IDDF2021-ABS-0094 Virulence factors and resistance genes carried differences of klebsiella pneumoniae isolated from patients with pneumonia and pyogenic liver abscess

Abstract Background: To date, little is known about virulence characteristics of pyogenic liver abscess (PLA) causing multidrug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae). It may be that these strains are rare. The aim of this study was to analyze the virulence characteristics and molecular epidemiology of 12 MDR strains from 163 PLA cases in a tertiary teaching hospital from the perspective of clinical characteristics, virulence phenotypes and genotypes.Results: The virulence phenotypes of the 12 PLA-causing MDR K. pneumoniae were similar or even more obvious than those of typical hypervirulent Klebsiella pneumoniae control strains according to the results of growth curves, string test, capsular quantification, serum killing test, biofilm formation assay, and infection model. These MDR strains were mainly non-K1/K2 serotypes and carried multiple virulence genes. Multilocus sequence typing (MLST) illustrated that the MDR strains were categorized into nine sequence types.Conclusions: This study is the first analysis of the virulence factors in PLA-causing MDR strains. Our data exhibited the coexistence of hypervirulence and multidrug resistance in PLA-causing MDR K. pneumoniae strains, and the clones of those PLA-causing MDR strains were diverse and scattered. The study was firstly found one ST11 carbapenem-resistant hypervirulent strain in PLA.

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First Case of Liver Abscess in Scandinavia Due to the International Hypervirulent Klebsiella Pneumoniae Clone ST23

The Open Microbiology Journal ◽

10.2174/1874285801408010022 ◽

2014 ◽

Vol 8 (1) ◽

pp. 22-24 ◽

Cited By ~ 11

Author(s):

Svend Gundestrup ◽

Carsten Struve ◽

Steen G. Stahlhut ◽

Dennis SchrØder Hansen

Keyword(s):

Case Report ◽

Klebsiella Pneumoniae ◽

Liver Abscess ◽

Virulence Factors ◽

Pyogenic Liver Abscess ◽

Predisposing Factors ◽

Foreign Travel ◽

First Case ◽

History Of

This is the first case report from Scandinavia of a pyogenic liver abscess caused by a Klebsiella pneumoniae isolate belonging to the international hyper virulent clone ST23. The patient, an 85-year old Caucasian, had no history of foreign travel or any classical predisposing factors for infection. The isolate was hypermucoviscous of capsular serotype K1 and carried the virulence factors aerobactin, allS, kfu and rmpA.

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Virulence Factors and Molecular Epidemiology of Pyogenic Liver Abscess Causing Multidrug Resistant Klebsiella pneumoniae in Wenzhou, China

10.21203/rs.3.rs-42660/v1 ◽

2020 ◽

Author(s):

Zhongyong Wang ◽

Siqin Zhang ◽

Na Huang ◽

Shixing Liu ◽

Ye Xu ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Molecular Epidemiology ◽

Liver Abscess ◽

Virulence Factors ◽

Virulence Genes ◽

Pyogenic Liver Abscess ◽

Multidrug Resistant ◽

Carbapenem Resistant ◽

Tertiary Teaching ◽

Tertiary Teaching Hospital

Abstract Background: To date, little is known about virulence characteristics of pyogenic liver abscess (PLA) causing multidrug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae). It may be these strains are rare. The aim of this study was to analyze the virulence and molecular epidemiology of 12 MDR strains from 163 PLA cases in a tertiary teaching hospital from the perspective of clinical characteristics, virulence phenotypes and genotypes.Results: The virulence phenotypes of the twelve PLA-causing MDR K. pneumoniae were similar or even more obvious than those of sensitive hypervirulent Klebsiella pneumoniae control strains. These MDR strains were mainly non-K1/K2 serotypes and carried multiple virulence genes. Multilocus sequence typing (MLST) revealed the PLA-causing MDR strains had low clone correlation.Conclusions: This study was the first analysis on virulence factors of PLA-causing MDR strains. The virulent factors exhibited the coexistence of hypervirulence and multidrug resistance in PLA-causing MDR K. pneumoniae strains, and these MDR strains were mainly polyclonal spread and there was firstly found one ST11 carbapenem-resistant hypervirulent strain in PLA.

