Kidney Weight and Recipient Body Weight Ratio Predict Long-Term Graft Outcome.

2014 ◽  
Vol 98 ◽  
pp. 612-613
Author(s):  
A. Akdur ◽  
M. Kirnap ◽  
E. Kolsarici ◽  
S. Yildirim ◽  
G. Moray ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Ratio ◽  
Body Weight Ratio ◽  
Kidney Weight ◽  
Graft Outcome

Stimulation of Renal Organic Base Transport by Uranyl Nitrate

1972 ◽  
Vol 50 (6) ◽  
pp. 533-538 ◽  
Author(s):  
G. H. Hirsch
Keyword(s):  
Body Weight ◽  
Uranyl Nitrate ◽  
Weight Ratio ◽  
Male Rats ◽  
Organic Base ◽  
Body Weight Ratio ◽  
Kidney Weight ◽  
Nitrate Treatment ◽  
Cortical Slices ◽  
Stimulation Of

Administration of 6 mg/kg uranyl nitrate to adult male rats resulted in a significant enhancement of N-methylnicotinamide (NMN) uptake by renal cortical slices when measured 24 or 48 h after injection. The accumulation of another organic base, tetraethylammonium (TEA), by renal cortical slices was also significantly increased by uranyl nitrate treatment, but transport of the organic acid p-aminohippurate (PAH) was not altered in these experiments. The kidney weight to body weight ratio was increased in treated rats. Accumulation of NMN by renal cortical slices was significantly enhanced within 8 h after administration of 6 mg/kg uranyl nitrate. NMN uptake was also significantly enhanced 24 and 48 h after administration of 0.5 or 1.0 mg/kg uranyl nitrate to rats. The nephrotoxicity produced by uranyl nitrate was not directly related to its induction of organic base transport. The data support the hypothesis that the organic base transport system can be selectively induced by appropriate stimuli. Treatment of rats with potassium chloride did not enhance NMN uptake by renal cortical slices.

Effect of taxifolin/dapagliflozin combination on colistin-induced nephrotoxicity in rats

2021 ◽  
pp. 096032712110109
Author(s):  
AM Kabel ◽  
SA Salama
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Growth Factor ◽  
Weight Ratio ◽  
Nuclear Factor ◽  
Body Weight Ratio ◽  
Kidney Weight ◽  
Oxidative Stress Parameters ◽  
Tgf Β1 ◽  
Stress Parameters

Colistin is an antimicrobial agent that is used in resistant gram-negative infections. Its most common dose-limiting adverse effect is nephrotoxicity. The objective of our study was to explore the possible effects of each of taxifolin and dapagliflozin alone and in combination on colistin-induced nephrotoxicity in rats. Sixty male rats were randomized into six groups: Control; colistin; colistin + taxifolin; colistin + dapagliflozin; colistin + carboxymethyl cellulose (CMC) and colistin + taxifolin + dapagliflozin. Dapagliflozin, taxifolin, and CMC were given daily for 7 days, 4 hours before colistin injection. Kidney weight/body weight ratio and renal function tests were determined. Renal tissue nerve growth factor-β (NGF-β), transforming growth factor beta 1 (TGF-β1), proinflammatory cytokines, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-κB) p65, signal transducer and activator of transcription 3 (STAT3), oxidative stress parameters, beclin-1 and c-Jun NH2-terminal kinase (JNK) activities were measured. Kidneys were examined histopathologically and immunohistochemically. Taxifolin and/or dapagliflozin induced significant improvement in the renal functions and oxidative stress parameters with significant increase in tissue Nrf2, STAT3 and NGF-β accompanied with significant decrease in kidney weight/body weight ratio, tissue proinflammatory cytokines, TGF-β1, NF-κB (p65), TLR4, beclin-1 and JNK activities and improved the histopathological picture when compared to rats treated with colistin alone. This improvement was significant with taxifolin/dapagliflozin combination compared to rats treated with each of these agents alone. So, we concluded that the combined use of taxifolin and dapagliflozin may confer a therapeutic tool for attenuation of colistin-induced nephrotoxicity.

