scholarly journals Human Prostate Cancer-Associated Macrophage Subtypes with Prognostic Potential Revealed by Single-cell Transcriptomics

Author(s):  
Joseph C Siefert ◽  
Bianca Cioni ◽  
Mauro J Muraro ◽  
Mohammed Alshalalfa ◽  
Judith Vivié ◽  
...  

ABSTRACTMacrophages in the tumor microenvironment are causally linked with prostate cancer development and progression, yet little is known about their composition in neoplastic human tissue. By performing single cell transcriptomic analysis of human prostate cancer resident macrophages, three distinct populations were identified in the diseased prostate. Unexpectedly, macrophages isolated from the tumor-adjacent site of the prostatectomy specimen were identical to those from the tumorous site. Markers associated with canonical M1 and M2 macrophage phenotypes were identifiable, however these were not the main factors defining unique subtypes. The genes selectively associated with each macrophage cluster were used to develop a gene signature which was highly associated with both recurrence-free and metastasis-free survival. These results highlight the relevance of tissue-specific macrophage subtypes in the tumour microenvironment for prostate cancer progression and demonstrates the utility of profiling single-cell transcriptomics in human tumor samples as a strategy to design gene classifiers for patient prognostication.

2021 ◽  
pp. molcanres.0740.2020
Author(s):  
Joseph C Siefert ◽  
Bianca Cioni ◽  
Mauro J Muraro ◽  
Mohammed Alshalalfa ◽  
Judith Vivie ◽  
...  

2006 ◽  
Vol 118 (9) ◽  
pp. 2123-2131 ◽  
Author(s):  
William A. Ricke ◽  
Kenichiro Ishii ◽  
Emily A. Ricke ◽  
Jeff Simko ◽  
Yuzhuo Wang ◽  
...  

2007 ◽  
Vol 13 (20) ◽  
pp. 6040-6048 ◽  
Author(s):  
Ruoxiang Wang ◽  
Jianchun Xu ◽  
Nicola Mabjeesh ◽  
Guodong Zhu ◽  
Jianguang Zhou ◽  
...  

2017 ◽  
Vol 5 (2) ◽  
pp. 75-83 ◽  
Author(s):  
Anand Setty Balakrishnan ◽  
Abel Arul Nathan ◽  
Mukesh Kumar ◽  
Sudhakar Ramamoorthy ◽  
Sathish Kumar Ramia Mothilal

2015 ◽  
Vol 35 (6) ◽  
Author(s):  
Haifeng Wang ◽  
Xu Gao ◽  
Xin Lu ◽  
Yan Wang ◽  
Chunfei Ma ◽  
...  

The mitotic regulator Hec1 (highly expressed in cancer), is a member of a conserved Ndc80 (nuclear division cycle 80) complex that regulates mitotic processes. We find that Hec1 is consistently overexpressed in human prostate cancer and Hec1 is closely linked with human prostate cancer progression through the meditator LncRNA BX647187. Our studies may contribute to understand the molecular mechanism of PCa pathogenesis and clinical therapy.


1994 ◽  
Vol 9 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Mark G. Bandyk ◽  
Louis L. Pisters ◽  
Andrew C. Von Eshenbach ◽  
Leland W. K. Chung ◽  
Lian Zhao ◽  
...  

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