scholarly journals Drosulfakinin signaling modulates female sexual receptivity in Drosophila

2021 ◽  
Author(s):  
Chuan Zhou ◽  
Tao Wang ◽  
Biyang Jing ◽  
Bowen Deng ◽  
Kai Shi ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Neuronal Activity ◽  
Input Signal ◽  
Sexual Receptivity ◽  
Innate Behavior ◽  
Female Sexual Behavior ◽  
Downstream Signaling ◽  
Biological Importance ◽  
Survival And Reproduction ◽  
Female Sexual Receptivity

Female sexual behavior as an innate behavior is of prominent biological importance for survival and reproduction. However, molecular and circuit mechanisms underlying female sexual behavior is not well understood. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) promotes female sexual behavior in Drosophila. Manipulation both Dsk and DSK neuronal activity impact female sexual receptivity. In addition, we reveal that Dsk-expressing neurons receive input signal from R71G01GAL4 neurons to promote female sexual receptivity. Based on intersectional technique, we further found the regulation of female sexual behavior relies mainly on medial DSK neurons rather than lateral DSK neurons, and medial DSK neurons modulate female sexual behavior by acting on its receptor CCKLR-17D3. Thus, we characterized DSK/CCKLR-17D3 as R71G01GAL4 neurons downstream signaling to regulate female sexual behavior.

Disinhibition of female sexual behavior by a CRH receptor antagonist in Syrian hamsters

2002 ◽  
Vol 283 (3) ◽  
pp. R591-R597 ◽  
Author(s):  
Juli E. Jones ◽  
Rebecca R. Pick ◽  
Matthew D. Davenport ◽  
Alex C. Keene ◽  
Eric S. Corp ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Receptor Antagonist ◽  
Direct Evidence ◽  
Sexual Receptivity ◽  
Receptor Signaling ◽  
Common Pathway ◽  
Female Sexual Behavior ◽  
Central Actions ◽  
The Brain ◽  
Estrous Behavior

Several conditions that inhibit female sexual behavior are thought to be associated with altered corticotropin-releasing hormone (CRH) activity in the brain. The present experiments examined the hypothesis that endogenous CRH receptor signaling mediates the inhibition of estrous behavior by undernutrition and in other instances of sexual dysfunction. Intracerebroventricular (ICV) infusion of CRH or urocortin inhibited estrous behavior in ovariectomized steroid-primed hamsters. Conversely, ICV infusion of the CRH receptor antagonist astressin prevented the suppression of estrous behavior by food deprivation or by ICV administration of neuropeptide Y. Astressin treatment also induced sexual receptivity in nonresponders, animals that do not normally come into heat when treated with hormones, and this effect persisted in subsequent weekly tests in the absence of any further astressin treatment. Activation of the hypothalamo-pituitary-adrenocortical axis was neither necessary nor sufficient to inhibit estrous behavior, indicating that this phenomenon is due to other central actions of CRH receptor agonists. This is the first direct evidence that CRH receptor signaling may be a final common pathway by which undernutrition and other conditions inhibit female sexual behavior.

Maternal treatment with picrotoxin in late pregnancy improved female sexual behavior but did not alter male sexual behavior of offspring

2013 ◽  
Vol 24 (4) ◽  
pp. 282-290 ◽  
Author(s):  
Maria M. Bernardi ◽  
Kayne K. Scanzerla ◽  
Mayra Chamlian ◽  
Elizabeth Teodorov ◽  
Luciano F. Felicio
Keyword(s):  
Sexual Behavior ◽  
Late Pregnancy ◽  
Female Sexual Behavior ◽  
Male Sexual Behavior ◽  
Maternal Treatment

Sex hormone binding globulin stimulates female sexual receptivity

2000 ◽  
Vol 874 (1) ◽  
pp. 24-29 ◽  
Author(s):  
J.D. Caldwell ◽  
B.D. Moe ◽  
J. Hoang ◽  
T. Nguyen
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sexual Receptivity ◽  
Hormone Binding ◽  
Female Sexual Receptivity

Female Sexual Behavior in Rodents, Lagomorphs, and Goats

2017 ◽  
pp. 59-82 ◽  
Author(s):  
Oscar González-Flores ◽  
Kurt L. Hoffman ◽  
José A. Delgadillo ◽  
Matthieu Keller ◽  
Raúl G. Paredes
Keyword(s):  
Sexual Behavior ◽  
Female Sexual Behavior
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