scholarly journals Left angular gyrus disconnection impairs multiplication fact retrieval

2021 ◽  
Author(s):  
Stefan Smaczny ◽  
Christoph Sperber ◽  
Stefanie Jung ◽  
Korbinian Moeller ◽  
Hans-Otto Karnath ◽  
...  
Keyword(s):  
White Matter ◽  
Superior Temporal Gyrus ◽  
Angular Gyrus ◽  
Subcortical Structures ◽  
Arithmetic Fact ◽  
White Matter Tractography ◽  
White Matter Connectivity ◽  
Left Angular Gyrus ◽  
Fact Retrieval ◽  
Arithmetic Fact Retrieval

Arithmetic fact retrieval has been suggested to recruit a left-lateralized network comprising perisylvian language areas, parietal areas such as the angular gyrus (AG), and subcortical structures such as the hippocampus. However, the underlying white matter connectivity of these areas has not been evaluated systematically so far. Using simple multiplication problems, we evaluated how disconnections in parietal brain areas affected arithmetic fact retrieval following stroke. We derived disconnectivity measures by jointly considering data from n=73 patients with acute unilateral lesions in either hemisphere and a white-matter tractography atlas (HCP-842) using the Lesion Quantification Toolbox (LQT). Whole-brain voxel-based analysis indicated a left-hemispheric cluster of white matter fibers connecting the AG and superior temporal areas to be associated with a fact retrieval deficit. Subsequent analyses of direct grey-to-grey matter disconnections revealed that disconnections of additional left-hemispheric areas (e.g., between the superior temporal gyrus and parietal areas) were significantly associated with the observed fact retrieval deficit. Results imply that disconnections of parietal areas (i.e., the AG) with language-related areas (i.e., superior and middle temporal gyri) seem specifically detrimental to arithmetic fact retrieval. This suggests that arithmetic fact retrieval recruits a widespread left-hemispheric network and emphasizes the relevance of white matter connectivity for number processing.

scholarly journals The convergence and divergence of episodic and semantic functions across lateral parietal cortex

2020 ◽  
Author(s):  
Gina F. Humphreys ◽  
JeYoung Jung ◽  
Matthew A. Lambon Ralph
Keyword(s):  
White Matter ◽  
Semantic Memory ◽  
Parietal Cortex ◽  
Memory Retrieval ◽  
Task Difficulty ◽  
Structural Connectivity ◽  
Angular Gyrus ◽  
Episodic Retrieval ◽  
Semantic Retrieval ◽  
White Matter Connectivity

AbstractSeveral decades of neuropsychological and neuroimaging research have highlighted the importance of lateral parietal cortex (LPC) across a myriad of cognitive domains. Yet, despite the prominence of this region the underlying function of LPC remains unclear. Two domains that have placed particular emphasis on LPC involvement are semantic memory and episodic memory retrieval. From each domain, sophisticated models have been proposed as to the underlying function, as well as the more domain-general that LPC is engaged by any form of internally-directed cognition (episodic and semantic retrieval both being examples if this process). Here we directly address these alternatives using a combination of fMRI and DTI white-matter connectivity data. The results show that ventral LPC (angular gyrus) was positively engaged during episodic retrieval but disengaged during semantic memory retrieval. In addition, the level of activity negatively varied with task difficulty in the semantic task whereas episodic activation was independent of difficulty. In contrast, dorsal LPC (intraparietal sulcus) showed domain general activation that was positively correlated with task difficulty. In terms of structural connectivity, a dorsal-ventral and anterior-posterior gradient of connectivity was found to different processing networks (e.g., mid-angular gyrus (AG) connected with episodic retrieval). We propose a unifying model in which LPC as a whole might share a common underlying function (e.g., multimodal buffering) and variations across subregions arise due to differences in the underlying white matter connectivity.

scholarly journals Pathways to arithmetic fact retrieval and percentage calculation in adolescents

2017 ◽  
Vol 87 (4) ◽  
pp. 647-663 ◽  
Author(s):  
Ulf Träff ◽  
Kenny Skagerlund ◽  
Linda Olsson ◽  
Rickard Östergren
Keyword(s):  
Arithmetic Fact ◽  
Fact Retrieval ◽  
Arithmetic Fact Retrieval

Number Processing and Arithmetic in Children and Adults with Reading Difficulties

2014 ◽  
Author(s):  
Silke M. Göbel
Keyword(s):  
Reading Difficulties ◽  
Basic Number ◽  
Number Processing ◽  
Angular Gyrus ◽  
Long Term Memory ◽  
Co Morbidity ◽  
And Mathematics ◽  
A Site ◽  
Left Angular Gyrus ◽  
Fact Retrieval

Basic number processing skills in individuals with reading difficulties (RD) are intact. However, children and adults with RD show clear difficulties in arithmetic, in particular in retrieving known answers from long-term memory (fact retrieval). Fact retrieval deficits are associated with weaknesses in phonological awareness, the ability to segment and manipulate speech sounds. The left angular gyrus has been suggested as a site of neurological overlap between RD and fact retrieval deficits. While there is evidence for an involvement of the angular gyrus in fact retrieval in adults, the evidence for children is less clear. The same genetic risk factors may underlie difficulties in reading and mathematics and cause the high co-morbidity between RD and mathematical difficulties. Implications for interventions are discussed.

scholarly journals Frontal and parietal contributions to arithmetic fact retrieval: A parametric analysis of the problem-size effect

2010 ◽  
Vol 32 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Kerstin Jost ◽  
Patrick H. Khader ◽  
Michael Burke ◽  
Siegfried Bien ◽  
Frank Rösler
Keyword(s):  
Size Effect ◽  
Parametric Analysis ◽  
Problem Size ◽  
Arithmetic Fact ◽  
Problem Size Effect ◽  
Fact Retrieval ◽  
Arithmetic Fact Retrieval

Modulating arithmetic fact retrieval: A single-blind, sham-controlled tDCS study with repeated fMRI measurements

2013 ◽  
Vol 51 (7) ◽  
pp. 1279-1286 ◽  
Author(s):  
Benjamin Clemens ◽  
Stefanie Jung ◽  
Mikhail Zvyagintsev ◽  
Frank Domahs ◽  
Klaus Willmes
Keyword(s):  
Arithmetic Fact ◽  
Fact Retrieval ◽  
Single Blind ◽  
Arithmetic Fact Retrieval

Current sources of the event-related potentials (ERP) during arithmetic fact retrieval: Differences among children and adults

2010 ◽  
Vol 77 (3) ◽  
pp. 299-299
Author(s):  
B. Prieto-Corona ◽  
M. Rodríguez-Camacho ◽  
J. Silva-Pereyra ◽  
E. Marosi ◽  
J. Bernal ◽  
...  
Keyword(s):  
Event Related Potentials ◽  
Arithmetic Fact ◽  
Related Potentials ◽  
Fact Retrieval ◽  
Arithmetic Fact Retrieval
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