scholarly journals First Case of Liver Abscess in Scandinavia Due to the International Hypervirulent Klebsiella Pneumoniae Clone ST23

2014 ◽  
Vol 8 (1) ◽  
pp. 22-24 ◽  
Author(s):  
Svend Gundestrup ◽  
Carsten Struve ◽  
Steen G. Stahlhut ◽  
Dennis SchrØder Hansen
Keyword(s):  
Case Report ◽  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Virulence Factors ◽  
Pyogenic Liver Abscess ◽  
Predisposing Factors ◽  
Foreign Travel ◽  
First Case ◽  
History Of

This is the first case report from Scandinavia of a pyogenic liver abscess caused by a Klebsiella pneumoniae isolate belonging to the international hyper virulent clone ST23. The patient, an 85-year old Caucasian, had no history of foreign travel or any classical predisposing factors for infection. The isolate was hypermucoviscous of capsular serotype K1 and carried the virulence factors aerobactin, allS, kfu and rmpA.

scholarly journals A case report of pyogenic liver abscess caused by hypervirulent Klebsiella pneumoniae diagnosed by metagenomic next-generation sequencing

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110327
Author(s):  
Jiafeng Xie ◽  
Zhiqiang Zhu
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess ◽  
Next Generation ◽  
Drainage Fluid ◽  
String Test ◽  
History Of ◽  
Generation Sequencing

A 56-year-old woman with a history of diabetes mellitus presented with high fever but no abdominal pain. An abdominal computed tomography scan showed a large liver abscess. Hypervirulent, string test-positive, rmpA/ ampA2-, and iutA-positive Klebsiella pneumoniae was rapidly identified from drainage fluid of the liver abscess using metagenomic next-generation sequencing (mNGS). After intravenous antibiotic therapy and drainage of the abscess, the patient’s condition resolved. This case report highlights the value of mNGS in rapidly and accurately identifying a pathogenic microorganism, which helps reduce the incidence of antimicrobial resistance and enables the targeted use of antibiotics.

scholarly journals Virulence Factors and Molecular Epidemiology of Pyogenic Liver Abscess Causing Multidrug Resistant Klebsiella pneumoniae in Wenzhou, China

2020 ◽  
Author(s):  
Zhongyong Wang ◽  
Siqin Zhang ◽  
Na Huang ◽  
Shixing Liu ◽  
Ye Xu ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Epidemiology ◽  
Liver Abscess ◽  
Virulence Factors ◽  
Growth Curves ◽  
Pyogenic Liver Abscess ◽  
Multidrug Resistant ◽  
Infection Model ◽  
Tertiary Teaching ◽  
String Test

Abstract Background: To date, little is known about virulence characteristics of pyogenic liver abscess (PLA) causing multidrug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae). It may be that these strains are rare. The aim of this study was to analyze the virulence characteristics and molecular epidemiology of 12 MDR strains from 163 PLA cases in a tertiary teaching hospital from the perspective of clinical characteristics, virulence phenotypes and genotypes.Results: The virulence phenotypes of the 12 PLA-causing MDR K. pneumoniae were similar or even more obvious than those of typical hypervirulent Klebsiella pneumoniae control strains according to the results of growth curves, string test, capsular quantification, serum killing test, biofilm formation assay, and infection model. These MDR strains were mainly non-K1/K2 serotypes and carried multiple virulence genes. Multilocus sequence typing (MLST) illustrated that the MDR strains were categorized into nine sequence types.Conclusions: This study is the first analysis of the virulence factors in PLA-causing MDR strains. Our data exhibited the coexistence of hypervirulence and multidrug resistance in PLA-causing MDR K. pneumoniae strains, and the clones of those PLA-causing MDR strains were diverse and scattered. The study was firstly found one ST11 carbapenem-resistant hypervirulent strain in PLA.

scholarly journals Virulence Factors and Molecular Epidemiology of Pyogenic Liver Abscess Causing Multidrug Resistant Klebsiella pneumoniae in Wenzhou, China

2020 ◽  
Author(s):  
Zhongyong Wang ◽  
Siqin Zhang ◽  
Na Huang ◽  
Shixing Liu ◽  
Ye Xu ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Epidemiology ◽  
Liver Abscess ◽  
Virulence Factors ◽  
Virulence Genes ◽  
Pyogenic Liver Abscess ◽  
Multidrug Resistant ◽  
Carbapenem Resistant ◽  
Tertiary Teaching ◽  
Tertiary Teaching Hospital

