A retrospective naturalistic study on the psychopharmacological treatment of schizoaffective disorder

In spite of the beneficial effects of antipsychotics (AP) on the course of schizoaffective disorder (SAD) in general, there is an evidence for some negative aspects of their application. The objective of the study was to investigate the clinical manifestations and the course of resistant SAD while treated by the different AP. At present, the research includes 63 patients with SAD and duration of psychotic and/or affective symptoms more than six months. The research was naturalistic follow-up. The first group of patients (n = 18) were treated with SGA. An average duration of hospitalization was 61.2 days. After a reduction of acute psychotic condition, subthreshold psychotic and anxiety symptoms were still remaining. The total PANSS score was 71 ± 8. The second group (n = 24) was treated with a combination of FGA and SGA. An average duration of hospitalization was 53.8 days, the total PANSS score was 79 ± 6. It has been prevailed subthreshold bipolar symptoms. The third group of patients (n = 21) were treated with FGA. An average duration of hospitalization was 45.5 days; the total PANSS score was 63 ± 10. The negative symptoms and subthreshold depressions have been prevailed among the patients.To conclude, the treatment of SAD by the SGA and combination of SGA and FGA are more likely associated with persistence of subthreshold psychotic and/or bipolar disorder and the longer duration of hospitalizations. On the other hand, application of FGA in SAD is more likely associated with negative symptoms and depressions after a reduction of acute psychotic condition.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Interrelation of clinical-anamnestic, medical-biological and neurocognitive characteristics of maladaptation in remission as a component of pathopersonological transformations in patients with schizoaffective disorder

Ukrains'kyi Visnyk Psykhonevrolohii ◽

10.36927/20790325-v28-is1-2020-15 ◽

2020 ◽

pp. 68-74

Author(s):

Mykola Khomitskyi

Keyword(s):

Schizoaffective Disorder ◽

Pathological Process ◽

Psychotic Symptoms ◽

Neurocognitive Deficits ◽

Psychoactive Substances ◽

Psychopharmacological Treatment ◽

Icd 10 ◽

Rehabilitation Measures ◽

Neurological Pathology

The aim of the study was to study the interrelation between clinical, medical, biological and neurocognitive characteristics of maladaptation (as a component of pathopersonological transformations) in patients with schizoaffective disorder in remission. On the basis of the Regional Clinical Psychiatric Hospital (Zaporizhzhia, Ukraine) 102 persons with the established diagnosis of “schizoaffective disorder” were examined. Diagnosis was per formed according to the International ICD-10. The mandatory criteria for inclusion in the study were the presence of a condition of clinical remission with reduction of psychotic symptoms and the absence of severe somatic and neurological pathology, abuse of psychoactive substances. The main methods of the study were clinical psychopathological, psychodiagnostical, clinical-anamnestic and clinical-cathamnestic as well as medi cal and statistical analysis. The study established the presence and regularities of conjugation of clinical, medical, biological, and neurocognitive characteristics of maladaptation (as a component of pathopersonological transformations) in patients with schizoaffective disorder in remission. The structure of neurocognitive deficits in schizoaffective disorder in remission is related to the clinical type of the disease, the sex, the duration of the pathological process, and the characteristics of psychopharmacological treatment. The established regularities emphasize the importance of neurocognitive disorders in the structure of pathopersonological transformations and can be used in the formation of the system of diagnostic and treatment and rehabilitation measures to improve the quality of differential diagnosis and to carry out preventive and therapeutic rehabilitation measures to reduce the level of social maladaptation of patients with schizoaffective disorder. Keywords: schizoaffective disorder, clinic, neurocognition, social maladaptation, pathopersonalogical transformations

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