scholarly journals Monomicrobial necrotizing fasciitis in a white male caused by hypermucoviscous Klebsiella pneumoniae

2009 ◽  
Vol 58 (11) ◽  
pp. 1519-1521 ◽  
Author(s):  
Gudjon L. Gunnarsson ◽  
Pernille B. Brandt ◽  
Dorte Gad ◽  
Carsten Struve ◽  
Ulrik S. Justesen
Keyword(s):  
Klebsiella Pneumoniae ◽  
Necrotizing Fasciitis ◽  
Liver Abscess ◽  
Virulence Factors ◽  
White Male ◽  
First Report ◽  
Highly Virulent

We report a case of monomicrobial necrotizing fasciitis caused by hypermucoviscous Klebsiella pneumoniae in an immunocompromised white male after travel to China. The K. pneumoniae isolate belonged to the K2 serotype, and carried the virulence factors RmpA and aerobactin. To the best of our knowledge this is the first report of necrotizing fasciitis caused by hypermucoviscous K. pneumoniae resembling the highly virulent K. pneumoniae isolates associated with liver abscess syndrome in Asia.

First Report of Cryptogenic Klebsiella Pneumoniae Liver Abscess in Pregnancy [17I]

2018 ◽  
Vol 131 ◽  
pp. 102S
Author(s):  
Stacey Stevens Schmiedecke ◽  
Sarah Estrada ◽  
Peter Napolitano
Keyword(s):  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
First Report ◽  
In Pregnancy

scholarly journals Virulence Factors and Molecular Epidemiology of Pyogenic Liver Abscess Causing Multidrug Resistant Klebsiella pneumoniae in Wenzhou, China

2020 ◽  
Author(s):  
Zhongyong Wang ◽  
Siqin Zhang ◽  
Na Huang ◽  
Shixing Liu ◽  
Ye Xu ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Epidemiology ◽  
Liver Abscess ◽  
Virulence Factors ◽  
Growth Curves ◽  
Pyogenic Liver Abscess ◽  
Multidrug Resistant ◽  
Infection Model ◽  
Tertiary Teaching ◽  
String Test

Abstract Background: To date, little is known about virulence characteristics of pyogenic liver abscess (PLA) causing multidrug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae). It may be that these strains are rare. The aim of this study was to analyze the virulence characteristics and molecular epidemiology of 12 MDR strains from 163 PLA cases in a tertiary teaching hospital from the perspective of clinical characteristics, virulence phenotypes and genotypes.Results: The virulence phenotypes of the 12 PLA-causing MDR K. pneumoniae were similar or even more obvious than those of typical hypervirulent Klebsiella pneumoniae control strains according to the results of growth curves, string test, capsular quantification, serum killing test, biofilm formation assay, and infection model. These MDR strains were mainly non-K1/K2 serotypes and carried multiple virulence genes. Multilocus sequence typing (MLST) illustrated that the MDR strains were categorized into nine sequence types.Conclusions: This study is the first analysis of the virulence factors in PLA-causing MDR strains. Our data exhibited the coexistence of hypervirulence and multidrug resistance in PLA-causing MDR K. pneumoniae strains, and the clones of those PLA-causing MDR strains were diverse and scattered. The study was firstly found one ST11 carbapenem-resistant hypervirulent strain in PLA.

scholarly journals First Case of Liver Abscess in Scandinavia Due to the International Hypervirulent Klebsiella Pneumoniae Clone ST23

2014 ◽  
Vol 8 (1) ◽  
pp. 22-24 ◽  
Author(s):  
Svend Gundestrup ◽  
Carsten Struve ◽  
Steen G. Stahlhut ◽  
Dennis SchrØder Hansen
Keyword(s):  
Case Report ◽  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Virulence Factors ◽  
Pyogenic Liver Abscess ◽  
Predisposing Factors ◽  
Foreign Travel ◽  
First Case ◽  
History Of

This is the first case report from Scandinavia of a pyogenic liver abscess caused by a Klebsiella pneumoniae isolate belonging to the international hyper virulent clone ST23. The patient, an 85-year old Caucasian, had no history of foreign travel or any classical predisposing factors for infection. The isolate was hypermucoviscous of capsular serotype K1 and carried the virulence factors aerobactin, allS, kfu and rmpA.

scholarly journals Virulence Factors and Molecular Epidemiology of Pyogenic Liver Abscess Causing Multidrug Resistant Klebsiella pneumoniae in Wenzhou, China

2020 ◽  
Author(s):  
Zhongyong Wang ◽  
Siqin Zhang ◽  
Na Huang ◽  
Shixing Liu ◽  
Ye Xu ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Epidemiology ◽  
Liver Abscess ◽  
Virulence Factors ◽  
Virulence Genes ◽  
Pyogenic Liver Abscess ◽  
Multidrug Resistant ◽  
Carbapenem Resistant ◽  
Tertiary Teaching ◽  
Tertiary Teaching Hospital

Abstract Background: To date, little is known about virulence characteristics of pyogenic liver abscess (PLA) causing multidrug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae). It may be these strains are rare. The aim of this study was to analyze the virulence and molecular epidemiology of 12 MDR strains from 163 PLA cases in a tertiary teaching hospital from the perspective of clinical characteristics, virulence phenotypes and genotypes.Results: The virulence phenotypes of the twelve PLA-causing MDR K. pneumoniae were similar or even more obvious than those of sensitive hypervirulent Klebsiella pneumoniae control strains. These MDR strains were mainly non-K1/K2 serotypes and carried multiple virulence genes. Multilocus sequence typing (MLST) revealed the PLA-causing MDR strains had low clone correlation.Conclusions: This study was the first analysis on virulence factors of PLA-causing MDR strains. The virulent factors exhibited the coexistence of hypervirulence and multidrug resistance in PLA-causing MDR K. pneumoniae strains, and these MDR strains were mainly polyclonal spread and there was firstly found one ST11 carbapenem-resistant hypervirulent strain in PLA.

scholarly journals Necrotizing Fasciitis Associated with Klebsiella pneumoniae Liver Abscess

1999 ◽  
Vol 29 (5) ◽  
pp. 1360-1361 ◽  
Author(s):  
B.-S. Hu ◽  
Y.-J. Lau ◽  
Z.-Y. Shi ◽  
Y.-H. Lin
Keyword(s):  
Klebsiella Pneumoniae ◽  
Necrotizing Fasciitis ◽  
Liver Abscess
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