Oligodendrocyte precursor cells guide the migration of cortical interneurons by unidirectional contact repulsion

The cerebral cortex is built by neural cells that migrate away from their birthplace. In the forebrain, ventrally-derived oligodendrocyte precursor cells (vOPCs) travel tangentially together with cortical interneurons (cINs) to reach the cortex. After birth, vOPCs form transient synapses with cINs before engaging later into myelination. Here we tested whether these populations interact during embryogenesis while migrating. By coupling histological analysis of mouse genetic models with live imaging, we showed that, while responding to the chemokine Cxcl12, vOPCs and cINs occupy mutually-exclusive forebrain territories. Moreover, vOPCs depletion selectively disrupts the migration and distribution of cINs. At the cellular level, we found that by promoting unidirectional contact-repulsion (UCoRe) of cINs, vOPCs steer their migration away from blood vessels and contribute to their allocation to proper migratory streams. UCoRe is thus an efficient strategy to spatially control the competition for a shared chemoattractant, thereby allowing cINs to reach proper cortical territories.

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Possible roles of Plexin-A4 in positioning of oligodendrocyte precursor cells in developing cerebral cortex

Neuroscience Letters ◽

10.1016/j.neulet.2012.04.005 ◽

2012 ◽

Vol 516 (2) ◽

pp. 259-264 ◽

Cited By ~ 6

Author(s):

Atsumasa Okada ◽

Yasuhiro Tomooka

Keyword(s):

Cerebral Cortex ◽

Precursor Cells ◽

Oligodendrocyte Precursor Cells ◽

Oligodendrocyte Precursor

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Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12

Neuroreport ◽

10.1097/01.wnr.0000227985.92551.9a ◽

2006 ◽

Vol 17 (11) ◽

pp. 1187-1190 ◽

Cited By ~ 43

Author(s):

Samaneh Maysami ◽

Dan Nguyen ◽

Franziska Zobel ◽

Caroline Pitz ◽

Sandra Heine ◽

...

Keyword(s):

Precursor Cells ◽

Oligodendrocyte Precursor Cells ◽

Chemokine Cxcl12 ◽

Oligodendrocyte Precursor

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Protocol to Isolate a Large Amount of Functional Oligodendrocyte Precursor Cells from the Cerebral Cortex of Adult Mice and Humans

PLoS ONE ◽

10.1371/journal.pone.0081620 ◽

2013 ◽

Vol 8 (11) ◽

pp. e81620 ◽

Cited By ~ 20

Author(s):

Eva María Medina-Rodríguez ◽

Francisco Javier Arenzana ◽

Ana Bribián ◽

Fernando de Castro

Keyword(s):

Cerebral Cortex ◽

Precursor Cells ◽

Oligodendrocyte Precursor Cells ◽

Adult Mice ◽

Oligodendrocyte Precursor

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Age-linked heterogeneity among oligodendrocyte precursor cells in the cerebral cortex of mice and human

10.1101/799544 ◽

2019 ◽

Author(s):

A Bribián ◽

EM Medina-Rodríguez ◽

F Josa-Prado ◽

I García-Álvarez ◽

I Machín-Díaz ◽

...

Keyword(s):

Cerebral Cortex ◽

Precursor Cells ◽

Oligodendrocyte Precursor Cells ◽

Cell Therapies ◽

Adult Human ◽

Adult Mice ◽

Proper Design ◽

Oligodendrocyte Precursor ◽

First Time ◽

Cerebral Cortex Tissue

ABSTRACTOligodendrocyte precursor cells (OPCs) are responsible for spontaneous remyelination after a demyelinating lesion. They are present in large parts of the mouse and human central nervous system, both during development and in adulthood, yet how their physiological behaviour is modified throughout life remains largely unknown. Moreover, the activity of adult human OPCs is still not fully understood. Significantly, most of the molecules involved in OPC-mediated remyelination are also involved in their development, a phenomenon that may be clinically relevant. In this article, we have systematically analyzed the intrinsic properties of OPCs isolated from the cerebral cortex of neonatal, postnatal and adult mice, as well as those recovered from neurosurgical adult human cerebral cortex tissue. We also analyze the response of these cells to two molecules that have known effects on OPC biology during development and that are overexpressed in individuals with Multiple Sclerosis (MS): FGF2 and anosmin-1. By analyzing intact OPCs for the first time with H-1 HR-MAS NMR spectroscopy, we show that these cells behave distinctly and that they have different metabolic patterns in function of their stage of maturity. Moreover, their response to FGF-2 and anosmin-1 differs in relation to their developmental stage and in function of the species. Our data reveal that the behaviour of adult human and mouse OPCs differs in a very dynamic way that should be considered when testing drugs and for the proper design of effective pharmacological and/or cell therapies for MS.

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