scholarly journals Inhibition of Human Telomerase Reverse Transcritpase (hTERT) and Telomerase Activity by Curcumin in Human Mammary Epithelial and Breast Carcinoma Cell Lines

2001 ◽  
Vol 1 ◽  
pp. 109-109
Author(s):  
Chappail Ramachandran ◽  
Hugo B. Fonseca ◽  
Perseus Jhabvala ◽  
Steven J. Melnick ◽  
Enrique Escalon
Keyword(s):  
Breast Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Telomerase Activity ◽  
Mammary Epithelial ◽  
Carcinoma Cell Lines ◽  
Human Mammary Epithelial ◽  
Breast Carcinoma Cell Lines ◽  
Human Telomerase

Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines

1998 ◽  
Vol 48 (3) ◽  
pp. 195-203 ◽  
Author(s):  
Edward Kyu-Ho Han ◽  
Nadir Arber ◽  
Hirofumi Yamamoto ◽  
Jin T.E. Lim ◽  
Tom Delohery ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Mammary Epithelial ◽  
Carcinoma Cell Lines ◽  
Human Mammary Epithelial ◽  
Breast Carcinoma Cell Lines

scholarly journals Effect of Invasion of Borrelia burgdorferi in Normal and Neoplastic Mammary Epithelial Cells

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1295
Author(s):  
Gauri Gaur ◽  
Janhavi Y. Sawant ◽  
Ankita S. Chavan ◽  
Vishwa A. Khatri ◽  
Yueh-Hsin Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Epithelial Cells ◽  
Borrelia Burgdorferi ◽  
Cell Lines ◽  
Mammary Epithelial Cells ◽  
Carcinoma Cell ◽  
Mammary Epithelial ◽  
Carcinoma Cell Lines ◽  
Breast Carcinoma Cell Lines

Borrelia burgdorferi, the causative agent of Lyme Disease, is known to be able to disseminate and colonize various organs and tissues of its hosts, which is very crucial for its pathogenicity and survival. Recent studies have shown the presence of B. burgdorferi DNA in various breast cancer tissues, in some with poor prognosis, which raises the question about whether B. burgdorferi can interact with mammary epithelial cells and could have any effect on their physiology, including tumorigenic processes. As the model in this study, we have used MCF 10A normal and MDA-MB-231 tumorigenic mammary epithelial cells and infected both cell lines with B. burgdorferi. Our immunofluorescence and confocal microscopy results showed that B. burgdorferi is capable of invading normal epithelial and breast carcinoma cell lines within 24 h; however, the infection rate for the breast carcinoma cell lines was significantly higher. While the infection of epithelial cells with B. burgdorferi did not cause any changes in cell proliferation rates, it showed a significant effect on the invasion and migratory capacity of the breast cancer cells, but not on the normal epithelial cells, as determined by Matrigel invasion and wound healing assays. We have also found that the levels of expression of several epithelial–mesenchymal transition (EMT) markers (fibronectin, vimentin, and Twist1/2) changed, with a significant increase in tissue remodeling marker (MMP-9) in MDA-MB-231 cells demonstrated by quantitative Western blot analyses. This observation further confirmed that B. burgdorferi infection can affect the in vitro migratory and invasive properties of MDA-MB-231 tumorigenic mammary epithelial cells. In summary, our results suggest that B. burgdorferi can invade breast cancer tumor cells and it can increase their tumorigenic phenotype, which urges the need for further studies on whether B. burgdorferi could have any role in breast cancer development.

scholarly journals Effects of tamoxifen on telomerase activity in breast carcinoma cell lines

Cancer ◽  
1999 ◽  
Vol 85 (7) ◽  
pp. 1523-1529 ◽  
Author(s):  
Wade K. Aldous ◽  
Amber J. Marean ◽  
Mary J. DeHart ◽  
Louis A. Matej ◽  
Katherine H. Moore
Keyword(s):  
Breast Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Telomerase Activity ◽  
Carcinoma Cell Lines ◽  
Breast Carcinoma Cell Lines

scholarly journals Overexpression of microRNA-24 increases the sensitivity to paclitaxel in drug-resistant breast carcinoma cell lines via targeting ABCB9

2016 ◽  
Vol 12 (5) ◽  
pp. 3905-3911 ◽  
Author(s):  
Jian-Ping Gong ◽  
Liu Yang ◽  
Jun-Wei Tang ◽  
Peng Sun ◽  
Qing Hu ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Drug Resistant ◽  
Carcinoma Cell Lines ◽  
Breast Carcinoma Cell Lines

Chemical composition, anti-angiogenic and cytotoxicity activities of the essential oils ofCymbopogan citratus(lemon grass) against colorectal and breast carcinoma cell lines

2012 ◽  
Vol 24 (5) ◽  
pp. 453-459 ◽  
Author(s):  
Suthagar Pillai Piaru ◽  
Shanmugapriya Perumal ◽  
Lee Wei Cai ◽  
Roziahanim Mahmud ◽  
Amin Malik Shah Abdul Majid ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Breast Carcinoma ◽  
Essential Oils ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Lemon Grass ◽  
Cytotoxicity Activities ◽  
Breast Carcinoma Cell Lines
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