Intravascular large B-cell lymphoma presenting as cauda equina syndrome and showing aberrant cytokeratin expression: a diagnostic challenge

Pathology ◽  
2014 ◽  
Vol 46 (3) ◽  
pp. 241-244 ◽  
Author(s):  
Béma Coulibaly ◽  
Laura Mesturoux ◽  
Barbara Petit ◽  
Laurent Magy ◽  
François Labrousse
Keyword(s):  
B Cell ◽  
Cauda Equina Syndrome ◽  
Cell Lymphoma ◽  
Cauda Equina ◽  
B Cell Lymphoma ◽  
Diagnostic Challenge ◽  
Large B Cell Lymphoma ◽  
Cytokeratin Expression ◽  
Large B Cell

scholarly journals SACRAL DIFFUSE LARGE B-CELL LYMPHOMA PRESENTED AS CAUDA EQUINA SYNDROME. Case report and systemic review.

2021 ◽  
Author(s):  
Humberto Foyaca-Sibat
Keyword(s):  
B Cell ◽  
Cauda Equina Syndrome ◽  
Cell Lymphoma ◽  
Cauda Equina ◽  
B Cell Lymphoma ◽  
Systemic Review ◽  
Extensive Literature ◽  
Large B Cell Lymphoma ◽  
Uncommon Condition ◽  
Large B Cell

ABSTRACT: Background: Cauda equina syndrome secondary (CES) to primary sacral diffuse large B cell lymphoma (DLBCL) is an uncommon condition, and few cases have been reported in the medical literature. After an extensive literature review related to these topics, we did not find a reported case like our patient.

Cauda equina syndrome due to large B-cell lymphoma: a case report

2016 ◽  
Vol 37 (5) ◽  
pp. 825-827 ◽  
Author(s):  
Vincenzo Belcastro ◽  
Silvio Bellcocchi ◽  
Carlo Patriarca ◽  
Gigliola Gini ◽  
Mirko Piola ◽  
...  
Keyword(s):  
Case Report ◽  
B Cell ◽  
Cauda Equina Syndrome ◽  
Cell Lymphoma ◽  
Cauda Equina ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Diffuse Large B-Cell Lymphoma With Striking Intrasinusoidal Pseudoglandular Growth Pattern as a Diagnostic Dilemma Mimicking Metastatic Poorly Differentiated Pancreatic Adenocarcinoma in an Intraabdominal Lymph Node

2018 ◽  
Vol 27 (2) ◽  
pp. 181-184 ◽  
Author(s):  
David Yau ◽  
Manju Aron ◽  
Imran N. Siddiqi
Keyword(s):  
Lymph Node ◽  
B Cell ◽  
Growth Pattern ◽  
Cell Lymphoma ◽  
Frozen Section ◽  
B Cell Lymphoma ◽  
Diagnostic Challenge ◽  
Diagnostic Dilemma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

We report an unusual intrasinusoidal growth pattern of an intraabdominal diffuse large B-cell lymphoma both clinically and histologically mimicking a metastatic adenocarcinoma. A 66-year-old woman presented with a high-grade distal biliary stricture with multiple enlarged abdominal lymph nodes. Frozen section at the time of pancreatoduodenectomy (“Whipple”) demonstrated cohesive nests of large atypical cells within a totally effaced lymph node presenting a diagnostic challenge. Immunohistochemistry proved this to be a diffuse large B-cell lymphoma extensively involving the sinusoids.

scholarly journals LUNG AS THE PRIMARY SOURCE OF INTRAVASCULAR LARGE B CELL LYMPHOMA: A DIAGNOSTIC CHALLENGE

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A2006-A2007
Author(s):  
Alyssa Foster ◽  
Dan Ran-Castillo ◽  
Matthew Tavares ◽  
Jonathan Shammash ◽  
Manuel Katz ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Primary Source ◽  
B Cell Lymphoma ◽  
Diagnostic Challenge ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Pulmonary Intravascular B-Cell Lymphoma with Angiotropism/Angioinvasion Mimicking Interstitial Lung Disease: A Clinical Dilemma and Potential Diagnostic Challenge

