Reliable identification of protein-protein interactions by crosslinking mass spectrometry
Keyword(s):
Crosslinking mass spectrometry is widening its scope from structural analyzes of purified multi-protein complexes towards systems-wide analyzes of protein-protein interactions. Assessing the error in these large datasets is currently a challenge. Using a controlled large-scale analysis of Escherichia coli cell lysate, we demonstrate a reliable false-discovery rate estimation procedure for protein-protein interactions identified by crosslinking mass spectrometry.
Keyword(s):
2011 ◽
pp. 395-425
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2016 ◽
Vol 2016
(11)
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pp. pdb.top083543
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2016 ◽
Vol 2016
(11)
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pp. pdb.prot090027
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2017 ◽
Vol 114
(9)
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pp. 2224-2229
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