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Klebsiella pneumoniae induced pyogenic liver abscess in critically ill patients: a retrospective study from a Chinese medical center, 1994-2015

10.26226/morressier.57c5383dd462b80296c9bad1 ◽

2016 ◽

Author(s):

Yun Qian

Keyword(s):

Retrospective Study ◽

Klebsiella Pneumoniae ◽

Critically Ill ◽

Liver Abscess ◽

Critically Ill Patients ◽

Medical Center ◽

Pyogenic Liver Abscess

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Importation of Entamoeba histolytica and predominance of Klebsiella pneumoniae in liver abscesses: a 7-year retrospective cohort study from the United Arab Emirates

Tropical Diseases Travel Medicine and Vaccines ◽

10.1186/s40794-021-00140-8 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Hussam Mousa ◽

Ghada Salameh Mohammed Al-Bluwi ◽

Zainab Fathi Mohammed Al Drini ◽

Huda Imam Gasmelseed ◽

Jamal Aldeen Alkoteesh ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

United Arab Emirates ◽

Liver Abscess ◽

Hospital Admissions ◽

Indian Subcontinent ◽

Pyogenic Liver Abscess ◽

Primary Diagnosis ◽

Incidence Rates ◽

Liver Abscesses ◽

Potential Risk Factors

Abstract Background There is a dearth of information on liver abscesses in the United Arab Emirates. Herein, we describe the clinical features of liver abscesses and determine their incidence rates and clinical outcomes. Methods We retrospectively reviewed the clinical charts of adult patients with a primary diagnosis of liver abscess at a major hospital over a 7-year period. Results Amongst 45 patients, 82.2% (37/45) had a pyogenic liver abscess (PLA) and 17.8% (8/45) had amoebic liver abscesses (ALA). Overall, patients were young (median age 42 years, IQR 35–52), mostly males (77.8%, 35/45) from the Indian subcontinent (55.6%, 25/45), presented with fever (88.9%, 40/45) and abdominal pain (88.9%, 40/45), and had a solitary abscess on imaging (71.1% (32/45). Crude annual incidence rates were 35.9/100,000 hospital admissions (95% CI 26.2–48.0) and 5.9/100,000 inhabitants (95% CI 4.3–7.9). All ALA patients were from the Indian subcontinent (100%, 8/8). Klebsiella pneumoniae was the most frequent pathogen in PLA (43.2% [16/37], 95% CI 27.1–60.5%). The hospital stay was shorter in ALA (7.5 days, IQR 7–8.5) than in PLA (14 days, IQR 9–17). No deaths were recorded within 30 days of hospitalisation. Conclusions ALA was exclusively seen in migrants from the Indian subcontinent, suggesting importation. Further research to characterise K. pneumoniae isolates and assess potential risk factors is needed.

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Prognostic Factors and Visual Outcomes of Pyogenic Liver Abscess-Related Endogenous Klebsiella pneumoniae Endophthalmitis: A 20-year retrospective review

Scientific Reports ◽

10.1038/s41598-018-37643-y ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 10

Author(s):

Yi-Hua Chen ◽

Ya-Han Li ◽

Yu-Jr Lin ◽

Yen-Po Chen ◽

Nan-Kai Wang ◽

...

Keyword(s):

Prognostic Factors ◽

Klebsiella Pneumoniae ◽

Liver Abscess ◽

Retrospective Review ◽

Pyogenic Liver Abscess ◽

Visual Outcomes

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Novel complication of an emerging disease: Invasive Klebsiella pneumoniae liver abscess syndrome as a cause of acute respiratory distress syndrome

Clinics and Practice ◽

10.4081/cp.2018.1021 ◽

2018 ◽

Cited By ~ 2

Author(s):

Anupam Gupta ◽

Saad Bhatti ◽

Anatoly Leytin ◽

Oleg Epelbaum

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Klebsiella Pneumoniae ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Liver Abscess ◽

English Language ◽

Distress Syndrome ◽

Pyogenic Liver Abscess ◽

The Subject ◽

Language Literature

Klebsiella pneumoniae is an increasingly recognized cause of a unique invasive syndrome manifesting as pyogenic liver abscess and hematogenous extrahepatic dissemination to a variety of sites, including the lung. Originally described only in Asia, this entity has now been reported across continents and ethnicities. Intrathoracic complications of invasive Klebsiella pneumoniae liver abscess syndrome (IKPLAS) have been characterized sporadically but have not been the subject of an all-encompassing investigation. Review of the English-language literature yields no reports of the acute respiratory distress syndrome as a consequence of IKPLAS. Herein we report what, to our knowledge, is the first such description.

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