P16/CDKN2A and Ki-67 Enhance the Detection of Anal Intraepithelial Neoplasia and Condyloma and Correlate With Human Papillomavirus Detection by Polymerase Chain Reaction

2010 ◽  
Vol 34 (10) ◽  
pp. 1449-1455 ◽  
Author(s):  
Edyta C. Pirog ◽  
Koen D. Quint ◽  
Rhonda K. Yantiss
Keyword(s):  
Polymerase Chain Reaction ◽  
Human Papillomavirus ◽  
Intraepithelial Neoplasia ◽  
Anal Intraepithelial Neoplasia ◽  
Chain Reaction ◽  
Ki 67 ◽  
Polymerase Chain

scholarly journals Value of cytologic Papanicolaou smears and polymerase chain reaction screening for human papillomavirus DNA in detecting anal intraepithelial neoplasia

Cancer ◽  
2012 ◽  
Vol 118 (24) ◽  
pp. 6031-6038 ◽  
Author(s):  
Isabelle Etienney ◽  
Sarra Vuong ◽  
Ali Si-Mohamed ◽  
Jean-François Fléjou ◽  
Patrick Atienza ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Human Papillomavirus ◽  
Intraepithelial Neoplasia ◽  
Anal Intraepithelial Neoplasia ◽  
Chain Reaction ◽  
Papanicolaou Smears ◽  
Polymerase Chain ◽  
Papillomavirus Dna

Human Papillomavirus Type, Proliferative Activity, and p53

2000 ◽  
Vol 124 (5) ◽  
pp. 721-724
Author(s):  
R. Rabah ◽  
W. Sakr ◽  
R. Thomas ◽  
W. D. Lancaster ◽  
L. Gregoire
Keyword(s):  
Polymerase Chain Reaction ◽  
Human Papillomavirus ◽  
Virus Type ◽  
Predictive Value ◽  
Immunohistochemical Analysis ◽  
Suppressor Gene ◽  
Chain Reaction ◽  
Laryngeal Papillomatosis ◽  
Ki 67 ◽  
Polymerase Chain

Abstract Context.—The predictive value of nuclear proliferation antigen (Ki-67), tumor suppressor gene product p53, and human papillomavirus type has not been evaluated for outcome of laryngeal papilloma. Objective.—This study was designed to determine whether immunohistochemical analysis of Ki-67 and p53 and human papillomavirus typing by polymerase chain reaction are able to identify patients with a more aggressive course of laryngeal papillomatosis. Design.—Immunohistochemistry and polymerase chain reaction were performed on archival, paraffin-embedded, laryngeal papillomatosis biopsy specimens at the time of diagnosis, at an intermediate time during treatment, and at the last procedure available. Staining indexes for Ki-67 and p53 were determined, and human papillomavirus type was analyzed for all biopsies. Patients.—Twelve patients with recurrent laryngeal papillomatosis for at least 5 years were selected from patients treated at our institution during the last 20 years. Main Outcome Measures.—Separate analyses were conducted comparing average Ki-67 and p53 indexes against disease outcome, viral type, or average number of procedures per year. Associations were analyzed between virus type, average number of procedures per year, outcome, and histology. Results.—No statistically significant associations were noted in Ki-67 or p53 indexes and outcome. Weak associations were noted for p53 indexes and procedures per year and virus type. Weak associations also were noted between virus type and development of neoplasia. Conclusions.—Our observations suggest that human papillomavirus typing may be helpful in identifying patients with aggressive recurrent laryngeal papillomatosis. The weak association between p53 indexes and procedures per year and virus type may have some predictive value in identifying aggressive lesions.

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