Alpha7 Nicotine Acetylcholine Receptor Agonist PNU-282987 Attenuates Acute Lung Injury in a Cardiopulmonary Bypass Model in Rats

Shock ◽  
2017 ◽  
Vol 47 (4) ◽  
pp. 474-479 ◽  
Author(s):  
Jiaxi Ge ◽  
Jie Tian ◽  
Hao Yang ◽  
Lei Hou ◽  
Zhankui Wang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Cardiopulmonary Bypass ◽  
Lung Injury ◽  
Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Nicotine Acetylcholine Receptor

scholarly journals Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury

2018 ◽  
Vol Volume 11 ◽  
pp. 169-178 ◽  
Author(s):  
Mario Menk ◽  
Jan Adriaan Graw ◽  
Clarissa von Haefen ◽  
Henrik Kurt Alexander Steinkraus ◽  
Burkhard Lachmann ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Angiotensin Ii ◽  
Lung Injury ◽  
Receptor Agonist ◽  
Pulmonary Inflammation ◽  
Compound 21

scholarly journals The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model

2020 ◽  
Vol 68 (8) ◽  
pp. 785-792
Author(s):  
Tatsuya Itonaga ◽  
Shingo Hirao ◽  
Kazuhiro Yamazaki ◽  
Tadashi Ikeda ◽  
Kenji Minatoya ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Cardiopulmonary Bypass ◽  
Lung Injury

A rise of MMP-2 and MMP-9 in bronchoalveolar lavage fluid is associated with acute lung injury after cardiopulmonary bypass in a swine model

Perfusion ◽  
2003 ◽  
Vol 18 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Wolfgang Eichler ◽  
J F Matthias Bechtel ◽  
Jan Schumacher ◽  
Johanna A Wermelt ◽  
Karl-Friedrich Klotz ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Cardiopulmonary Bypass ◽  
Lung Injury ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Swine Model ◽  
Tissue Samples ◽  
Pulmonary Capillary ◽  
A Prospective Study

Postoperative acute lung injury (ALI) contributes to the morbidity and mortality following cardiopulmonary bypass (CPB). To determine whether the presence of matrix metalloproteinases (MMPs) is associated with ALI after CPB, MMP-2 and MMP-9 activities in bronchoalveolar lavage fluid (BALF) were compared with parameters indicating impaired gas exchange. In a prospective study, 17 minipigs were subjected to CPB for 60 min. Before and at five and 180 min after CPB, MMP-2 and MMP-9 were assayed in BALF and the arterial-alveolar gradient of oxygen tension (AaDO2), the pulmonary capillary wedge pressure (PCWP) and the water content of lung tissue samples (Wt) were evaluated and compared with baseline values. MMP-2 and MMP-9 increased significantly 5 minutes (2.1- and 6.2-fold, respectively) and 180 minutes (3.4- and 14.3-fold, respectively) post-CPB. AaDO2 and Wt, but not PCWP, increased significantly 180 minutes after CPB and only AaDO2, but not PCWP or Wt, was significantly correlated with MMP-2 (r/0.66, p/0.006) and MMP-9 (r/0.62, p/0.01). In conclusion, high levels of MMP-2 and MMP-9 in the pulmonary compartment are associated with ALI after CPB.

Modulatory effects of S 38232, a non α-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus

2010 ◽  
Vol 58 (4-5) ◽  
pp. 806-815 ◽  
Author(s):  
Laura Lagostena ◽  
Laurence Danober ◽  
Sylvie Challal ◽  
Pierre Lestage ◽  
Elisabeth Mocaër ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Receptor Agonist ◽  
Network Activity ◽  
Mouse Hippocampus ◽  
Nicotine Acetylcholine Receptor

Lipoxin receptor agonist, may be a potential treatment for hemorrhagic shock-induced acute lung injury

2012 ◽  
Vol 79 (1) ◽  
pp. 92-94 ◽  
Author(s):  
Jie Gong ◽  
Hong-Bin Li ◽  
Si Guo ◽  
You Shang ◽  
Shang-Long Yao
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Receptor Agonist ◽  
Potential Treatment
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