scholarly journals Cognition-oriented treatments and physical exercise on cognitive function in Huntington's disease: Protocol for systematic review

2021 ◽  
Author(s):  
Katharine Huynh ◽  
Leila Nategh ◽  
Sharna Jamadar ◽  
Nellie Georgiou-Karistianis ◽  
Amit Lampit
Keyword(s):  
Systematic Review ◽  
Cognitive Function ◽  
Physical Exercise ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Primary Outcome ◽  
Eligibility Criteria ◽  
Cognitive Interventions ◽  
Meta Analyses

Introduction: Cognitive impairments are prevalent in Huntington's disease (HD), occurring many years prior to clinical diagnosis and are the most impactful on quality of life of patients. Cognitive interventions and exercise have been found to be efficacious in improving cognitive function in several clinical populations (e.g., older adults with mild cognitive impairment and dementia). However, the utility of cognitive interventions has not been systematically reviewed in HD. This systematic review aims to examine the efficacy of cognitive and physical interventions on cognitive function in HD. Methods: Electronic databases (MEDLINE, EMBASE, PsycINFO, CENTRAL) were searched through till 10 May 2021 for interventional studies investigating the effect of cognition-oriented treatments and physical exercise on cognitive function in individuals with HD, compared to any control or no control. The primary outcome is change on objective measures of cognition. Additional outcomes include change in psychosocial, functional and neuroimaging measures. Variations of effects based on population and study factors will be considered. Risk of bias will be assessed using the Cochrane RoB 2 tool and ROBINS-I tool. Where appropriate, outcomes will be pooled using random-effects meta-analyses, heterogeneity will be examined using tau2 and I2 statistics, and moderators will be examined using meta-regression models. Discussion: This review will systematically evaluate the efficacy of cognitive and physical interventions on improving cognitive function in HD. The eligibility criteria and planned analyses will allow for a comprehensive assessment of certainty in the evidence that will inform future trials and clinical practice. Registration: This protocol was registered on PROSPERO (CRD42021259152).

scholarly journals Evaluation of Preeclampsia Results after Use of Metformin in Gestation: Systematic Review and Meta-analysis

2018 ◽  
Vol 40 (11) ◽  
pp. 713-721 ◽  
Author(s):  
Iramar Nascimento ◽  
Guilherme Dienstmann ◽  
Matheus de Souza ◽  
Raquel Fleig ◽  
Carla Hoffmann ◽  
...  
Keyword(s):  
Systematic Review ◽  
Treatment Time ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Eligibility Criteria ◽  
Time Segment ◽  
Meta Analyses ◽  
The Cochrane Collaboration ◽  
Lower Correlation

Objective Does the use of metformin have an influence on the outcomes of preeclampsia (PE)? Sources of Data The descriptors pregnancy, metformin, treatment, and preeclampsia associated with the Boolean operators AND and OR were found in the MEDLINE, LILACS, Embase and Cochrane databases. A flowchart with exclusion criteria and inclusion strategy using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, and eligibility criteria was used. Data were extracted regarding the type of study, the applied dosage, treatment time, segment, bias risks, and the Patient, Intervention, Comparison and Outcome (PICO) strategy to identify the quality of the study. Selection of Studies Total number of journals in the initial search (n = 824); exclusions from repeated articles on different search engines (n = 253); exclusions after reading the titles, when the title had no correlations with the proposed theme (n = 164); exclusions due to incompatibility with the criteria established in the methodological analysis (n = 185), exclusion of articles with lower correlation with the objective of the present study (n = 187); and final bibliographic selection (n = 35). Data Collection At first, a systematic review of the literature was performed. Subsequently, from the main selection, randomized and non-randomized trials with metformin that presented their results in absolute and relative numbers of PE outcomes were selected. The variables were treated statistically in the meta-analysis with the Review Manager software (RevMan), version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration. Denmark in the Hovedistaden region. Synthesis of Data The study showed that metmorfin presented greater preventive effects for pregnancy-induced hypertension and was less effective for PE. Conclusion Metformin may gain place in preventive treatments for PE, once the dosages, the gestational age, and treatment time are particularly evaluated. A methodological strategy with an improved perspective of innovative and/or carefully progressive dosages during pregnancy to avoid side effects and the possibility of maternal-fetal risks is suggested.

