scholarly journals Comparison of ultracentrifugation and polyethylene glycol precipitation for concentration of hepatitis B virus (HBV) DNA for molecular hybridisation tests and the relationship of HBV-DNA to HBe antigen and anti-HBe status

1991 ◽  
Vol 35 (5) ◽  
pp. 291-293 ◽  
Author(s):  
D. SANYAL ◽  
G. KUDESIA ◽  
G. CORBITT
Keyword(s):  
Polyethylene Glycol ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Dna ◽  
Hbe Antigen ◽  
B Virus ◽  
Polyethylene Glycol Precipitation ◽  
Relationship Of ◽  
The Relationship

A Study on the Relationship of Hepatitis B Virus with Hepatocellular Carcinoma

2014 ◽  
Vol 9 (5) ◽  
pp. 53-58
Author(s):  
Ochei Kingsley Chinedum ◽  
◽  
Obeagu Emmanuel Ifeanyi ◽  
Uzoije Nwandikor U ◽  
Onyenweaku Florence
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
B Virus ◽  
Relationship Of ◽  
The Relationship

scholarly journals The Relationship between Intrahepatic Distribution of Hepatitis B Virus Core Antigen and Serum ALT, HBV DNA Levels and HBeAg Status

2012 ◽  
Vol 1 (2) ◽  
pp. 84-90 ◽  
Author(s):  
Qing He ◽  
Qi-yuan Tang ◽  
Xiao-hua Le ◽  
De-liang Lv ◽  
Xiang-mei Zhang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Dna ◽  
Inflammatory Activity ◽  
Activity Score ◽  
Core Antigen ◽  
B Virus ◽  
Normal Alt ◽  
The Relationship ◽  
Hbeag Status

Abstract Objective The clinical significance of differential distribution of hepatitis B virus (HBV) nucleocapsid antigen in hepatocytes remains unknown. The goal of this study is to determine the relationship between distinct HBV core antigen distribution pattern and alanine transaminase (ALT), liver histological inflammatory activity grades, serum HBeAg status and HBV DNA level.Methods Total of 958 cases with chronic hepatitis B were recruited into this study. Liver function tests, serum HBV DNA level, serological HBV markers and liver immunohistochemistry were examined according to the conventional instructions. Chi Square tests were performed to analyze the differences among these groups.Results It was found that 552 (58%) cases were tested positive for HBV core antigen by immunohistochemical staining. Cytoplasmic hepatitis B core antigen (HBcAg) expression correlated with ALT level and serum HBV DNA and liver inflammatory activity scores, however, nuclear HBcAg expression in hepatocytes was associated with normal ALT level, lower liver inflammatory activity score and higher serum HBV DNA level and rate of HBeAg positivity. Both nuclear and cytoplasmic HBcAg expression in hepatocytes associated with a middle ALT level and liver inflammatory activity score, higher rate of serum detectable HBeAg and a higher HBV DNA level. However, undetectable core antigen was related to a lower ALT level and histological inflammatory activity grade, lower positive HBeAg rate and HBV DNA level.Conclusions Undetectable liver HBcAg is associated with HBV clearance, ALT normalization and hepatitis B e antigen (HBeAg) seroconversion, and cytoplasmic HBcAg expression associated with higher hepatic inflammatory activity. However, nuclear HBcAg expression correlates with immune tolerance characterized with normal ALT and lower liver inflammatory activity, higher HBV replication level and higher rate of HBeAg positivity.

The relationship of hepatitis B virus infection between adults and their children in Guangxi Province, China

2000 ◽  
Vol 33 (4) ◽  
pp. 628-631 ◽  
Author(s):  
Jiatong Zhuo ◽  
Guoyu Tao ◽  
Shahul H. Ebrahim ◽  
Shusheng Wang ◽  
Zhongbin Luo ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Guangxi Province ◽  
B Virus ◽  
Relationship Of ◽  
The Relationship

The relationship of hepatitis B virus infection between adults and their children in Guangxi Province, China

