Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias

2015 ◽  
Vol 25 (3) ◽  
pp. 99-105 ◽  
Author(s):  
Janna N. Vrijsen ◽  
Susanne Vogel ◽  
Alejandro Arias-Vásquez ◽  
Barbara Franke ◽  
Guillén Fernández ◽  
...  
Keyword(s):  
Childhood Trauma ◽  
Mineralocorticoid Receptor ◽  
Memory Bias ◽  
Depressed Patients ◽  
Negative Memory

scholarly journals Childhood trauma and negative memory bias as shared risk factors for psychopathology and comorbidity in a naturalistic psychiatric patient sample

2018 ◽  
Vol 8 (12) ◽  
pp. e01181 ◽  
Author(s):  
Janna N. Vrijsen ◽  
Camiel T. van Amen ◽  
Bauke Koekkoek ◽  
Iris van Oostrom ◽  
Aart H. Schene ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Trauma ◽  
Psychiatric Patient ◽  
Memory Bias ◽  
Patient Sample ◽  
Negative Memory ◽  
Shared Risk

scholarly journals Childhood trauma and negative memory bias as shared risk factors for psychopathology and comorbidity in a naturalistic psychiatric patient sample

2017 ◽  
Vol 7 (6) ◽  
pp. e00693 ◽  
Author(s):  
Janna N. Vrijsen ◽  
Camiel T. van Amen ◽  
Bauke Koekkoek ◽  
Iris van Oostrom ◽  
Aart H. Schene ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Trauma ◽  
Psychiatric Patient ◽  
Memory Bias ◽  
Patient Sample ◽  
Negative Memory ◽  
Shared Risk

Linking genetic variants of the mineralocorticoid receptor and negative memory bias: Interaction with prior life adversity

2014 ◽  
Vol 40 ◽  
pp. 181-190 ◽  
Author(s):  
Susanne Vogel ◽  
Lotte Gerritsen ◽  
Iris van Oostrom ◽  
Alejandro Arias-Vásquez ◽  
Mark Rijpkema ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Mineralocorticoid Receptor ◽  
Memory Bias ◽  
Negative Memory

Depression, self-focused attention, and the negative memory bias.

1989 ◽  
Vol 57 (2) ◽  
pp. 351-357 ◽  
Author(s):  
Tom Pyszczynski ◽  
James C. Hamilton ◽  
Fred H. Herring ◽  
Jeff Greenberg
Keyword(s):  
Memory Bias ◽  
Focused Attention ◽  
Negative Memory

Effects of mineralocorticoid receptor and NMDA receptor stimulation on empathy in depressed patients and healthy individuals

2019 ◽  
Vol 107 ◽  
pp. 23-24
Author(s):  
Jan Nowacki ◽  
Michael Kaczmarczyk ◽  
Woo Ri Chae ◽  
Katja Wingenfeld ◽  
Christian Otte
Keyword(s):  
Nmda Receptor ◽  
Mineralocorticoid Receptor ◽  
Healthy Individuals ◽  
Receptor Stimulation ◽  
Depressed Patients

Abnormal brain activation during directed forgetting of negative memory in depressed patients

2016 ◽  
Vol 190 ◽  
pp. 880-888 ◽  
Author(s):  
Wenjing Yang ◽  
Qunlin Chen ◽  
Peiduo Liu ◽  
Hongsheng Cheng ◽  
Qian Cui ◽  
...  
Keyword(s):  
Brain Activation ◽  
Directed Forgetting ◽  
Depressed Patients ◽  
Negative Memory ◽  
Abnormal Brain

scholarly journals The BDNF Val66Met polymorphism affects negative memory bias in civilian women with PTSD

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hiroaki Hori ◽  
Mariko Itoh ◽  
Fuyuko Yoshida ◽  
Mingming Lin ◽  
Madoka Niwa ◽  
...  
Keyword(s):  
Memory Bias ◽  
Val66met Polymorphism ◽  
Negative Memory ◽  
Bdnf Val66met Polymorphism ◽  
Civilian Women

scholarly journals No Evidence for the Association between a Polymorphism in the PCLO Depression Candidate Gene with Memory Bias in Remitted Depressed Patients and Healthy Individuals

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112153
Author(s):  
Janna N. Vrijsen ◽  
Anne Speckens ◽  
Alejandro Arias-Vásquez ◽  
Barbara Franke ◽  
Eni S. Becker ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Memory Bias ◽  
Healthy Individuals ◽  
Depressed Patients ◽  
With Memory

Assessment of the hypothalamic–pituitary–adrenal axis activity: glucocorticoid receptor and mineralocorticoid receptor function in depression with early life stress – a systematic review

2012 ◽  
Vol 24 (1) ◽  
pp. 4-15 ◽  
Author(s):  
Cristiane Von Werne Baes ◽  
Sandra M. de Carvalho Tofoli ◽  
Camila Maria S. Martins ◽  
Mario F. Juruena
Keyword(s):  
Systematic Review ◽  
Glucocorticoid Receptor ◽  
Hpa Axis ◽  
Life Stress ◽  
Early Life ◽  
Mineralocorticoid Receptor ◽  
Early Life Stress ◽  
Hypothalamic Pituitary Adrenal ◽  
Depressed Patients ◽  
Suppression Test

Objective:The mechanisms involved in the dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, especially in the functioning of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in depressed patients, are not well elucidated. The objective of this study was to conduct a systematic review of articles that assess the HPA axis activity from GR and MR in depressed patients and healthy controls with or without early life stress.Methods:We conducted a systematic review of articles in PubMed, SCOPUS and SciELO published between 2000 and 2011, using the following search terms:child abuse,depression,HPA axis,dexamethasone,prednisolone,fludrocortisoneandspironolactone. Thirty-four papers were selected for this review.Results:Most studies identified in this review used the dexamethasone/corticotropin-releasing hormone test and dexamethasone suppression test. In these studies, hypercortisolaemia was associated with depression. We identified three studies with the Prednisolone suppression test, only one study with the use of fludrocortisone and one with spironolactone. This review found nine studies that evaluated the HPA axis in individuals with early life stress.Conclusions:The majority of the studies assessed in this review show that early life stress leads to permanent changes in the HPA axis and may lead to development of depression in adults. The most consistent findings in the literature show increased activity of the HPA axis in depression associated with hypercortisolaemia and reduced inhibitory feedback. These findings suggest that this dysregulation of the HPA axis is partially attributable to an imbalance between GR and MR. Evidences have consistently showed that GR function is impaired in major depression, but few studies have assessed the activity of MR in depression and early life stress.

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