Non–invasive measurements of breast tissue optical properties using frequency–domain photon migration

A multiwavelength, high bandwidth (1 GHz) frequency–domain photon migration (FDPM) instrument has been developed for quantitative, non–invasive measurements of tissue optical and physiological properties. The instrument produces 300 kHz to 1 GHz photon density waves (PDWs) in optically turbid media using a network analyser, an avalanche photodiode detector and four amplitude–modulated diode lasers (674 nm, 811 nm, 849 nm and 956 nm). The frequency–dependence of PDW phase and amplitude is measured and compared to analytically derived model functions in order to calculate absorption, μ a , and reduced scattering, μ ′ s , parameters. The wavelength–dependence of absorption is used to determine tissue haemoglobin concentration (total, oxy– and deoxy– forms), oxygen saturation and water concentration. We present preliminary results of non–invasive FDPM measurements obtained from normal and tumour–containing human breast tissue. Our data clearly demonstrate that physiological changes caused by the presence of small (about 1 cm diameter) palpable lesions can be detected using a handheld FDPM probe.

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Multi-Distance Frequency-Domain Optical Measurements of Coherent Cerebral Hemodynamics

Photonics ◽

10.3390/photonics6030083 ◽

2019 ◽

Vol 6 (3) ◽

pp. 83 ◽

Cited By ~ 7

Author(s):

Giles Blaney ◽

Angelo Sassaroli ◽

Thao Pham ◽

Nishanth Krishnamurthy ◽

Sergio Fantini

Keyword(s):

Frequency Domain ◽

Phase Difference ◽

Near Infrared ◽

Amplitude Ratio ◽

Human Subjects ◽

Optical Measurements ◽

Photon Density ◽

Healthy Human ◽

Non Invasive ◽

Photon Density Waves

We report non-invasive, bilateral optical measurements on the forehead of five healthy human subjects, of 0.1 Hz oscillatory hemodynamics elicited either by cyclic inflation of pneumatic thigh cuffs, or by paced breathing. Optical intensity and the phase of photon-density waves were collected with frequency-domain near-infrared spectroscopy at seven source-detector distances (11–40 mm). Coherent hemodynamic oscillations are represented by phasors of oxyhemoglobin (O) and deoxyhemoglobin (D) concentrations, and by the vector D/O that represents the amplitude ratio and phase difference of D and O. We found that, on an average, the amplitude ratio (|D/O|) and the phase difference (∠(D/O)) obtained with single-distance intensity at 11–40 mm increase from 0.1° and −330° to 0.2° and −200°, respectively. Single-distance phase and the intensity slope featured a weaker dependence on source-detector separation, and yielded |D/O| and ∠(D/O) values of about 0.5 and −200°, respectively, at distances greater than 20 mm. The key findings are: (1) Single-distance phase and intensity slope are sensitive to deeper tissue compared to single-distance intensity; (2) deeper tissue hemodynamic oscillations, which more closely represent the brain, feature D and O phasors that are consistent with a greater relative flow-to-volume contributions in brain tissue compared to extracerebral, superficial tissue.

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NON-INVASIVE HEMODYNAMIC MONITORING USING NEAR INFRARED FREQUENCY DOMAIN PHOTON MIGRATION IN RABBIT HEMORRHAGIC SHOCK MODEL.

Journal of Investigative Medicine ◽

10.1097/00042871-200305000-00035 ◽

2003 ◽

Vol 51 (3) ◽

pp. 171

Author(s):

N. M. Hanna ◽

R. Mina-Araghi ◽

J. Lee ◽

A. Cerussi ◽

H. Poggemeyer ◽

...

Keyword(s):

Hemorrhagic Shock ◽

Frequency Domain ◽

Hemodynamic Monitoring ◽

Near Infrared ◽

Photon Migration ◽

Shock Model ◽

Non Invasive ◽

Invasive Hemodynamic Monitoring ◽

Hemorrhagic Shock Model

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A compact and non-invasive tissue cancer detectors based on frequency-domain photon migration

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) ◽

10.1109/isbb.2014.6820919 ◽

2014 ◽

Author(s):

Po-An Chen ◽

Chin-Lung Yang ◽

Sheng-Hao Tseng ◽

Ming-Wei Li

Keyword(s):

Frequency Domain ◽

Photon Migration ◽

Non Invasive ◽

Tissue Cancer

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Detection and characterization of breast tumours by time-domain scanning optical mammography

Opto-Electronics Review ◽

10.2478/s11772-008-0004-5 ◽

2008 ◽

Vol 16 (2) ◽

Cited By ~ 23

Author(s):

H. Rinneberg ◽

D. Grosenick ◽

K. Moesta ◽

H. Wabnitz ◽

J. Mucke ◽

...

Keyword(s):

Indocyanine Green ◽

Time Domain ◽

Breast Tissue ◽

Photon Density ◽

Optical Mammography ◽

Scanning Time ◽

Model Following ◽

Number Of Patients ◽

Photon Density Waves ◽

Qualitative Measure

AbstractThe paper gives a short overview of various methods of optical mammography, emphasizing scanning time-domain mammography. The results of a clinical study on time-domain optical mammography are reviewed, comprising 154 patients carrying a total of 102 carcinomas validated by histology. A visibility score attributed to each carcinoma as qualitative measure of tumour detectability indicates acceptable sensitivity but poor specificity for discrimination between malignant and benign lesions. Likewise, a multi-variate statistical analysis yields sensitivity and specificity between 80% and 85% for tumour detection and discrimination with respect to normal (healthy) breast tissue, but values less than 70% for discrimination between malignant and benign breast lesions, being too low to be of clinical relevance. For 87 of the 88 tumours detected retrospectively in both projection optical mammograms, optical properties and tissue parameters were derived based on the diffraction of photon density waves by a spherical inhomogeneity as forward model. Following injection of a bolus of indocyanine green as non-targeted absorbing contrast agent, dynamic contrast-enhanced time-domain optical mammography was carried out on a small number of patients, but no differences in wash-out kinetics of indocyanine green between tumours and healthy breast tissue were observed.

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