Abstract Background: To date, little is known about virulence characteristics of pyogenic liver abscess (PLA) causing multidrug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae). It may be these strains are rare. The aim of this study was to analyze the virulence and molecular epidemiology of 12 MDR strains from 163 PLA cases in a tertiary teaching hospital from the perspective of clinical characteristics, virulence phenotypes and genotypes.Results: The virulence phenotypes of the twelve PLA-causing MDR K. pneumoniae were similar or even more obvious than those of sensitive hypervirulent Klebsiella pneumoniae control strains. These MDR strains were mainly non-K1/K2 serotypes and carried multiple virulence genes. Multilocus sequence typing (MLST) revealed the PLA-causing MDR strains had low clone correlation.Conclusions: This study was the first analysis on virulence factors of PLA-causing MDR strains. The virulent factors exhibited the coexistence of hypervirulence and multidrug resistance in PLA-causing MDR K. pneumoniae strains, and these MDR strains were mainly polyclonal spread and there was firstly found one ST11 carbapenem-resistant hypervirulent strain in PLA.

scholarly journals Pyogenic Liver Abscess and Endogenous Endophthalmitis Due to K64-ST1764 Hypervirulent Klebsiella pneumoniae: A Case Report

2021 ◽  
Vol Volume 14 ◽  
pp. 71-77
Author(s):  
Bo Zhao ◽  
Renjing Hu ◽  
Lei Gong ◽  
Xiaoyun Wang ◽  
Yingwei Zhu ◽  
...  
Keyword(s):  
Case Report ◽  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess ◽  
Endogenous Endophthalmitis

Case Report: Management of a Patient with mTBI and Vestibular Hypofunction with the Binasal Occlusion Technique

2018 ◽  
pp. 87-90
Keyword(s):  
Case Report ◽  
Visual Motion ◽  
Hand Movement ◽  
Motion Sensitivity ◽  
Vestibular Hypofunction ◽  
First Case ◽  
Neurological Exam ◽  
History Of ◽  
Occlusion Technique ◽  
Visual Vertigo

Background: Binasal Occlusion (BNO) is a clinical technique used by many neurorehabilitative optometrists in patients with mild traumatic brain injury (mTBI) and increased visual motion sensitivity (VMS) or visual vertigo. BNO is a technique in which partial occluders are added to the spectacle lenses to suppress the abnormal peripheral visual motion information. This technique helps in reducing VMS symptoms (i.e., nausea, dizziness, balance difficulty, visual confusion). Case Report: A 44-year-old AA female presented for a routine eye exam with a history of mTBI approximately 33 years ago. She was suffering from severe dizziness for the last two years that was adversely impacting her ADLs. The dizziness occurred in all body positions and all environments throughout the day. She was diagnosed with vestibular hypofunction and had undergone vestibular therapy but reported little improvement. Neurological exam revealed dizziness with both OKN drum and hand movement, especially in the left visual field. BNO technique resulted in immediate relief of her dizziness symptoms. Conclusion: To our knowledge, this is the first case that illustrates how the BNO technique in isolation can be beneficial for patients with mTBI and vestibular hypofunction. It demonstrates the success that BNO has in filtering abnormal peripheral visual motion in these patients.

scholarly journals Importation of Entamoeba histolytica and predominance of Klebsiella pneumoniae in liver abscesses: a 7-year retrospective cohort study from the United Arab Emirates

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hussam Mousa ◽  
Ghada Salameh Mohammed Al-Bluwi ◽  
Zainab Fathi Mohammed Al Drini ◽  
Huda Imam Gasmelseed ◽  
Jamal Aldeen Alkoteesh ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
United Arab Emirates ◽  
Liver Abscess ◽  
Hospital Admissions ◽  
Indian Subcontinent ◽  
Pyogenic Liver Abscess ◽  
Primary Diagnosis ◽  
Incidence Rates ◽  
Liver Abscesses ◽  
Potential Risk Factors

Abstract Background There is a dearth of information on liver abscesses in the United Arab Emirates. Herein, we describe the clinical features of liver abscesses and determine their incidence rates and clinical outcomes. Methods We retrospectively reviewed the clinical charts of adult patients with a primary diagnosis of liver abscess at a major hospital over a 7-year period. Results Amongst 45 patients, 82.2% (37/45) had a pyogenic liver abscess (PLA) and 17.8% (8/45) had amoebic liver abscesses (ALA). Overall, patients were young (median age 42 years, IQR 35–52), mostly males (77.8%, 35/45) from the Indian subcontinent (55.6%, 25/45), presented with fever (88.9%, 40/45) and abdominal pain (88.9%, 40/45), and had a solitary abscess on imaging (71.1% (32/45). Crude annual incidence rates were 35.9/100,000 hospital admissions (95% CI 26.2–48.0) and 5.9/100,000 inhabitants (95% CI 4.3–7.9). All ALA patients were from the Indian subcontinent (100%, 8/8). Klebsiella pneumoniae was the most frequent pathogen in PLA (43.2% [16/37], 95% CI 27.1–60.5%). The hospital stay was shorter in ALA (7.5 days, IQR 7–8.5) than in PLA (14 days, IQR 9–17). No deaths were recorded within 30 days of hospitalisation. Conclusions ALA was exclusively seen in migrants from the Indian subcontinent, suggesting importation. Further research to characterise K. pneumoniae isolates and assess potential risk factors is needed.

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