scholarly journals Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations

2020 ◽  
Author(s):  
Fabien Naneix ◽  
Ioannis Bakoyiannis ◽  
Marianela Santoyo-Zedillo ◽  
Clémentine Bosch-Bouju ◽  
Gustavo Pacheco-Lopez ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Basolateral Amygdala ◽  
Memory Deficits ◽  
Ventral Hippocampus ◽  
Brain Regions ◽  
Obesity Prevalence ◽  
Odor Aversion ◽  
Object Recognition Memory

1ABSTRACTIn addition to numerous metabolic comorbidities, obesity is associated with several adverse neurobiological outcomes, especially learning and memory alterations. Obesity prevalence is rising dramatically in youth and is persisting in adulthood. This is especially worrying since adolescence is a crucial period for the maturation of certain brain regions playing a central role in memory processes such as the hippocampus and the amygdala. We previously showed that periadolescent exposure to obesogenic high-fat diet (HFD) had opposite effects on hippocampus- and amygdala-dependent memory, impairing the former and enhancing the latter. However, the causal role of these two brain regions in periadolescent HFD-induced memory alterations remains unclear. Here, we first showed that periadolescent HFD induced long-term, but not short-term, object recognition memory deficits, specifically when rats were exposed to a novel context. Using chemogenetic approaches to inhibit targeted brain regions, we then demonstrated that recognition memory deficits are dependent on the activity of the ventral hippocampus, but not the basolateral amygdala. On the contrary, the HFD-induced enhancement of conditioned odor aversion requires specifically amygdala activity. Taken together, these findings suggest that HFD consumption throughout adolescence impairs long-term object recognition memory through the overactivation of the ventral hippocampus during memory acquisition. Moreover, these results further highlight the bidirectional effects of adolescent HFD on hippocampal and amygdala functions.

Long-Term Visual Object Recognition Memory in Aged Rats

2008 ◽  
Vol 11 (2) ◽  
pp. 333-339 ◽  
Author(s):  
Daniela Platano ◽  
Patrizia Fattoretti ◽  
Marta Balietti ◽  
Carlo Bertoni-Freddari ◽  
Giorgio Aicardi
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Visual Object ◽  
Visual Object Recognition ◽  
Aged Rats ◽  
Object Recognition Memory

scholarly journals Synaptic biomarker reduction and impaired cognition in the sub-chronic PCP mouse model for schizophrenia

2019 ◽  
Vol 34 (1) ◽  
pp. 115-124 ◽  
Author(s):  
John Gigg ◽  
Francesca McEwan ◽  
Rebecca Smausz ◽  
Joanna Neill ◽  
Michael K Harte
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Frontal Cortex ◽  
Ventral Hippocampus ◽  
Acid Decarboxylase ◽  
Object Recognition Memory ◽  
Synaptic Markers ◽  
Inter Trial Interval ◽  
First Time ◽  
Interval Expression

Background: Sub-chronic phencyclidine treatment (scPCP) provides a translational rat model for cognitive impairments associated with schizophrenia (CIAS). CIAS genetic risk factors may be more easily studied in mice; however, CIAS associated biomarker changes are relatively unstudied in the scPCP mouse. Aim: To characterize deficits in object recognition memory and synaptic markers in frontal cortex and hippocampus of the scPCP mouse. Methods: Female c57/bl6 mice received 10 daily injections of PCP (scPCP; 10 mg/kg, s.c.) or vehicle ( n = 8/group). Mice were tested for novel object recognition memory after either remaining in the arena (‘no distraction’) or being removed to a holding cage (‘distraction’) during the inter-trial interval. Expression changes for parvalbumin (PV), glutamic acid decarboxylase (GAD67), synaptosomal-associated protein 25 (SNAP-25) and postsynaptic density 95 (PDS95) were measured in frontal cortex, dorsal and ventral hippocampus. Results: scPCP mice showed object memory deficits when distracted by removal from the arena, where they treated previously experienced objects as novel at test. scPCP significantly reduced PV expression in all regions and lower PSD95 levels in frontal cortex and ventral hippocampus. Levels of GAD67 and SNAP-25 were unchanged. Conclusions: We show for the first time that scPCP mice: (a) can encode and retain object information, but that this memory is susceptible to distraction; (b) display amnesia after distraction; and (c) express reduced PV and PSD95 in frontal cortex and hippocampus. These data further support reductions in PV-dependent synaptic inhibition and NMDAR-dependent glutamatergic plasticity in CIAS and highlight the translational significance of the scPCP mouse.

Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats

2010 ◽  
Vol 635 (1-3) ◽  
pp. 124-128 ◽  
Author(s):  
Gilberto L. Pardo Andreu ◽  
Natasha Maurmann ◽  
Gustavo Kellermann Reolon ◽  
Caroline B. de Farias ◽  
Gilberto Schwartsmann ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Naturally Occurring ◽  
Object Recognition Memory

scholarly journals Glucocorticoid enhancement of recognition memory via basolateral amygdala-driven facilitation of prelimbic cortex interactions

2019 ◽  
Vol 116 (14) ◽  
pp. 7077-7082 ◽  
Author(s):  
Areg Barsegyan ◽  
Gabriele Mirone ◽  
Giacomo Ronzoni ◽  
Chunan Guo ◽  
Qi Song ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Memory Consolidation ◽  
Basolateral Amygdala ◽  
Emotional Arousal ◽  
Brain Regions ◽  
Prelimbic Cortex ◽  
Stress Hormone ◽  
Functional Connections ◽  
Functional Interactions

Extensive evidence indicates that the basolateral amygdala (BLA) interacts with other brain regions in mediating stress hormone and emotional arousal effects on memory consolidation. Brain activation studies have shown that arousing conditions lead to the activation of large-scale neural networks and several functional connections between brain regions beyond the BLA. Whether such distal interactions on memory consolidation also depend on BLA activity is not as yet known. We investigated, in male Sprague–Dawley rats, whether BLA activity enables prelimbic cortex (PrL) interactions with the anterior insular cortex (aIC) and dorsal hippocampus (dHPC) in regulating glucocorticoid effects on different components of object recognition memory. The glucocorticoid receptor (GR) agonist RU 28362 administered into the PrL, but not infralimbic cortex, immediately after object recognition training enhanced 24-hour memory of both the identity and location of the object via functional interactions with the aIC and dHPC, respectively. Importantly, posttraining inactivation of the BLA by the noradrenergic antagonist propranolol abolished the effect of GR agonist administration into the PrL on memory enhancement of both the identity and location of the object. BLA inactivation by propranolol also blocked the effect of GR agonist administration into the PrL on inducing changes in neuronal activity within the aIC and dHPC during the postlearning consolidation period as well as on structural changes in spine morphology assessed 24 hours later. These findings provide evidence that BLA noradrenergic activity enables functional interactions between the PrL and the aIC and dHPC in regulating stress hormone and emotional arousal effects on memory.

Facilitation of long-term object recognition memory by pretraining administration of diphenyl diselenide in mice

2003 ◽  
Vol 341 (3) ◽  
pp. 217-220 ◽  
Author(s):  
Renato M. Rosa ◽  
Debora G. Flores ◽  
Helmoz R. Appelt ◽  
Antônio Luiz Braga ◽  
João Antônio Pêgas Henriques ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Diphenyl Diselenide ◽  
Object Recognition Memory

scholarly journals BDNF as a Putative Target for Standardized Extract of Ginkgo biloba-Induced Persistence of Object Recognition Memory

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3326
Author(s):  
Beatriz G. Muratori ◽  
Cláudia R. Zamberlam ◽  
Thaís B. Mendes ◽  
Bruno H. N. Nozima ◽  
Janete M. Cerutti ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Differential Expression ◽  
Hippocampal Formation ◽  
Training Session ◽  
Long Term Memory ◽  
Dependent Manner ◽  
Bdnf Expression ◽  
Object Recognition Memory

Despite considerable progress on the study of the effect of standardized extract of Gingko biloba (EGb) on memory processes, our understanding of its role in the persistence of long-term memory (LTM) and the molecular mechanism underlying its effect, particularly episodic-like memory, is limited. We here investigated the effects of EGb on the long-term retention of recognition memory and its persistence and BDNF expression levels in the dorsal hippocampal formation (DHF). Adult male Wistar rats (n = 10/group) were handled for 10 min/5 day. On day 6, the animals were treated with vehicle or 0.4 mg/kg diazepam (control groups) or with EGb (250, 500 or 100 mg/kg) 30 min before the training session (TR1), in which the animals were exposed to two sample objects. On day 7, all rats underwent a second training session (TR2) as described in the TR1 but without drug treatment. Object recognition memory (ORM) was evaluated on day 8 (retention test, T1) and day 9 (persistence test, T2). At the end of T1or T2, animals were decapitated, and DHF samples were frozen at −80 °C for analyses of the differential expression of BDNF by Western blotting. EGb-treated groups spent more time exploring the novel object in T2 and showed the highest recognition index (RI) values during the T1 and T2, which was associated with upregulation of BDNF expression in the DHF in a dose-and session-dependent manner. Our data reveal, for the first time, that EGb treatment before acquisition of ORM promotes persistence of LTM by BDNF differential expression.

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