scholarly journals Systematic Reviews and Meta-Analysis in Spine Surgery—How Good Are They in Methodological Quality? A Systematic Review

2020 ◽  
pp. 219256822090681 ◽  
Author(s):  
Muthu Sathish ◽  
Ramakrishnan Eswar
Keyword(s):  
Systematic Review ◽  
Spine Surgery ◽  
Systematic Reviews ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Eligibility Criteria ◽  
Cochrane Database ◽  
Critical Flaw ◽  
Meta Analyses

Study Design: Systematic review. Objectives: To assess the methodological quality of systematic reviews and meta-analyses in spine surgery over the past 2 decades. Materials and Methods: We conducted independent and in duplicate systematic review of the published systematic reviews and meta-analyses between 2000 and 2019 from PubMed Central and Cochrane Database pertaining to spine surgery involving surgical intervention. We searched bibliographies to identify additional relevant studies. Methodological quality was evaluated with AMSTAR score and graded with AMSTAR 2 criteria. Results: A total of 96 reviews met the eligibility criteria, with mean AMSTAR score of 7.51 (SD = 1.98). Based on AMSTAR 2 criteria, 13.5% (n = 13) and 18.7% (n = 18) of the studies had high and moderate level of confidence of results, respectively, without any critical flaws. A total of 29.1% (n = 28) of the studies had at least 1 critical flaw and 38.5% (n = 37) of the studies had more than 1 critical flaw, so that their results have low and critically low confidence, respectively. Failure to analyze the conflict of interest of authors of primary studies included in review and lack of list of excluded studies with justification were the most common critical flaw. Regression analysis demonstrated that studies with funding and studies published in recent years were significantly associated with higher methodological quality. Conclusion: Despite improvement in methodological quality of systematic reviews and meta-analyses in spine surgery in current decade, a substantial proportion continue to show critical flaws. With increasing number of review articles in spine surgery, stringent measures must be taken to adhere to methodological quality by following PRISMA and AMSTAR guidelines to attain higher standards of evidence in published literature.

scholarly journals Self-concept in poor readers: a systematic review and meta-analysis

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8772 ◽  
Author(s):  
Genevieve M. McArthur ◽  
Nicola Filardi ◽  
Deanna A. Francis ◽  
Mark E. Boyes ◽  
Nicholas A. Badcock
Keyword(s):  
Systematic Review ◽  
Primary Outcome ◽  
Strong Association ◽  
Physical Appearance ◽  
Self Concept ◽  
Poor Reading ◽  
Quality Of Evidence ◽  
Secondary Outcomes ◽  
Meta Analyses

Background The aims of this systematic review and meta-analyses were to determine if there is a statistically reliable association between poor reading and poor self-concept, and if such an association is moderated by domain of self-concept, type of reading impairment, or contextual factors including age, gender, reading instruction, and school environment. Methodology We searched 10 key databases for published and unpublished studies, as well as reference lists of included studies, and studies that cited included studies. We calculated standardised mean differences (SMDs) and 95% confidence intervals for one primary outcome (average self-concept) and 10 secondary outcomes (10 domains of self-concept). We assessed the data for risk of bias, heterogeneity, sensitivity, reporting bias, and quality of evidence. Results Thirteen studies with 3,348 participants met our selection criteria. Meta-analyses revealed statistically significant SMDs for average self-concept (−0.57) and five domains of self-concept (reading/writing/spelling: −1.03; academic: −0.67; math: −0.64; behaviour: −0.32; physical appearance: −0.28). The quality of evidence for the primary outcome was moderate, and for secondary outcomes was low, due to lack of data. Conclusions These outcomes suggest a probable moderate association between poor reading and average self-concept; a possible strong association between poor reading and reading-writing-spelling self-concept; and possible moderate associations between poor reading and self-concept in the self-concept domains of academia, mathematics, behaviour, and physical appearance.

scholarly journals Effectiveness of Exercise on Osteosarcopenia in Elderly People: A Protocol Systematic Review

