectively. Under TNM-RPA, 104 (57.14%) patients were downstaged compared with TNM-8. TNM-RPA had better prognostic performance with respect to cancer-specific survival (AUC at 10 years, 0.750; PVE, 20.9%; C-index, 0.881). Conclusions The predictive performance of the revised TNM-8 in patients with MTC has not changed despite its modification from TNM-7. The proposed changes in TNM-RPA were statistically valid and may present a more reproducible system that better estimates cancer-specific survival of individual patients.

Improved prognostic value of the eighth edition of the AJCC/TNM staging system for differentiated thyroid cancer

2018 ◽  
Author(s):  
Velsen Evert van ◽  
Merel Stegenga ◽  
Kemenade Folkert van ◽  
Boen Kam ◽  
Ginhoven Tessa van ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Value ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Eighth Edition
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