Does Provision of Point-of-Care CD4 Technology and Early Knowledge of CD4 Levels Affect Early Initiation and Retention on Antiretroviral Treatment in HIV-Positive Pregnant Women in the Context of Option B+ for PMTCT?

2014 ◽  
Vol 67 ◽  
pp. S139-S144 ◽  
Author(s):  
Alexio-Zambezi Mangwiro ◽  
Kudzai Makomva ◽  
Antoinette Bhattacharya ◽  
Gaurav Bhattacharya ◽  
Tendai Gotora ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Antiretroviral Treatment ◽  
Point Of Care ◽  
Early Initiation ◽  
Hiv Positive

scholarly journals Comparison of point-of-care versus laboratory-based CD4 cell enumeration in HIV-positive pregnant women

2013 ◽  
Vol 16 (1) ◽  
pp. 18649 ◽  
Author(s):  
Landon Myer ◽  
Kristen Daskilewicz ◽  
James McIntyre ◽  
Linda-Gail Bekker
Keyword(s):  
Pregnant Women ◽  
Point Of Care ◽  
Hiv Positive ◽  
Cell Enumeration ◽  
Cd4 Cell

Blessing’s (Life) Story: An Adolescent in Residential Care Living with HIV

2019 ◽  
Vol 31 (2) ◽  
Author(s):  
Jenita Chiba ◽  
Jeanette Schmid
Keyword(s):  
Identity Formation ◽  
Residential Care ◽  
Antiretroviral Treatment ◽  
Service Providers ◽  
Life Story ◽  
Care Facility ◽  
Hiv Positive ◽  
Residential Care Facility ◽  
Living With Hiv ◽  
Specific Construction

The lifespan of perinatally HIV-infected children in South Africa has increased owing to the availability of antiretroviral treatment, allowing growth into adolescence and beyond. There is limited knowledge of the lived realities of adolescents with HIV. This paper, using life story methodology and based on Blessing’s narrative, provides an intersectional, complex view of the experience of one such teenager who is perinatally HIV-positive, was abandoned by his family and is living in a residential care facility. His story powerfully illuminates the specific construction of adolescence in this context, focusing on identity formation and the need for connection. The narrative also points to service providers’ practice when engaged with such youths.

The performance of a new point-of-care HIV virus load technology to identify patients failing antiretroviral treatment

2020 ◽  
Vol 122 ◽  
pp. 104212
Author(s):  
Diana Mariani ◽  
Marcelo C.V.M. de Azevedo ◽  
Isabelle Vasconcellos ◽  
Luiz Ribeiro ◽  
Cassia Alves ◽  
...  
Keyword(s):  
Antiretroviral Treatment ◽  
Point Of Care ◽  
Virus Load ◽  
Hiv Virus

scholarly journals ACE2, TMPRSS2 and L-SIGN expression in placentae from HIV-positive pregnancies exposed to antiretroviral therapy–implications for SARS-CoV-2 placental infection

2021 ◽  
Author(s):  
Smriti Kala ◽  
Ksenia Meteleva ◽  
Lena Serghides
Keyword(s):  
Antiretroviral Therapy ◽  
Pregnant Women ◽  
Viral Entry ◽  
Cell Entry ◽  
Hiv Positive ◽  
Mrna Levels ◽  
Black Race ◽  
Entry Receptor ◽  
Lower Expression ◽  
Human Placentae

Abstract Background SARS-CoV-2 binding receptor ACE2 and the spike protein priming protease TMPRSS2 are co-expressed in human placentae. It is unknown whether their expression is altered in the context of HIV infection and antiretroviral therapy (ART). Methods We compared mRNA levels of SARS-CoV-2 cell-entry mediators ACE2, TMPRSS2 and L-SIGN (an alternative entry receptor) by qPCR in 105 placentae: 45 from pregnant women with HIV (WHIV) exposed to protease inhibitor (PI)-based ART, 17 from WHIV on non-PI-based ART, and 43 from HIV-uninfected women. Results ACE2 levels were lower, while L-SIGN levels were higher in placentae from WHIV on PI-based ART as compared to those on non-PI-based ART and to HIV-uninfected women. TMPRSS2 levels were similar between groups. Black race was significantly associated with lower expression of ACE2 and higher expression of L-SIGN. ACE2 levels were significantly higher in placentae of female fetuses. Discussion We have identified pregnant women of Black race and WHIV who are on PI-based ART to have relatively lower expression of placental ACE2 than those of White race and HIV-uninfected women. This effect may potentially contribute to altered susceptibility to COVID-19 in these women, either favorably; by reduced viral entry, or detrimentally; by loss of ACE2 protection against hyperinflammation.

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