scholarly journals Travelling-wave analysis of a model of tumour invasion with degenerate, cross-dependent diffusion

2021 ◽  
Vol 477 (2256) ◽  
Author(s):  
Chloé Colson ◽  
Faustino Sánchez-Garduño ◽  
Helen M. Byrne ◽  
Philip K. Maini ◽  
Tommaso Lorenzi
Keyword(s):  
Wave Solution ◽  
Degradation Rate ◽  
Wave Speed ◽  
Propagation Speed ◽  
Travelling Wave ◽  
Travelling Wave Solution ◽  
Tumour Invasion ◽  
Wave Analysis ◽  
Shooting Argument ◽  
Minimal Wave Speed

In this paper, we carry out a travelling-wave analysis of a model of tumour invasion with degenerate, cross-dependent diffusion. We consider two types of invasive fronts of tumour tissue into extracellular matrix (ECM), which represents healthy tissue. These types differ according to whether the density of ECM far ahead of the wave front is maximal or not. In the former case, we use a shooting argument to prove that there exists a unique travelling-wave solution for any positive propagation speed. In the latter case, we further develop this argument to prove that there exists a unique travelling-wave solution for any propagation speed greater than or equal to a strictly positive minimal wave speed. Using a combination of analytical and numerical results, we conjecture that the minimal wave speed depends monotonically on the degradation rate of ECM by tumour cells and the ECM density far ahead of the front.

scholarly journals Response of Immunotherapy to Tumour-TICLs Interactions: A Travelling Wave Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Joseph Malinzi ◽  
Precious Sibanda ◽  
Hermane Mambili-Mamboundou
Keyword(s):  
Phase Space ◽  
Mathematical Modelling ◽  
Wave Speed ◽  
Interaction Model ◽  
Travelling Wave ◽  
Tumour Invasion ◽  
Wave Analysis ◽  
Stable And Unstable Manifolds ◽  
Minimum Wave Speed ◽  
Unstable Manifolds

There are several cancers for which effective treatment has not yet been identified. Mathematical modelling can nevertheless point out to clinicians tumour invasion properties that should be targeted to mitigate these cancers. We present a travelling wave analysis of a tumour-immune interaction model with immunotherapy. We use the geometric treatment of an apt-phase space to establish the intersection between stable and unstable manifolds. We calculate the minimum wave speed and numerical simulations are performed to support the analytical results.

Travelling wave solutions of a parabolic-hyperbolic system for contact inhibition of cell-growth

2015 ◽  
Vol 26 (3) ◽  
pp. 297-323 ◽  
Author(s):  
M. BERTSCH ◽  
D. HILHORST ◽  
H. IZUHARA ◽  
M. MIMURA ◽  
T. WAKASA
Keyword(s):  
Partial Differential Equations ◽  
Cell Growth ◽  
Large Class ◽  
Wave Solution ◽  
Wave Speed ◽  
Large Time ◽  
Travelling Wave ◽  
Travelling Wave Solution ◽  
Travelling Wave Solutions ◽  
Wave Solutions

We consider a cell growth model involving a nonlinear system of partial differential equations which describes the growth of two types of cell populations with contact inhibition. Numerical experiments show that there is a parameter regime where, for a large class of initial data, the large time behaviour of the solutions is described by a segregated travelling wave solution with positive wave speed c. Here, the word segregated expresses the fact that the different types of cells are spatially segregated, and that the single densities are discontinuous at the moving interface which separates the two populations. In this paper, we show that, for each wave speed c > c, there exists an overlapping travelling wave solution, whose profile is continuous and no longer segregated. We also show that, for a large class of initial functions, the overlapping travelling wave solutions cannot represent the large time profile of the solutions of the system of partial differential equations. The structure of the travelling wave solutions strongly resembles that of the scalar Fisher-KPP equation, for which the special role played by the travelling wave solution with minimal speed has been extensively studied.

scholarly journals EVOLUTION OF MODULATIONAL INSTABILITY IN TRAVELLING WAVE SOLUTION OF NON-LINEAR PARTIAL DIFFERENTIAL EQUATION

2020 ◽  
Vol 5 (1) ◽  
pp. 1-7
Author(s):  
Ram Dayal Pankaj ◽  
Arun Kumar ◽  
Chandrawati Sindhi
Keyword(s):  
Differential Equation ◽  
Partial Differential Equation ◽  
Wave Solution ◽  
Modulational Instability ◽  
Nonlinear Partial Differential Equation ◽  
Linear Partial Differential Equation ◽  
Travelling Wave ◽  
Travelling Wave Solution ◽  
Partial Differential ◽  
Jacobian Elliptic Functions

The Ritz variational method has been applied to the nonlinear partial differential equation to construct a model for travelling wave solution. The spatially periodic trial function was chosen in the form of combination of Jacobian Elliptic functions, with the dependence of its parameters

scholarly journals Travelling Waves of a Diffusive Epidemic Model with Latency and Relapse

2013 ◽  
Vol 2013 ◽  
pp. 1-13
Author(s):  
Zhiping Wang ◽  
Rui Xu
Keyword(s):  
Fixed Point ◽  
Fixed Point Theorem ◽  
Epidemic Model ◽  
Wave Solution ◽  
Local Stability ◽  
Travelling Waves ◽  
Upper And Lower Solutions ◽  
Travelling Wave ◽  
Spatial Diffusion ◽  
Travelling Wave Solution

An SEIR epidemic model with relapse and spatial diffusion is studied. By analyzing the corresponding characteristic equations, the local stability of each of the feasible steady states to this model is discussed. The existence of a travelling wave solution is established by using the technique of upper and lower solutions and Schauder's fixed point theorem. Numerical simulations are carried out to illustrate the main results.

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