2020 ◽  
Author(s):  
Guilherme Elias Vinícius-Souza ◽  
Matias Noll ◽  
Erika Aparecida Silveira
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Physical Exercise ◽  
Good Health ◽  
Complementary Therapy ◽  
Assessment Development ◽  
Physical Exercises ◽  
Review Protocol ◽  
Meta Analyses

Abstract Background: Osteosarcopenia is defined as the concomitant occurrence of sarcopenia and osteopenia or osteoporosis. Older adults with this syndrome have greater fragility and chances of mortality compared to those without these conditions. Exercise has been recommended as a treatment for osteosarcopenia based on interventions with sarcopenic and osteoporotic individuals separately. However, there is no evidence that physical exercise can really be an effective treatment for osteosarcopenia. Our objective is to identify whether physical exercise can improve the osteosarcopenia in older adults and lead to good health outcomes. Methods: We will perform a systematic review on the follow databases: PubMed, Embase, Cochrane, and Scopus. The criterion of inclusion will be clinical trial studies in which the interventions were physical exercises in older adults diagnosed with osteosarcopenia. To assess the risk of bias, the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) and the Black and Downs tools will be used. For each search result, the quality of the evidence will ultimately receive one of four grades: high quality, moderate quality, low quality, or very low quality. Discussion: Through this systematic review protocol, an article on physical exercise recommendations for osteosarcopenia in older adults will be prepared. The results of this study may lead to recommendations for physical exercise as a non-pharmacological treatment or complementary therapy for the prevention of osteosarcopenia.Systematic review registration: Ongoing on Prospero.Ethics and dissemination: Protocol written according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA).

A systematic review of meta-analyses in orthopaedic surgery between 2000 and 2016

2018 ◽  
Vol 100-B (10) ◽  
pp. 1270-1274 ◽  
Author(s):  
A. Manta ◽  
E. Opingari ◽  
A. H. Saleh ◽  
N. Simunovic ◽  
A. Duong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Orthopaedic Surgery ◽  
Meta Analysis ◽  
Eligibility Criteria ◽  
Quality Review ◽  
Orthopaedic Literature ◽  
Medium Quality ◽  
The Mean ◽  
Meta Analyses

Aims The aims of this systematic review were to describe the quantity and methodological quality of meta-analyses in orthopaedic surgery published during the last 17 years. Materials and Methods MEDLINE, EMBASE, and PubMed, between 1 January 2000 and 31 December 2016, were searched for meta-analyses in orthopaedic surgery dealing with at least one surgical intervention. Meta-analyses were included if the interventions involved a human muscle, ligament, bone or joint. Results A total of 392 meta-analyses met eligibility criteria, for which the mean AMSTAR quality score was 7.1/11. There was a positive correlation between the year of publication and the quality of the meta-analysis (r = 0.238, p < 0.001). Between 2000 and 2011, the mean AMSTAR score corresponded to that of a medium quality review. However, between 2012 and 2016, the mean scores have been consistently equivalent to those of a high-quality review. The number of meta-analyses published increased 10-fold between 2005 and 2014. Conclusion The quantity and quality of meta-analyses in orthopaedic surgery which have been published has increased, reaching a plateau in 2012. Methodological flaws remain to be addressed in future meta-analyses in order to continue increasing the quality of the orthopaedic literature. Cite this article: Bone Joint J 2018;100-B:1270–4.

scholarly journals A Systematic Review of the Physiological Effects of the Effortful Swallow Maneuver in Adults With Normal and Disordered Swallowing

2020 ◽  
Vol 29 (3) ◽  
pp. 1655-1673
Author(s):  
Mariana M. Bahia ◽  
Soren Y. Lowell
Keyword(s):  
Systematic Review ◽  
Upper Esophageal Sphincter ◽  
Future Research ◽  
Eligibility Criteria ◽  
Swallowing Function ◽  
Effortful Swallow ◽  
Medium Quality ◽  
Esophageal Sphincter ◽  
Meta Analyses