Effects of growth hormone and thyroxine on kidney insulin-like growth factor-I and renal growth in hypophysectomized rats

1993 ◽  
Vol 136 (3) ◽  
pp. 399-406 ◽  
Author(s):  
S. M. Marshall ◽  
A. Flyvbjerg ◽  
K. D. Jørgensen ◽  
J. Weeke ◽  
H. Ørskov
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Weight Ratio ◽  
Treated Group ◽  
Body Weight Ratio ◽  
Kidney Weight ◽  
Renal Growth ◽  
Factor I ◽  
Igf I ◽  
Hypophysectomized Rats

ABSTRACT The effects of treatment for 11 days with human growth hormone (hGH; 140 μg/day), thyroxine (T4; 3 μg/day) and hGH + T4 on renal growth and content of insulin-like growth factor-I (IGF-I) in hypophysectomized rats have been compared with saline-treated hypophysectomized animals and intact control animals. Right kidney weight and kidney weight/body weight ratio remained low in the saline-treated group (313±9 vs 694±28 mg in controls on day 11, P<0·001 and 3·4±0·12 × 10−3 vs 4·2±0·10× 10−3, P< 0·005 respectively). In T4- and hGH-treated animals, kidney weight gain was similar (to 420 ± 14 and 450±22 mg on day 11 respectively, P>0·05), whilst the increase was greater in the group given hGH + T4 (to 572 ±34 mg, P< 0·001 compared with hGH- and T4-treated groups). The kidney weight/body weight ratio became normal in the T4- and hGH + T4-treated animals but remained low in the hGH-treated group. The renal content of IGF-I was low in the salinetreated animals throughout the study (92±10 ng/g on day 11 vs 219±8 ng/g in control animals, P< 0·001), but increased to a maximum of 88% above baseline on day 1 in the group given T4. In the hGH-and hGH + T4-treated groups, renal IGF-I concentration rose to a peak of 317% above baseline on days 2 to 4, then fell to the values seen in control animals on day 11 (hGH: 242±18 ng/g; hGH + T4: 320 ± 41 ng/g; controls: 219 ± 8 ng/g; P> 0·05 for all comparisons). Thus treatment with hGH or T4 results in similar kidney weight gain, despite a greater rise in the renal concentration of IGF-I in the hGH-treated animals. Treatment with both hGH + T4 leads to an increase in the renal concentration of IGF-I similar to that seen with hGH treatment alone, but a larger increase in kidney weight, suggesting that T4 does not stimulate renal growth via the IGF-I pathway and that growth promotion by hGH and T4 is additive. Journal of Endocrinology (1993) 136, 399–406

scholarly journals Creatine Alleviates Doxorubicin-Induced Liver Damage by Inhibiting Liver Fibrosis, Inflammation, Oxidative Stress, and Cellular Senescence

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 41
Author(s):  
Nouf Aljobaily ◽  
Michael J. Viereckl ◽  
David S. Hydock ◽  
Hend Aljobaily ◽  
Tsung-Yen Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Methylation ◽  
Body Weight ◽  
Liver Fibrosis ◽  
Liver Damage ◽  
Cellular Senescence ◽  
Weight Ratio ◽  
Mrna Levels ◽  
Body Weight Ratio ◽  
Chromosomal Stability

Background: Treatment with the chemotherapy drug doxorubicin (DOX) may lead to toxicities that affect non-cancer cells including the liver. Supplementing the diet with creatine (Cr) has been suggested as a potential intervention to minimize DOX-induced side effects, but its effect in alleviating DOX-induced hepatoxicity is currently unknown. Therefore, we aimed to examine the effects of Cr supplementation on DOX-induced liver damage. Methods: Male Sprague-Dawley rats were fed a diet supplemented with 2% Cr for four weeks, 4% Cr for one week followed by 2% Cr for three more weeks, or control diet for four weeks. Animals then received either a bolus i.p. injection of DOX (15 mg/kg) or saline as a placebo. Animals were then sacrificed five days-post injection and markers of hepatoxicity were analyzed using the liver-to-body weight ratio, aspartate transaminase (AST)-to- alanine aminotransferase (ALT) ratio, alkaline phosphatase (ALP), lipemia, and T-Bilirubin. In addition, hematoxylin and eosin (H&E) staining, Picro-Sirius Red staining, and immunofluorescence staining for CD45, 8-OHdG, and β-galactosidase were performed to evaluate liver morphology, fibrosis, inflammation, oxidative stress, and cellular senescence, respectively. The mRNA levels for biomarkers of liver fibrosis, inflammation, oxidative stress, and senescence-related genes were measured in liver tissues. Chromosomal stability was evaluated using global DNA methylation ELISA. Results: The ALT/AST ratio and liver to body weight ratio tended to increase in the DOX group, and Cr supplementation tended to attenuate this increase. Furthermore, elevated levels of liver fibrosis, inflammation, oxidative stress, and senescence were observed with DOX treatment, and Cr supplementation prior to DOX treatment ameliorated this hepatoxicity. Moreover, DOX treatment resulted in chromosomal instability (i.e., altered DNA methylation profile), and Cr supplementation showed a tendency to restore chromosomal stability with DOX treatment. Conclusion: The data suggest that Cr protected against DOX-induced hepatotoxicity by attenuating fibrosis, inflammation, oxidative stress, and senescence.

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