Hypoxia and Amino Acid Imaging of High-Grade Glioma

2020 ◽  
Vol 45 (6) ◽  
pp. e290-e293
Author(s):  
Paola Mapelli ◽  
Federico Fallanca ◽  
Paola Scifo ◽  
Maurizio Barbera ◽  
Antonella Castellano ◽  
...  
Keyword(s):  
Amino Acid ◽  
High Grade Glioma ◽  
High Grade

scholarly journals A systematic review of the utility of amino acid PET in assessing treatment response to bevacizumab in recurrent high-grade glioma

2021 ◽  
Author(s):  
Kendall L Hughes ◽  
Christen M O’Neal ◽  
Bethany J Andrews ◽  
Alison M Westrup ◽  
James D Battiste ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amino Acid ◽  
High Grade Glioma ◽  
High Grade ◽  
Inclusion Criteria ◽  
Early Treatment Failure ◽  
Search Terms ◽  
Amino Acid Pet ◽  
Improving Accuracy ◽  
Induced Changes

Abstract Currently, bevacizumab (BEV), an antiangiogenic agent, is used as an adjunctive therapy to re-irradiation and surgery in patients with recurrent high-grade gliomas (rHGG). BEV has shown to decrease enhancement on MRI, but it is often unclear if these changes are due to tumor response to BEV or treatment-induced changes in the blood brain barrier. Preliminary studies show that amino acid PET can aid in distinguishing these changes on MRI.The authors performed a systematic review of PubMed and Embase through July 2020 with the search terms ‘bevacizumab’ or ‘Avastin’ and ‘recurrent glioma’ and ‘PET,’ yielding 38 papers, with 14 meeting inclusion criteria. Thirteen out of fourteen studies included in this review used static PET and three studies used dynamic PET to evaluate the use of BEV in rHGG. Six studies used the amino acid tracer [ 18F]FET, four studies used [ 11C]MET, and four studies used [ 18F]FDOPA. [ 18F]FET, [ 11C]MET, and [ 18F]FDOPA PET in combination with MRI have shown promising results for improving accuracy in diagnosing tumor recurrence, detecting early treatment failure, and distinguishing between tumor progression and treatment-induced changes in patients with rHGG treated with BEV.

scholarly journals Comparison of the Amino Acid Tracers 18F-FET and 18F-DOPA in High-Grade Glioma Patients

2014 ◽  
Vol 55 (10) ◽  
pp. 1611-1616 ◽  
Author(s):  
C. Lapa ◽  
T. Linsenmann ◽  
C. M. Monoranu ◽  
S. Samnick ◽  
A. K. Buck ◽  
...  
Keyword(s):  
Amino Acid ◽  
High Grade Glioma ◽  
High Grade

Prognostic Factors in Patients Diagnosed with High Grade Glioma Managed with Radiotherapy: Experience at the Federico Gómez Children's Hospital of Mexico

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
María Fátima Chilaca-Rosas ◽  
Heynar de Jesús Pérez-Villanueva ◽  
Noé Trinidad-Hernández ◽  
Juan Carlos Heredia-Gutiérrez ◽  
Héctor Urueta-Cuéllar
Keyword(s):  
Prognostic Factors ◽  
High Grade Glioma ◽  
High Grade ◽  
Children's Hospital ◽  
Children’S Hospital
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