Purpose This systematic review summarizes the biomechanical and functional effects of the effortful swallow in adults with and without dysphagia, highlighting clinical implications and future research needs. Specifically, the effects of the effortful swallow on swallowing physiology, safety, and efficiency were identified, as well as the strengths and limitations of current research. Method Recommendations specified by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses were followed. A literature search of three databases and relevant articles cited in the searched studies was performed. Two evaluators independently analyzed the studies for eligibility criteria, and final inclusion of studies was decided by consensus. Evaluators also assessed each study for quality of evidence. Results Twenty-three studies were included in this systematic review. Main findings indicated that the effortful swallow generated greater pressures in the tongue-to-palate, pharynx, upper esophageal sphincter, and esophageal regions. Inconsistent results for hyolaryngeal excursion were reported, as well as for swallowing function. Instructions of the effortful swallow varied greatly across studies. Two of the 23 studies were judged to be of high quality, and the remaining studies were of medium quality based on the quality indicators of this review. Conclusions Biomechanical effects of the effortful swallow included increased pressures in the oral, pharyngeal, and esophageal regions. Future investigations should address the effects of the effortful swallow in individuals with dysphagia and its potential role as a rehabilitative maneuver. Moreover, standardization of the effortful swallow instructions based on its physiological and functional effects is essential.

scholarly journals Exercise as a Therapeutic and Supporting Strategy for Climacteric Symptoms: an Evidence-Based Review

2021 ◽  
Vol 23 (1) ◽  
pp. 35-38
Author(s):  
Rodrigo Gomes Pereira Pinto ◽  
David Michel de Oliveira ◽  
Anderson Geremias Macedo ◽  
Giselle Soares Passos
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Physical Exercise ◽  
Scientific Evidence ◽  
Experimental Studies ◽  
Health Improvement ◽  
Climacteric Symptoms ◽  
Eligibility Criteria ◽  
Cross Sectional

AbstractClimacteric is a natural process characterized by the female hormones reduction and increased symptoms that interfere in the woman's quality of life. The objective was to raise scientific evidence on the physical exercise effects as a therapeutic strategy on climacteric symptoms. This systematic review study accessed the Virtual Health Library (VHL) and consulted articles from the last 10 years, with the following eligibility criteria; inclusion, scientific articles published in the last 10 years, with clinical, quasi-experimental, cross-sectional design and case studies conducted with women in the climacteric. Articles published before 2010 with delineations were excluded; epidemiological, systematic review, meta-analyzes, experimental studies with animal model. The studies included in the review were read in full, critically analyzed and categorized. The findings showed that active women have a reduction in vasomotor and somatic symptoms of the climacteric, also collaborating in the prevention of diseases prevalent in this period. Aerobic physical exercise improves physical fitness and quality of life indicators of climacteric women. In clinical practice, aerobic exercise can be considered an auxiliary strategy in the climacteric symptoms treatment and female health improvement. Keywords: Climacteric. Health. Physical Exercise. ResumoO climatério é um processo natural caracterizado pela redução dos hormônios femininos e aumento de sintomas que interferem na qualidade de vida da mulher. Objetivou-se levantar evidências científicas sobre os efeitos do exercício físico como estratégia terapêutica na sintomatologia climatérica. Este estudo de revisão sistemática acessou a Biblioteca Virtual de Saúde (BVS) e consultou artigo dos últimos 10 anos, com os seguintes critérios de elegibilidade; inclusão, artigos científicos com delineamento clínico, quase-experimental, transversal e estudos de caso realizados com mulheres no climatério. Foram excluídos artigos publicados anterior a 2010, com delineamentos; epidemiológico, revisão sistemática, metanálises, estudos experimentais com modelo animal. Os estudos incluídos na revisão foram lidos na integra, analisados criticamente e categorizados. Os achados demonstraram que mulheres ativas apresentam redução dos sintomas vasomotores e somáticos do climatério, também colabora na prevenção de doenças prevalentes nesse período. O exercício físico aeróbio melhora a aptidão física e indicadores de qualidade de vida de mulheres climatéricas. Na prática clínica o exercício aeróbio pode ser considerado uma estratégia auxiliar no tratamento dos sintomas do climatério e melhora da saúde feminina. Palavras-chave: Climatério. Saúde. Exercício Físico.

