Approximation of the age distribution of cancer incidence using a mutational model

The approximation of the age distributions of cancer was carried out using a complex mutational model presented in our work [1]. Datasets from the American National Cancer Institute (SEER program) were used. We approximated the data of age distributions of lung, stomach, colon and breast cancer in women; cancer of the lung, stomach, colon and prostate in men. The average number of mutations (required for cancer formation) averaged over the four types of cancer is 5.25 mutations per cell in women and 5.5 mutations per cell in men. The average (over the four types of cancer) mutation rate is estimated as 0.0004 mutations per year per cell for women and 0.0008 mutations per year per cell for men. This article is a continuation of work [1].