Determinants of Long-Term Graft Outcome in Transplant Glomerulopathy

2010 ◽  
Vol 90 (7) ◽  
pp. 757-764 ◽  
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Rohan John ◽  
Ana Konvalinka ◽  
Ana Tobar ◽  
Sang J. Kim ◽  
Heather N. Reich ◽  
...  
2014 ◽  
Vol 98 ◽  
pp. 612-613
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A. Akdur ◽  
M. Kirnap ◽  
E. Kolsarici ◽  
S. Yildirim ◽  
G. Moray ◽  
...  

2017 ◽  
Vol 78 (5-6) ◽  
pp. 421-427 ◽  
Author(s):  
David F. Pinelli ◽  
John J. Friedewald ◽  
Kelley M.K. Haarberg ◽  
Shree L. Radhakrishnan ◽  
Jennifer R. Zitzner ◽  
...  

1993 ◽  
Vol 56 (6) ◽  
pp. 1368-1371 ◽  
Author(s):  
YASUJI ICHIKAWA ◽  
MITSUO HASHIMOTO ◽  
MICHIO NOJIMA ◽  
MASAHARU SATA ◽  
NOBUMASA FUJIMOTO ◽  
...  
Keyword(s):  

2011 ◽  
Vol 43 (8) ◽  
pp. 2871-2874 ◽  
Author(s):  
A. Kolonko ◽  
J. Chudek ◽  
A. Pawlik ◽  
J. Wilk ◽  
P. Jałowiecki ◽  
...  

2005 ◽  
Vol 37 (4) ◽  
pp. 1716-1717 ◽  
Author(s):  
G. Junge ◽  
S.G. Tullius ◽  
V. Klitzing ◽  
L. Schewior ◽  
J. Pratschke ◽  
...  

2001 ◽  
Vol 33 (1-2) ◽  
pp. 970-971 ◽  
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A. Reutzel-Selke ◽  
S.G. Tullius ◽  
T. Zschockelt ◽  
M. Nieminen-Kelhä ◽  
U. Bachmann ◽  
...  

2000 ◽  
Vol 11 (7) ◽  
pp. 1317-1324
Author(s):  
STEFAN GÜNTHER TULLIUS ◽  
ANJA REUTZEL-SELKE ◽  
FRANK EGERMANN ◽  
MELINA NIEMINEN-KELHÄ ◽  
SVEN JONAS ◽  
...  

Abstract. As a consequence of an advancing discrepancy between supply of suitable grafts and demand from potential recipients, less than optimal organs are increasingly being used. Although clinical studies demonstrate the involvement of various risk factors, including donor age and duration of ischemia on long-term graft outcome, their individual contribution and correlation has not been followed experimentally. After cold ischemic times of 5, 60, and 120 min, kidney allografts of 3-, 12-, and 18-mo-old Fischer 344 donors were transplanted into 3-mo-old Lewis rats. Age-related changes were examined in matched native uninephrectomized controls. Proteinuria and creatinine clearance were determined, and histologic and immunohistologic studies were assessed and quantified at the end of the observation period (20 wk). All grafts functioned satisfactorily with the exception of one graft each from 12- and 18-mo-old donors with prolonged ischemia (120 min). Functional deterioration and structural changes progressed in parallel to increasing donor age and prolonged ischemia. The impact of expanded ischemia was particularly detrimental in grafts from older donor animals. Donor age and duration of ischemia act in a synergistic manner in our model. Brief ischemic times seem of particular relevance when grafts from older donors are being used.


Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A111-A111
Author(s):  
Fenton‐Lee C ◽  
O'Connell Pj ◽  
Kuypers Drj ◽  
Allen Rdm ◽  
Chapman Jr ◽  
...  

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