scholarly journals Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis

2017 ◽  
Vol 52 (3) ◽  
pp. 154-160 ◽  
Author(s):  
Joseph Michael Northey ◽  
Nicolas Cherbuin ◽  
Kate Louise Pumpa ◽  
Disa Jane Smee ◽  
Ben Rattray
Keyword(s):  
Systematic Review ◽  
Cognitive Function ◽  
Physical Exercise ◽  
Meta Analysis ◽  
Cognitive Status ◽  
Community Dwelling ◽  
Cognitive Domain ◽  
Moderate Intensity ◽  
Eligibility Criteria ◽  
Exercise Interventions

BackgroundPhysical exercise is seen as a promising intervention to prevent or delay cognitive decline in individuals aged 50 years and older, yet the evidence from reviews is not conclusive.ObjectivesTo determine if physical exercise is effective in improving cognitive function in this population.DesignSystematic review with multilevel meta-analysis.Data sourcesElectronic databases Medline (PubMed), EMBASE (Scopus), PsychINFO and CENTRAL (Cochrane) from inception to November 2016.Eligibility criteriaRandomised controlled trials of physical exercise interventions in community-dwelling adults older than 50 years, with an outcome measure of cognitive function.ResultsThe search returned 12 820 records, of which 39 studies were included in the systematic review. Analysis of 333 dependent effect sizes from 36 studies showed that physical exercise improved cognitive function (0.29; 95% CI 0.17 to 0.41; p<0.01). Interventions of aerobic exercise, resistance training, multicomponent training and tai chi, all had significant point estimates. When exercise prescription was examined, a duration of 45–60 min per session and at least moderate intensity, were associated with benefits to cognition. The results of the meta-analysis were consistent and independent of the cognitive domain tested or the cognitive status of the participants.ConclusionsPhysical exercise improved cognitive function in the over 50s, regardless of the cognitive status of participants. To improve cognitive function, this meta-analysis provides clinicians with evidence to recommend that patients obtain both aerobic and resistance exercise of at least moderate intensity on as many days of the week as feasible, in line with current exercise guidelines.

scholarly journals Quality of life among cancer inpatients 80 years and older: a systematic review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jorunn Drageset ◽  
Reidun Karin Sandvik ◽  
Leslie Sofia Pareja Eide ◽  
Gunhild Austrheim ◽  
Mary Fox ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Cancer Patients ◽  
Patient Group ◽  
Malignant Tumors ◽  
Symptom Burden ◽  
Eligibility Criteria ◽  
Critical Appraisal Skills ◽  
Meta Analyses

Abstract Objective The aim of this systematic review was to summarize and assess the literature on quality of life (QoL) among cancer patients 80 years and older admitted to hospitals and what QoL instruments have been used. Methods We searched systematically in Medline, Embase and Cinahl. Eligibility criteria included studies with any design measuring QoL among cancer patients 80 years and older hospitalized for treatment (surgery, chemotherapy or radiation therapy). Exclusion criteria: studies not available in English, French, German or Spanish. We screened the titles and abstracts according to a predefined set of inclusion criteria. All the included studies were assessed according to the Critical Appraisal Skills Programme checklists, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement checklist was used to ensure rigor in conducting and reporting. This systematic review was registered in PROSPERO (CRD42017058290). Results We included 17 studies with 2005 participants with various cancer diagnoses and Classification of Malignant Tumors stages (TNM). The included studies used a range of different QoL instruments and had different aims and outcomes. Both cancer-specific and generic instruments were used. Only one of the 17 studies used an age-specific instrument. All the studies included patients 80 years and older in their cohort, but none specifically analyzed QoL outcomes in this particular subgroup. Based on findings in the age-heterogeneous population (age range 20–100 years), QoL seems to be correlated with the type of diagnosed carcinoma, length of stay, depression and severe symptom burden. Conclusion We were unable to find any research directly exploring QoL and its determinants among cancer patients 80 years and older since none of the included studies presented specific analysis of data in this particular age subgroup. This finding represents a major gap in the knowledge base in this patient group. Based on this finding, we strongly recommend future studies that include this increasingly important and challenging patient group to use valid age- and diagnosis-specific QoL instruments.

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