scholarly journals Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human

2021 ◽  
Author(s):  
David Escobar Sanabria ◽  
Joshua E Aman ◽  
Valentina Zapata Amaya ◽  
Luke A Johnson ◽  
Hafsa Farooqi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Real Time ◽  
Brain Stimulation ◽  
Neural Activity ◽  
Beta Band ◽  
Beta Oscillations ◽  
Oscillatory Dynamics ◽  
Deep Brain

Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 8-35 Hz ("beta band") oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical stimulation with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16-22 Hz) neural activity in a PD patient. Amplification of targeted oscillations led to an increase in the variance of motor tracking delays, supporting the hypothesis that pallidal beta oscillations are linked to motor performance. Our results highlight the utility of eiDBS to characterize the pathophysiology of PD and other brain conditions in the human and develop personalized neuromodulation therapies.

The effects of levodopa and ongoing deep brain stimulation on subthalamic beta oscillations in Parkinson's disease

2010 ◽  
Vol 226 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Gaia Giannicola ◽  
Sara Marceglia ◽  
Lorenzo Rossi ◽  
Simona Mrakic-Sposta ◽  
Paolo Rampini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Beta Oscillations ◽  
Deep Brain

scholarly journals Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease

2018 ◽  
Vol 38 (19) ◽  
pp. 4556-4568 ◽  
Author(s):  
Doris D. Wang ◽  
Coralie de Hemptinne ◽  
Svjetlana Miocinovic ◽  
Jill L. Ostrem ◽  
Nicholas B. Galifianakis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Motor Cortex ◽  
Brain Stimulation ◽  
Primary Motor Cortex ◽  
Beta Oscillations ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

scholarly journals Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks

2021 ◽  
Author(s):  
Elie M Adam ◽  
Emery N. Brown ◽  
Nancy Kopell ◽  
Michelle M McCarthy
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Gamma Oscillations ◽  
Medium Spiny Neuron ◽  
Beta Oscillations ◽  
Movement Disability ◽  
Deep Brain

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is highly effective in alleviating movement disability in patients with Parkinson's disease (PD). However, its therapeutic mechanism of action is unknown. The healthy striatum exhibits rich dynamics resulting from an interaction of beta, gamma and theta oscillations. These rhythms are at the heart of selection, initiation and execution of motor programs, and their loss or exaggeration due to dopamine (DA) depletion in PD is a major source of the behavioral deficits observed in PD patients. Interrupting abnormal rhythms and restoring the interaction of rhythms as observed in the healthy striatum may then be instrumental in the therapeutic action of DBS. We develop a biophysical networked model of a BG pathway to study how abnormal beta oscillations can emerge throughout the BG in PD, and how DBS can restore normal beta, gamma and theta striatal rhythms. Our model incorporates STN projections to the striatum, long known but understudied, that were recently shown to preferentially target fast spiking interneurons (FSI) in the striatum. We find that DBS in STN is able to normalize striatal medium spiny neuron (MSN) activity by recruiting FSI dynamics, and restoring the inhibitory potency of FSIs observed in normal condition. We also find that DBS allows the re-expression of gamma and theta rhythms, thought to be dependent on high DA levels and thus lost in PD, through cortical noise control. Our study shows how BG connectivity can amplify beta oscillations, and delineates the role of DBS in disrupting beta oscillations and providing corrective input to STN efferents to restore healthy striatal dynamics. It also suggests how gamma oscillations can be leveraged to enhance or supplement DBS treatment and improve its effectiveness.

scholarly journals Pathological Beta Burst Dynamics are Conserved Across Different Movements in Parkinson’s Disease

2020 ◽  
Author(s):  
Raumin S. Neuville ◽  
Ross. W. Anderson ◽  
Matthew N. Petrucci ◽  
Jordan E. Parker ◽  
Kevin B. Wilkins ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Neural Activity ◽  
Resting State ◽  
Closed Loop ◽  
Peak Frequency ◽  
Beta Band ◽  
Beta Power ◽  
Deep Brain

AbstractBackgroundResting state beta band (13 – 30 Hz) oscillations represent pathological neural activity in Parkinson’s disease (PD). It is unknown whether the peak frequency or dynamics of beta oscillations change among rest, fine, limb and axial movements. This will be critical for the development and feasibility of closed loop deep brain stimulation (DBS) algorithms during resting and movement states.MethodsSubthalamic (STN) local field potentials (LFPs) were recorded from a sensing neurostimulator (Activa® PC+S, Medtronic Inc.,) and synchronized to kinematic recordings in twelve PD participants off medication/off STN DBS during thirty seconds of repetitive alternating finger tapping, wrist-flexion extension, stepping in place, and free walking. Beta power peaks and beta burst dynamics were identified by custom algorithms; beta burst dynamics were compared among rest and movement tasks.ResultsResting state burst durations were longer in a PD beta band, which was elevated above the 1/f physiological spectrum compared to an overlapping band (p < 0.001). Beta power peaks were evident during fine, limb, and axial movements in 98% of movement trials; the peak frequencies were similar during movements and at rest. Burst duration, average and peak power were also similar among the four movement tasks across the group but varied within individuals.ConclusionsProlonged burst durations were a feature of PD bands elevated above and not of PD bands overlapping the 1/f spectrum. The conservation of rest/movement band peak frequency and burst dynamics during different activity states supports the feasibility of successful closed loop DBS algorithms driven by beta burst dynamics during different activities and at rest.HighlightsProlonged beta burst durations represent pathological neural activity in Parkinson’s diseaseBeta band peak frequencies are similar across rest, fine, limb and axial movementsBeta burst dynamics are similar among rest and different movement statesConservation of Parkinsonian neural characteristics across different activity states supports the feasibility of closed loop deep brain stimulation systems in daily life

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