2000 ◽  
Vol 33 (4) ◽  
pp. 628-631 ◽  
Author(s):  
Jiatong Zhuo ◽  
Guoyu Tao ◽  
Shahul H Ebrahim ◽  
Shusheng Wang ◽  
Zhongbin Luo ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Guangxi Province ◽  
B Virus ◽  
Relationship Of ◽  
The Relationship

scholarly journals Potential risk factors for the reactivation of the replication of hepatitis B viruses after transcatheter arterial chemoembolization of hepatocellular carcinoma: a retrospective analysis

2020 ◽  
Author(s):  
Xiaoguang Wang ◽  
Xiaodan Yang ◽  
Haitao Yu ◽  
Zhengwei Song ◽  
Fei Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Survival Rates ◽  
Hbv Dna ◽  
Hbv Reactivation ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus ◽  
The Relationship

Abstract Objective: To investigate the clinical features of hepatitis B virus(HBV) reactivation after transcatheter arteriaI chemoembolization (TACE) treatment in patients with hepatocellular carcinoma (HCC), and analyze the relationship between hepatitis B virus reactivation and clinicopathological factors and prognosis. Methods: Clinical data of 108 patients with HCC treated by TACE from January 2006 to January 2014 were retrospectively studied. The relationship between the clinical data and HBV reactivation were analyzed and the differences in survival rates between the reactivation group and the non-reactivation group were also compared. Results: 42 (38.9%) patients developed HBV reactivation. The reactivation rate in patients with HBV DNA ≥ 104 was 65.8% (25/38), and was much higher than that of the patients with HBV DNA < 104 (24.3%, 17/70). The cellular immune function of reactivation group was significantly lower than that of non-reactivation group(P < 0.01). There was a significant difference (P=0.03) in 2-year survival rate between the activated and non-activated groups, and their survival rates were 35.9% and 53.3%, respectively. Conclusion: Some patients with primary hepatocellular carcinoma may have hepatitis B virus reactivation after receiving TACE treatment, and positive HBV DNA, immunosuppression were the risk factors for the development of HBV reactivation. Patients with hepatitis B virus reactivation after TACE have poor prognosis. The study suggests that antiviral therapy and immunoenhancer were necessary to improve curative effect and survival rate in HCC patients who underwent TACE.

scholarly journals Association between maternal hepatitis B virus carrier and gestational diabetes mellitus: a retrospective cohort analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Wanchang Yin ◽  
Bingjun Chen ◽  
Yilin Yang ◽  
Xiuzi Li ◽  
Ruirui Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Viral Load ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Hbv Dna ◽  
Hbsag Carrier ◽  
B Virus ◽  
The Relationship

Abstract Introduction Given that many pregnant women have chronic hepatitis B virus (HBV) infection and that gestational diabetes mellitus (GDM) is linked to poor maternal and neonatal outcomes, we looked into the relationship between the hepatitis B surface antigen (HBsAg) and GDM to see if a high HBV DNA load is linked to a higher risk of GDM in chronic maternal HBsAg carriers. Materials and methods Our study included 39,539 pregnant women who gave birth at the Third Affiliated Hospital of Guangzhou Medical University in Guangzhou, China, between January 1, 2009, and December 31, 2019. The patients were divided into two groups: HBsAg negative (36,500) and positive (3039). The viral load levels of 1250 HBsAg-positive women who had tested their HBV DNA load during pregnancy were separated into three groups. We utilized univariate and multivariable logistical regression analysis to determine the relationship between maternal chronic HBsAg carrier and GDM. Results Being HBsAg positive was discovered to be an independent risk factor for GDM.Pre-pregnancy Obesity and advanced age were linked to an increased incidence of GDM. Those with a high HBV DNA load (> 106 IU/mL) had a higher risk of GDM than HBsAg-positive women with a low viral load (< 103 IU/mL). Pre-eclampsia and intrahepatic cholestasis of pregnancy (ICP) appeared to be more common in HBsAg-positive women than in uninfected women. Conclusions Being HBsAg positive, advanced age, and pre-pregnancy obesity were all revealed to be independent risk factors for GDM in our study. In HBsAg carrier, pregnant women, a high HBV DNA burden was linked to a greater risk of GDM. Furthermore, being an HBsAg carrier during pregnancy raised the risk of ICP and pre-eclampsia.

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