Periosteal Ewing Sarcoma Family of Tumors of the Femur Confirmed by Molecular Detection of EWS-FLI1 Fusion Gene Transcripts

2007 ◽  
Vol 29 (8) ◽  
pp. 561-565 ◽  
Author(s):  
Michiyuki Hakozaki ◽  
Hiroshi Hojo ◽  
Takahiro Tajino ◽  
Hitoshi Yamada ◽  
Atsushi Kikuta ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Molecular Detection ◽  
Fusion Gene ◽  
Gene Transcripts

PML-RARalpha fusion gene transcripts and biological features in acute promyelocytic leukemia patients

2006 ◽  
Vol 28 (2) ◽  
pp. 126-129 ◽  
Author(s):  
R. A. M. MELO ◽  
J. F. VASCONCELLOS ◽  
F. C. B. C. MELO ◽  
C. G. F. MACHADO ◽  
T. M. S. LACERDA ◽  
...  
Keyword(s):  
Acute Promyelocytic Leukemia ◽  
Fusion Gene ◽  
Promyelocytic Leukemia ◽  
Biological Features ◽  
Gene Transcripts

scholarly journals Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors

Science ◽  
2018 ◽  
Vol 361 (6405) ◽  
pp. eaam8419 ◽  
Author(s):  
Nathaniel D. Anderson ◽  
Richard de Borja ◽  
Matthew D. Young ◽  
Fabio Fuligni ◽  
Andrej Rosic ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Ewing Sarcoma ◽  
Rna Binding ◽  
Fusion Gene ◽  
Soft Tissue Tumors ◽  
Gene Fusions ◽  
Gene Encoding ◽  
Reciprocal Translocations ◽  
Whole Genomes ◽  
Genomic Regions

Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between EWSR1, a gene encoding an RNA binding protein, and E26 transformation-specific (ETS) transcription factors. We explored how and when EWSR1-ETS fusions arise by studying the whole genomes of Ewing sarcomas. In 52 of 124 (42%) of tumors, the fusion gene arises by a sudden burst of complex, loop-like rearrangements, a process called chromoplexy, rather than by simple reciprocal translocations. These loops always contained the disease-defining fusion at the center, but they disrupted multiple additional genes. The loops occurred preferentially in early replicating and transcriptionally active genomic regions. Similar loops forming canonical fusions were found in three other sarcoma types. Chromoplexy-generated fusions appear to be associated with an aggressive form of Ewing sarcoma. These loops arise early, giving rise to both primary and relapse Ewing sarcoma tumors, which can continue to evolve in parallel.

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