Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi

2020 ◽  
Vol 44 (6) ◽  
pp. 849-858 ◽  
Author(s):  
Lucy M. Han ◽  
James P. Grenert ◽  
Arun P. Wiita ◽  
Molly Quinn ◽  
Victor Y. Fujimoto ◽  
...  
Keyword(s):  
Hydatidiform Mole ◽  
Chorionic Villi ◽  
Partial Hydatidiform Mole ◽  
Products Of Conception ◽  
Morphologic Appearance

scholarly journals The Contribution of QF-PCR and Pathology Studies in the Diagnosis of Diandric Triploidy/Partial Mole

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1811
Author(s):  
Leticia Benítez ◽  
Montse Pauta ◽  
Cèlia Badenas ◽  
Irene Madrigal ◽  
Alfons Nadal ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Hydatidiform Mole ◽  
Saliva Sample ◽  
Pcr Analysis ◽  
Parental Origin ◽  
Chorionic Villi ◽  
Partial Hydatidiform Mole ◽  
Products Of Conception ◽  
Partial Mole ◽  
Fluorescent Polymerase Chain Reaction

Objective: the aim of our study was to assess the contribution of quantitative fluorescent polymerase chain reaction (QF-PCR) and pathology studies in the diagnosis of diandric triploidies/partial hydatidiform moles. Methods: this study included all fet al triploidies diagnosed by QF-PCR in chorionic villi or amniotic fluid in the 2 centers of BCNatal in which a maternal saliva sample was used to establish its parental origin. Pathology studies were performed in products of conception and concordance between a partial hydatidiform mole diagnosis and the finding of a diandric triploidy was assessed. Results: among 46 fetal triploidies, found in 13 ongoing pregnancies and in 33 miscarriages, there were 26 (56%) diandric triploidies. Concordant molecular (diandric triploidy) and pathology results (partial mole) were achieved in 14 cases (54%), while in 6 cases (23%) pathology studies were normal, and in the remaining 6 cases (23%) pathology studies could not be performed because miscarriage was managed medically. Conclusions: diandric triploidy is associated with partial hydatidiform mole and its diagnosis is crucial to prevent the development of persistent trophoblastic disease. QF-PCR analysis in chorionic villi or amniotic fluid provides a more accurate diagnosis of the parental origin of triploidy than the classical pathology studies.

scholarly journals A Case of Invasive Mole

2017 ◽  
Vol 12 (2) ◽  
pp. 86-87
Author(s):  
Shahana Ahmed ◽  
Dipti Rani Shaha
Keyword(s):  
Hydatidiform Mole ◽  
The Body ◽  
Emergency Laparotomy ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Partial Hydatidiform Mole ◽  
Normal Limits ◽  
History Of ◽  
Invasive Mole

Invasive mole is a condition where a molar pregnancy, such as a partial hydatidiform mole or complete hydatidiform mole, invades the wall of the uterus, potentially spreading and metastasizing to other parts of the body. Here is a case who presented with history of evacuation for molar pregnancy. She presented with irregular P/V bleeding on and off and after admission silent perforation with massive haemoperitoneum was detected for which emergency laparotomy was done. She recovered and was followed up till her b-hCG levels were within normal limits. As patient presented to us with haemoperitoneum and on laparotomy, there was invasion into whole of the uterus, it could not be saved and hysterectomy was done.Faridpur Med. Coll. J. Jul 2017;12(2): 86-87

Partial Hydatidiform Mole

1993 ◽  
Vol 12 (4) ◽  
pp. 315-323 ◽  
Author(s):  
M. D. Jeffers ◽  
P. OʼDwyer ◽  
B. Curran ◽  
M. Leader ◽  
J. E. Gillan
Keyword(s):  
Hydatidiform Mole ◽  
Partial Hydatidiform Mole

scholarly journals Partial hydatidiform mole evolving into metastatic trophoblastic tumor: case report

2020 ◽  
Vol 9 (4) ◽  
pp. 1713
Author(s):  
I. Elmouri ◽  
S. Tanouti ◽  
H. Taheri ◽  
H. Saadi ◽  
A. Mimouni
Keyword(s):  
Case Report ◽  
Therapeutic Strategy ◽  
Histopathological Examination ◽  
Hydatidiform Mole ◽  
Myometrial Invasion ◽  
Multiparous Woman ◽  
Partial Hydatidiform Mole ◽  
Non Invasive ◽  
Trophoblastic Tumor ◽  
Partial Mole

Partial hydatidiform mole can evolve into a metastatic trophoblastic tumor. A 36-year-old, multiparous woman, pregnant with a 22-week embryonic hydatidiform mole, having spontaneously expelled. Histopathological examination showed a non-invasive partial mole. During biological monitoring, a trophoblastic tumor was diagnosed with pulmonary metastasis on CT-scan and myometrial invasion by MRI. Authors opted for a monochemotherapy with a good evolution. The potential risk of malignant transformation of the partial hydatidiform mole requires an adequate therapeutic strategy with strict monitoring.

A Large Yolk Sac: A Possible Clue to Early Diagnosis of Partial Hydatidiform Mole

1994 ◽  
Vol 22 (8) ◽  
pp. 519-521 ◽  
Author(s):  
Y. Zalel ◽  
E. Shalev ◽  
N. Yanay ◽  
E. Schiff ◽  
E. Weiner
Keyword(s):  
Early Diagnosis ◽  
Hydatidiform Mole ◽  
Yolk Sac ◽  
Partial Hydatidiform Mole

scholarly journals Parental Origin and Phenotype of Triploidy in Spontaneous Abortions: Predominance of Diandry and Association with the Partial Hydatidiform Mole

2000 ◽  
Vol 66 (6) ◽  
pp. 1807-1820 ◽  
Author(s):  
Michael V. Zaragoza ◽  
Urvashi Surti ◽  
Raymond W. Redline ◽  
Elise Millie ◽  
Aravinda Chakravarti ◽  
...  
Keyword(s):  
Hydatidiform Mole ◽  
Parental Origin ◽  
Spontaneous Abortions ◽  
Partial Hydatidiform Mole

Partial hydatidiform mole following intracytoplasmic sperm injection and assisted zona hatching

2002 ◽  
Vol 109 (8) ◽  
pp. 964-966 ◽  
Author(s):  
Simon J. Wood ◽  
Victoria Sephton ◽  
Tom Searle ◽  
Stephen Troup ◽  
Charles Kingsland
Keyword(s):  
Intracytoplasmic Sperm Injection ◽  
Hydatidiform Mole ◽  
Partial Hydatidiform Mole
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