scholarly journals Ultrafast contour imaging for time-domain diffuse optical tomography

2020 ◽  
Author(s):  
Xiaohua Feng ◽  
Liang Gao

Diffuse optical tomography (DOT) is well known to be ill-posed and suffers from a poor resolution. While time domain DOT can bolster the resolution by time-gating to extract weakly scattering photons, it is often confronted by an inferior signal to noise ratio and a low measurement density. This is particularly problematic for non-contact DOT imaging of non-planar objects, which faces an inherent tradeoff between the light collection efficiency and depth of field. We present here ultrafast contour imaging, a method that enables efficient light collection over curved surfaces with a dense spatiotemporal sampling of diffused light, allowing DOT imaging in the object’s native geometry with an improved resolution. We demonstrated our approach with both phantom and small animal imaging results. ©2020 Optical Society of America

2008 ◽  
Vol 13 (6) ◽  
pp. 060501 ◽  
Author(s):  
Mehmet Burcin Unlu ◽  
Yuting Lin ◽  
Ozlem Birgul ◽  
Orhan Nalcioglu ◽  
Gultekin Gulsen

2016 ◽  
Vol 2016 ◽  
pp. 1-23 ◽  
Author(s):  
Yves Bérubé-Lauzière ◽  
Matteo Crotti ◽  
Simon Boucher ◽  
Seyedrohollah Ettehadi ◽  
Julien Pichette ◽  
...  

This paper discusses instrumentation based on multiview parallel high temporal resolution (<50 ps) time-domain (TD) measurements for diffuse optical tomography (DOT) and a prospective view on the steps to undertake as regards such instrumentation to make TD-DOT a viable technology for small animal molecular imaging. TD measurements provide information-richest data, and we briefly review the interaction of light with biological tissues to provide an understanding of this. This data richness is yet to be exploited to its full potential to increase the spatial resolution of DOT imaging and to allow probing, via the fluorescence lifetime, tissue biochemical parameters, and processes that are otherwise not accessible in fluorescence DOT. TD data acquisition time is, however, the main factor that currently compromises the viability of TD-DOT. Current high temporal resolution TD-DOT scanners simply do not integrate sufficient detection channels. Based on our past experience in developing TD-DOT instrumentation, we review and discuss promising technologies to overcome this difficulty. These are single photon avalanche diode (SPAD) detectors and fully parallel highly integrated electronics for time-correlated single photon counting (TCSPC). We present experimental results obtained with such technologies demonstrating the feasibility of next-generation multiview TD-DOT therewith.


2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Zi-Jing Lin ◽  
Haijing Niu ◽  
Lin Li ◽  
Hanli Liu

We report the feasibility of three-dimensional (3D) volumetric diffuse optical tomography for small animal imaging by using a CCD-camera-based imaging system with a newly developed depth compensation algorithm (DCA). Our computer simulations and laboratory phantom studies have demonstrated that the combination of a CCD camera and DCA can significantly improve the accuracy in depth localization and lead to reconstruction of 3D volumetric images. This approach may present great interests for noninvasive 3D localization of an anomaly hidden in tissue, such as a tumor or a stroke lesion, for preclinical small animal models.


2013 ◽  
Vol 24 (10) ◽  
pp. 105405 ◽  
Author(s):  
James A Guggenheim ◽  
Hector R A Basevi ◽  
Jon Frampton ◽  
Iain B Styles ◽  
Hamid Dehghani

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