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Florentina Matea ◽  
Salem Alowami ◽  
Michael Bonert ◽  
Monalisa Sur ◽  
Yaron Shargall ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Skin Lesions ◽  
Lymphoid Cells ◽  
Diagnostic Challenge ◽  
Rare Type ◽  
Large B Cell Lymphoma ◽  
Clinical Dilemma ◽  
Large B Cell

Intravascular large B cell lymphoma (IVLBCL) is a rare type of extranodal diffuse large B-cell lymphoma. Patients typically present with nonspecific findings, particularly bizarre neurologic symptoms, fever, and skin lesions. IVLBCL with primary lung presentation is very rare and difficult to diagnose. The authors report a case of a 75-year-old male who presented with neurological symptoms and showed diffuse pulmonary ground glass opacities on computed tomography scan (CT scan). Surgical lung biopsy was performed. Light microscopic examination of the specimen showed diffuse alveolar septal widening caused by neoplastic lymphocytes, which were positive for CD20. These atypical lymphoid cells also demonstrated angiotropism/angioinvasion of the medium sized pulmonary vessels. The patient was diagnosed with IVLBCL and underwent chemotherapy. The patient is still alive 12 months after diagnosis.

scholarly journals All That Wheezes Is Not Asthma: A Case of Diffuse Large B-Cell Lymphoma of the Larynx

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Bushra Rahman ◽  
Jawad Bilal ◽  
Qurat Ul Ain Riaz Sipra ◽  
Irbaz Bin Riaz
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Laryngeal Neoplasms ◽  
Diagnostic Challenge ◽  
Large B Cell Lymphoma ◽  
Acute Airway Obstruction ◽  
High Index Of Suspicion ◽  
Large B Cell

Localized laryngeal lymphoma is a rare entity with an incidence of less than 1% of all laryngeal neoplasms. Diffuse large B-cell lymphoma (DLBCL) is the most common type of laryngeal neoplasms. Here, we describe a case of a young 28-year-old female with large B-cell lymphoma who remained undiagnosed for a long time owing to a myriad of nonspecific presentation including “wheezing.” Although primary laryngeal lymphomas constitute a diagnostic challenge since they are rare, one should have a high index of suspicion for lymphoma of the larynx in patients presenting with unresolved wheezing as it can present catastrophically with acute airway obstruction requiring immediate surgical intervention which was observed in this case. Treatment includes radiotherapy, chemotherapy, immunotherapy, or a combination of these. We hope that the discussions ensuing from case reports regarding uncommon presentations of laryngeal lymphoma may spur the formation of regional/international databases for the description of lymphomas with unusual presentations. This effort can lead to in-depth study of cases and prompt awareness of “rare and subtle presentations” of laryngeal lymphoma.

scholarly journals A Case of Chemotherapy-Refractory “THRLBCL like Transformation of NLPHL” Successfully Treated with Lenalidomide

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Mamatha Siricilla ◽  
Lydia Irwin ◽  
Andres Ferber
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Aggressive Lymphoma ◽  
Diagnostic Challenge ◽  
Cell Markers ◽  
Non Hodgkin Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of nonclassical Hodgkin lymphoma (HL). It resembles non-Hodgkin lymphoma (NHL), by expressing classic B cell markers such as CD20 and CD79a however lacks definitive HL markers (such as CD15 and CD30). T cell histiocyte-rich large B cell lymphoma (THRLBCL), on the other hand, is a distinct entity classified under NHL and considered a variant of diffuse large B cell lymphoma (DLBCL). NLPHL can look morphologically and immunologically similar to THRLBCL and often poses a diagnostic challenge. Neoplastic cells in both NLPHL and THRLBCL express B cell markers and are typically scattered in a background of reactive cells. The two major differences are the background cell type and the morphologic pattern. Despite having a phenotypic resemblance, they have distinct biologic behavior and clinical course. NLPHL typically has an indolent course, and THRLBCL has an aggressive course. Hence, differentiating these two entities is critical not only for prognosis but for treatment purposes. Of note, NLPHL has a small risk of transformation to an aggressive lymphoma such as THRLBCL.

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