scholarly journals Reduced Suprathreshold Auditory Nerve Responses are Associated with Thinner Temporal Cortex and Slower Processing Speed in Presbycusis

2020 ◽  
Author(s):  
Paul H. Delano ◽  
Chama Belkhiria ◽  
Rodrigo C. Vergara ◽  
Melissa Martínez ◽  
Alexis Leiva ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cognitive Decline ◽  
Processing Speed ◽  
Auditory Nerve ◽  
Structural Changes ◽  
Temporal Cortex ◽  
Auditory Brainstem ◽  
Inferior Temporal Cortex ◽  
Auditory Brainstem Responses ◽  
Trail Making

AbstractEpidemiological evidence shows an association between hearing loss and dementia in elderly people. However, the mechanisms that connect hearing impairments and cognitive decline are still unknown. Here we propose that a suprathreshold auditory-nerve impairment is associated with cognitive decline and brain atrophy. Methods: audiological, neuropsychological, and brain structural 3-Tesla MRI data were obtained from elders with different levels of hearing loss recruited in the ANDES cohort. The amplitude of waves I (auditory nerve) and V (midbrain) from auditory brainstem responses were measured at 80 dB nHL. We also calculated the ratio between wave V and I as a proxy of a suprathreshold brainstem function. Results: we included a total of 101 subjects (age: 73.5 ± 5.2 years (mean ± SD), mean education: 9.5 ± 4.2 years, and mean audiogram thresholds (0.5-4 kHz): 25.5 ± 12.0 dB HL). We obtained reliable suprathreshold waves V in all subjects (n=101), while replicable waves I were obtained in 92 subjects (91.1%). Partial Spearman correlations (corrected by age, gender, education and hearing thresholds) showed that reduced suprathreshold wave I responses were associated with thinner bilateral medial and inferior temporal cortex and, with slower processing speed as evidenced by the Trail-Making Test-A and digit symbol tests. Non-significant correlations were obtained between wave I amplitudes and other cognitive domains. Conclusions: These results evidence that reduced suprathreshold auditory nerve responses in presbycusis are associated with slower processing speed and brain structural changes in the temporal cortex.

Hearing recovery from deafness caused by bromate intoxication

2018 ◽  
Vol 132 (11) ◽  
pp. 1039-1041 ◽  
Author(s):  
J Suzuki ◽  
Y Takanashi ◽  
A Koyama ◽  
Y Katori
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Brainstem ◽  
Sensorineural Hearing ◽  
Auditory Brainstem Responses ◽  
Common Symptom ◽  
Hearing Recovery ◽  
Continuous Haemodiafiltration

AbstractObjectivesSodium bromate is a strong oxidant, and bromate intoxication can cause irreversible severe-to-profound sensorineural hearing loss. This paper reports the first case in the English literature of bromate-induced hearing loss with hearing recovery measured by formal audiological assessment.Case reportA 72-year-old woman was admitted to hospital with complaints of profound hearing loss, nausea, diarrhoea and anuria after bromate ingestion in a suicide attempt. On admission, pure tone audiometry and auditory brainstem responses showed profound bilateral deafness. Under the diagnosis of bromate-induced acute renal failure and sensorineural hearing loss, continuous haemodiafiltration was performed. When dialysis was discontinued, pure tone audiometry and auditory brainstem responses showed partial threshold recovery from profound deafness.ConclusionSevere-to-profound sensorineural hearing loss is a common symptom of bromate intoxication. Bromate-induced hearing loss may be partially treated, and early application of continuous haemodiafiltration might be useful as a treatment for this intractable condition.

Auditory Brainstem Responses in a Case of High-Frequency Conductive Hearing Loss

1985 ◽  
Vol 50 (4) ◽  
pp. 346-350 ◽  
Author(s):  
Michael P. Gorga ◽  
Jan K. Reiland ◽  
Kathryn A. Beauchaine
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Conductive Hearing Loss ◽  
Auditory Brainstem ◽  
Intensity Function ◽  
Auditory Brainstem Responses ◽  
Normal Limits ◽  
Interpeak Latency ◽  
Lower Limits ◽  
Conductive Hearing

Click-evoked auditory brainstem responses were measured in a patient with high-frequency conductive hearing loss. As is typical in cases of conductive hearing loss, Wave I latency was prolonged beyond normal limits. Interpeak latency differences were just below the lower limits of the normal range. The Wave V latency-intensity function, however was abnormally steep. This pattern is explained by the hypothesis that the slope of the latency-intensity function is determined principally by the configuration of the hearing loss. In cases of high-frequency hearing loss (regardless of the etiology), the response may be dominated by more apical regions of the cochlea at lower intensities and thus have a longer latency.

Auditory Brainstem Responses in Noise-Induced Permanent Hearing Loss

1988 ◽  
Vol 27 (1) ◽  
pp. 36-41 ◽  
Author(s):  
G. Almadori ◽  
F. Ottaviani ◽  
G. Paludetti ◽  
M. Rosignoli ◽  
L. Gallucci ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses

Auditory Brainstem Responses in Ears with Hearing Loss: Case Studies

1981 ◽  
Vol 10 (4) ◽  
pp. 247-254 ◽  
Author(s):  
C. D. Bauch ◽  
D. E. Rose ◽  
S. G. Harner
Keyword(s):  
Hearing Loss ◽  
Case Studies ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses

Accuracy of Synchrony Judgment and its Relation to the Auditory Brainstem Response: the Difference Between Pianists and Non-Pianists

2011 ◽  
Vol 15 (8) ◽  
pp. 962-971
Author(s):  
Eriko Aiba ◽  
◽  
Koji Kazai ◽  
Takayuki Shimotomai ◽  
Toshie Matsui ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Physiological Responses ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Judgment Accuracy ◽  
Synchrony Judgment ◽  
Significant Difference ◽  
Brainstem Response ◽  
The Difference ◽  
Onset Asynchrony

Synchrony judgment is one of the most important abilities for musicians. Only a few milliseconds of onset asynchrony result in a significant difference in musical expression. Using behavioural responses and Auditory Brainstem Responses (ABR), this study investigates whether synchrony judgment accuracy improves with training and, if so, whether physiological responses are also changed through training. Psychoacoustic experiments showed that accuracy of synchrony judgment of pianists was higher than that of non-pianists, implying that pianists’ ability to perceive tones increased through training. ABRmeasurements also showed differences between pianists and non-pianists. However, cochlear delay, an asymmetric aspect of temporal processing in the human auditory system, did not change with training. It is possible that training improved ability related to temporal tone perception and that training may increase synchrony in auditory nerve firing.

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